The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
SLN and NLC for topical, dermal, and transdermal drug delivery
Abstract
Introduction From a biopharmaceutical standpoint, the skin is recognized as an interesting route for drug delivery. In general, small molecules are able to penetrate the stratum corneum, the outermost layer of the skin. In contrast, the delivery of larger molecules, such as peptides and proteins, remains a challenge. Nanoparticles have been exploited not only to enhance skin penetration of drugs but also to expand the range of molecules to be clinically used.Areas covered This review focus on Solid lipid nanoparticles (SLN) and Nanostructured lipid carriers (NLC) for skin administration. We discuss the selection criteria for lipids, surfactants, and surface modifiers commonly in use in SLN/NLC, their production techniques, and the range of drugs loaded in these lipid nanoparticles for the treatment of skin disorders.Expert opinion Depending on the lipid and surfactant composition, different nanoparticle morphologies can be generated. Both SLN and NLC are composed of lipids that resemble those of the skin and sebum, which contribute to their enhanced biocompatibility, with limited toxicological risk. SLN and NLC can be loaded with very chemically different drugs, may provide a tunable release profile, can be produced in a sterilized environment, and be scaled-up without the need for organic solvents.
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Cites
Solid lipid nanoparticles Production, characterization and applications
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Solid lipid nanoparticles for parenteral drug delivery
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Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products
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Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application
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Solid lipid nanoparticles as a drug delivery system for peptides and proteins☆
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Self-citationNanostructured lipid carriers: Promising drug delivery systems for future clinics
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Nanostructured lipid carriers for site-specific drug delivery
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Lipid nanoparticles for improved topical application of drugs for skin diseases☆
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Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
Liu, Y., Liang, Y., Yuhong, J., Xin, P., Han, J. L., Du, Y., Yu, X., Zhu, R., Zhang, M., Chen, W., et al. (2024) · Drug Design, Development and Therapy · doi:10.2147/dddt.s447496 · Cited by 365
Kim, M., Shin, M., Zhao, Y., Ghosh, M., & Son, Y. (2024) · Small Science · doi:10.1002/smsc.202400280 · Cited by 97
Nanocarrier system: An emerging strategy for bioactive peptide delivery
Zhang, X., Li, X., Zhao, Y., Zheng, Q., Wu, Q., & Yu, Y. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1050647 · Cited by 63
Metadata
- Authors
- Souto, E. B., Baldim, I., Oliveira, W. P., Rao, R., Yadav, N., Gama, F. M., & Mahant, S.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2020-02-17
- Volume
- 17
- Issue
- 3
- Pages
- 357-377
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W3006719128
- Cited by
- 328
- References
- 157
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Souto, E. B., Baldim, I., Oliveira, W. P., Rao, R., Yadav, N., Gama, F. M., & Mahant, S. (2020). SLN and NLC for topical, dermal, and transdermal drug delivery. Expert Opinion on Drug Delivery. https://doi.org/10.1080/17425247.2020.1727883
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