Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity
Open accessAbstract
The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. The historical roots of probiotics are traced back to Nobel Laureate Élie Metchnikoff, who linked the longevity of Bulgarian villagers to their consumption of sour milk fermented by Lactobacilli. His pioneering work led to the global recognition of probiotics as beneficial supplements, now a multibillion-dollar industry. Modern probiotics have been extensively studied for their immunomodulatory effects. Limosilactobacillus reuteri (L. reuteri), a widely used probiotic, has garnered significant attention for its systemic immune-regulatory properties, particularly in relation to autoimmunity and cancer. This review delves into the role of L. reuteri in modulating immune responses, with a focus on its impact on systemic diseases.
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Prior work showed that the microbial AhR agonist indole-3-aldehyde enhances Tc1 immunity, aggravates autoimmunity, and improves ICI efficacy.
“Prior work demonstrated that the microbial AhR agonist indole-3-aldehyde enhances Tc1 immunity, aggravating autoimmunity46 and improving ICI efficacy32,47.”
From Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy (2025) · cites this paper as [47]
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Ellena, G., Mazzoli, A., Gupta, S., Spacova, I., Leys, N., Lebeer, S., & Mastroleo, F. (2026) · iScience · doi:10.1016/j.isci.2026.117979
The potential impact of probiotics on human health
Mishra, S., Dagariya, S., Tiwari, S., & Dakal, T. C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45154-6.00034-9
- Authors
- Lee, A. H., Rodriguez Jimenez, D. M., & Meisel, M.
- Affiliations
- University of Pittsburgh (US)
- University of Pittsburgh School of Medicine
- Corresponding author
- Meisel, Marlies
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2025-01-17
- Volume
- 17
- Issue
- 1
- Pages
- 2451088-2451088
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- OpenAlex
- W4406581210
- Cited by
- 66
- References
- 125
- Citations by year
- 2026: 40 · 2025: 26
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Gut Microbes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Pittsburgh
- Melanoma Research Alliance
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- Lactobacillus reuteri, probiotics, gut microbiota, immunomodulation, autoimmunity, cancer, gut commensals, sour milk, Metchnikoff
- MeSH terms
- Gastrointestinal Microbiome, Animals, Humans, Neoplasms, Probiotics, Limosilactobacillus reuteri
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