Cited by 245Birth, Development, and HealthEpigenetics and DNA MethylationMaternal Mental Health During Pregnancy and Postpartum

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Maternal psychosocial stress during pregnancy alters the epigenetic signature of the glucocorticoid receptor gene promoter in their offspring: a meta-analysis

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Palma-Gudiel, H, Córdova-Palomera, A, Eixarch, E, Deuschle, M, Fañanás, L·2015·Epigenetics

DOI 10.1080/15592294.2015.1088630PMC PMC4844196

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Abstract

Prenatal stress has been widely associated with a number of short- and long-term pathological outcomes. Epigenetic mechanisms are thought to partially mediate these environmental insults into the fetal physiology. One of the main targets of developmental programming is the hypothalamic-pituitary-adrenal (HPA) axis as it is the main regulator of the stress response. Accordingly, an increasing number of researchers have recently focused on the putative association between DNA methylation at the glucocorticoid receptor gene (NR3C1) and prenatal stress, among other types of psychosocial stress. The current study aims to systematically review and meta-analyze the existing evidence linking several forms of prenatal stress with DNA methylation at the region 1F of the NR3C1 gene. The inclusion of relevant articles allowed combining empirical evidence from 977 individuals by meta-analytic techniques, whose methylation assessments showed overlap across 5 consecutive CpG sites (GRCh37/hg19 chr5:142,783,607-142,783,639). From this information, methylation levels at CpG site 36 displayed a significant correlation to prenatal stress (r = 0.14, 95% CI: 0.05-0.23, P = 0.002). This result supports the proposed association between a specific CpG site located at the NR3C1 promoter and prenatal stress. Several confounders, such as gender, methylation at other glucocorticoid-related genes, and adjustment for pharmacological treatments during pregnancy, should be taken into account in further studies.

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Authors: Palma-Gudiel, H., Córdova-Palomera, A., Eixarch, E., Deuschle, M., & Fañanás, L.
Affiliations: Hospital Sant Joan de Déu Barcelona (ES)
University of Mannheim (DE)
Centro de Investigación Biomédica en Red de Salud Mental (ES)
Corresponding author: Fañanás, L
ORCID: Eixarch, E
Deuschle, M
Fañanás, L
Venue: Epigenetics
Publisher: Informa UK Limited
Published: 2015-09
Volume: 10
Issue: 10
Pages: 893-902
ISSN: 1559-2294 (ISSN-L)
1559-2308
DOI: 10.1080/15592294.2015.1088630
PMC: PMC4844196
OpenAlex: W1851806939
Cited by: 240
References: 65
Citations by year: 2026: 15 · 2025: 19 · 2024: 22 · 2023: 29 · 2022: 18 · 2021: 21 · 2020: 25 · 2019: 22 · 2018: 30 · 2017: 27 · 2016: 12
FWCI: 3.49
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Epigenetics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Universitat Pompeu Fabra
University of Reading
Generalitat de Catalunya (2014SGR1636)
Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya
Ministerio de Ciencia e Innovación (PIM2010ERN-00642, SAF2008-05674-C03-01)
Centro de Investigación Biomédica en Red de Salud Mental
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords: prenatal stress, maternal psychosocial stress, glucocorticoid receptor, NR3C1, DNA methylation, promoter methylation, CpG sites, developmental programming, hypothalamic-pituitary-adrenal axis, pregnancy
MeSH terms: Female, Humans, Male, Pituitary-Adrenal System, Pregnancy, Prenatal Exposure Delayed Effects, Promoter Regions, Genetic, Receptors, Glucocorticoid, Stress, Psychological, CpG Islands, DNA Methylation, Epigenesis, Genetic

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Maternal psychosocial stress during pregnancy alters the epigenetic signature of the glucocorticoid receptor gene promoter in their offspring: a meta-analysis

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