Cited by 67Probiotics and Fermented FoodsGut microbiota and healthReproductive tract infections research

Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity

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Lee, Amanda H., Rodriguez Jimenez, Daphne Michelle, Meisel, Marlies·2025·Gut Microbes

Abstract

The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. The historical roots of probiotics are traced back to Nobel Laureate Élie Metchnikoff, who linked the longevity of Bulgarian villagers to their consumption of sour milk fermented by Lactobacilli. His pioneering work led to the global recognition of probiotics as beneficial supplements, now a multibillion-dollar industry. Modern probiotics have been extensively studied for their immunomodulatory effects. Limosilactobacillus reuteri (L. reuteri), a widely used probiotic, has garnered significant attention for its systemic immune-regulatory properties, particularly in relation to autoimmunity and cancer. This review delves into the role of L. reuteri in modulating immune responses, with a focus on its impact on systemic diseases.

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Authors
Lee, A. H., Rodriguez Jimenez, D. M., & Meisel, M.
Affiliations
  • University of Pittsburgh (US)
  • University of Pittsburgh School of Medicine
Corresponding author
Meisel, Marlies
Venue
Gut Microbes
Published
2025-01-17
Volume
17
Issue
1
Pages
2451088-2451088
ISSN
  • 1949-0976 (ISSN-L)
  • 1949-0984
OpenAlex
W4406581210
Cited by
66
References
125
Citations by year
2026: 40 · 2025: 26
FWCI
5.38
Type
journal article
Language
en
Open access
Locations
  • Gut Microbes (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • University of Pittsburgh
  • Melanoma Research Alliance
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
Lactobacillus reuteri, probiotics, gut microbiota, immunomodulation, autoimmunity, cancer, gut commensals, sour milk, Metchnikoff
MeSH terms
Gastrointestinal Microbiome, Animals, Humans, Neoplasms, Probiotics, Limosilactobacillus reuteri

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