The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The seven faces of SIRT7
Open accessAbstract
-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress resistance, aging and tumorigenesis. Despite this important functional link, the enzymatic activity, the molecular targets and physiological functions of SIRT7 are poorly defined. Here, we review recent progress in SIRT7 research and elaborate the main pathways in which SIRT7 participates.
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“In contrast to the broadly repressive actions often attributed to other sirtuins, SIRT7 appears necessary for preserving active rDNA transcription under conditions of cellular growth and stress [183,184].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [184]
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“Given its dependence on intracellular NAD+ availability, SIRT7 may provide a mechanistic link between cellular energetic status and nucleolar function [184].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [184]
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Citations
Cites
1 retracted
Zhang, S., Chen, P., Huang, Z., Hu, X., Chen, M., Hu, S., Hu, Y. J., & Cai, T. (2015) · Scientific Reports · doi:10.1038/srep09787 · Cited by 111
RetractedMitochondria: In Sickness and in Health
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Michishita, E., Park, J. Y., Burneskis, J. M., Barrett, J. C., & Horikawa, I. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0033 · Cited by 1,364
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Boulon, S., Westman, B. J., Hutten, S., Boisvert, F.-M., & Lamond, A. I. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.024 · Cited by 1,103
Vakhrusheva, O., Smolka, C., Gajawada, P., Sawa Kostin, D., Boettger, T., Kubin, T., Braun, T. W., & Bober, E. (2008) · Circulation Research · doi:10.1161/circresaha.107.164558 · Cited by 646
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
Barber, M. F., Michishita-Kioi, E., Xi, Y., Tasselli, L., Kioi, M., Moqtaderi, Z., Tennen, R. I., Paredes, S., Young, N. L., Chen, K., et al. (2012) · Nature · doi:10.1038/nature11043 · Cited by 635
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
Ford, E., Voit, R., Liszt, G., Magin, C., Grummt, I., & Guarente, L. (2006) · Genes & Development · doi:10.1101/gad.1399706 · Cited by 629
Self-citationGlobal Levels of Histone Modifications Predict Prognosis in Different Cancers
Seligson, D. B., Horvath, S., McBrian, M. A., Mah, V. H., Yu, H., Tze, S., Wang, Q., Chia, D., Goodglick, L., & Kurdistani, S. K. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080874 · Cited by 524
Watkins, N. J., & Bohnsack, M. T. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.117 · Cited by 520
Research works printed but not linked: 1
- 10.1074/mcp.A111.01515 · DOI
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Sorted by citations
Items 101–111 of 111
Muñoz López, M., López-Gil, J. F., Ramírez de la piscina Viúdez, X., Baz-Valle, E., & Tornero Aguilera, J. F. (2026) · Cells · doi:10.3390/cells15111041 · Cited by 1
“In contrast to the broadly repressive actions often attributed to other sirtuins, SIRT7 appears necessary for preserving active rDNA transcription under conditions of cellular growth and stress [183,184].”
Ma, Q., Chen, S., Ma, Z., Li, D.-F., Dang, X., Xu, J.-S., & Zhou, Z. (2024) · Discover Life · doi:10.1007/s11084-024-09660-7 · Cited by 2
Cao, Y., Ma, J., Wang, S., Yang, X., Long, M., Ji, Y., Yu, Z., You, R., Lin, C., Yang, Y., et al. (2025) · Urologia Internationalis · doi:10.1159/000544698 · Cited by 1
Kiran, S., Kiran, M., & Ramakrishna, G. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00740
Kim, Y., Jung, K., Kim, Y. H., Xu, P., Jo, Y., Kang, B. E., Pandit, N., Kwon, J., Gariani, K., Gariani, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.13.531998
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated SIRT7Preprint
Bolding, J. E., Nielsen, A. L., Jensen, I., Hansen, T. N., Ryberg, L. A., Jameson, S. T., Harris, P., Peters, G. H. J., Denu, J. M., Rogers, J. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.16.545261
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7**
Bolding, J. E., Nielsen, A. L., Jensen, I., Hansen, T. N., Ryberg, L. A., Jameson, S. T., Harris, P., Peters, G. H. J., Denu, J. M., Rogers, J. M., et al. (2023) · Angewandte Chemie · doi:10.1002/ange.202314597 · Cited by 1
Jonkhout, M. C. M., Vanhessche, T., Ferreira, M., Verbinnen, I., Withof, F., der Hoeven, G. V., Szekér, K., Azhir, Z., Lien, W., Eynde, A. V., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.02.009
Zhou, Y., Sun, G., Gao, Y., Shan, N., & Qi, H. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112825
Saha, A., De, S., Chattopadhyay, S., Dasgupta, S., & Mitra, A. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12579-z
Chen, W., Yang, D., Liu, H., Tong, S., Liang, G., Zhang, J., Yang, J., & Li, Z. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118519
Metadata
- Authors
- Blank, M. F., & Grummt, I.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Grummt, Ingrid
- Venue
- Transcription
- Publisher
- Informa UK Limited
- Published
- 2017-01-23
- Volume
- 8
- Issue
- 2
- Pages
- 67-74
- ISSN
- 2154-1264 (ISSN-L)
- 2154-1272
- PMC
- PMC5423475
- OpenAlex
- W2571520146
- Cited by
- 111
- References
- 44
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 21 · 2021: 12 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 5
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Transcription (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- SIRT7, ribosome biogenesis, cell cycle checkpoints, metabolic homeostasis, stress tolerance, aging, carcinogenesis, cell proliferation, molecular targets
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Energy Metabolism, Humans, Ribosomes, DNA-Directed RNA Polymerases, Stress, Physiological, Transcription, Genetic, Sirtuins, Genomic Instability, Cell Cycle Checkpoints
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