Impact of probiotic supplements on microbiome diversity following antibiotic treatment of mice
Open accessAbstract
Shifts in microbial populations of the intestinal tract have been associated with a multitude of nutritional, autoimmune, and infectious diseases. The limited diversity following antibiotic treatments creates a window for opportunistic pathogens, diarrhea, and inflammation as the microbiome repopulates. Depending on the antibiotics used, microbial diversity can take weeks to months to recover. To alleviate this loss of diversity in the intestinal microbiota, supplementation with probiotics has become increasingly popular. However, our understanding of the purported health benefits of these probiotic bacteria and their ability to shape the microbiome is significantly lacking. This study examined the impact of probiotics concurrent with antibiotic treatment or during the recovery phase following antibiotic treatment of mice. We found that probiotics did not appear to colonize the intestine themselves or shift the overall diversity of the intestinal microbiota. However, the probiotic supplementation did significantly change the types of bacteria which were present. In particular, during the recovery phase the probiotic caused a suppression of Enterobacteriaceae outgrowth (Shigella and Escherichia) while promoting a blooming of Firmicutes, particularly from the Anaerotruncus genus. These results indicate that probiotics have a significant capacity to remodel the microbiome of an individual recovering from antibiotic therapy.
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Probiotics-treated hosts after antibiotics have a lower number of observed species in gut microbiota.
“This study and others also demonstrated a lower number of observed species in the gut microbiota of probiotics-treated hosts after antibiotics.93–95”
From Emerging issues in probiotic safety: 2023 perspectives (2023) · cites this paper as [94]
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- Authors
- Grazul, H., Kanda, L. L., & Gondek, D.
- Affiliations
- Ithaca College (US)
- Corresponding author
- Gondek, David
- ORCID
- Gondek, David
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2016-03-03
- Volume
- 7
- Issue
- 2
- Pages
- 101-114
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC4856465
- OpenAlex
- W2302109531
- Cited by
- 135
- References
- 59
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 10 · 2023: 19 · 2022: 17 · 2021: 17 · 2020: 20 · 2019: 8 · 2018: 15 · 2016: 2
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Collections - Ithaca College Library (Ithaca College) (submittedVersion, public-domain)
- Digital Collections - Ithaca College Library (Ithaca College) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- probiotics, gut microbiota, microbiome diversity, antibiotic therapy, antibiotic-associated diarrhea, microbiome recovery, Enterobacteriaceae, Escherichia, Shigella, Firmicutes, Anaerotruncus, probiotic colonization, mice
- MeSH terms
- Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Bacteria, Diarrhea, Female, Humans, Male, Mice, Inbred C57BL, Dietary Supplements, Probiotics, Gastrointestinal Tract, Biodiversity, Mice
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