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Role of gut microbiota in intestinal wound healing and barrier function
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The mammalian intestine harbors a highly complex and abundant ensemble of bacteria that flourish in a nutrient-rich environment while profoundly influencing many aspects of host biology. The intestine coevolved with its resident microbes in a manner where the mucosa developed a barrier function to segregate the resident microbes from the rest of the body, and yet paradoxically, allowing integration of microbial signals for the host benefit. In this review, we provided a comprehensive overview of why the gut microbiota is key to the efficient development and maintenance of the intestinal barrier. We also highlighted how a destabilized equilibrium between gut microbiota and the host may eventuate in a wide range of intestinal diseases characterized by the disrupted intestinal barrier. Finally, the review delineated how microenvironmental changes in the injured mucosa result in an enrichment of a pro-regenerating consortium of bacteria, which augments mucosal wound repair and restoration of barrier functions.
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“Further, they have been shown to significantly influence the maintenance of gut barrier integrity itself and intestinal homeostasis.73,74”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [73]
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Heidbreder, K., Sommer, K., Wiendl, M., Müller, T. M., Atreya, I., Hildner, K., Neurath, M. F., & Zundler, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1040775 · Cited by 8
Li, D., Yao, H., Li, Y., Li, Z., Yang, X., Zhu, X., & Zeng, X. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-24994-3 · Cited by 8
High-fat diet feeding exacerbates HIV-1 rectal transmission
Lohani, S. C., Ramer‐Tait, A. E., & Li, Q. (2024) · mSystems · doi:10.1128/msystems.01322-23 · Cited by 8
Song, J., Lee, D., Hwang, B., Kim, S., Kim, J., Park, S., Choo, S., Hwang, S.-K., Kim, H., Yun, S. J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-11700-9 · Cited by 8
Raman, M., Ma, C., Taylor, L. M., Dieleman, L. A., Gkoutos, G. V., Vallance, J. K., McCoy, K. D., Lewis, I., Jijon, H., McKay, D. M., et al. (2022) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2021-000841 · Cited by 7
Huang, H., Zhou, L., Yu, Y., Liu, S., Xu, H., Xu, Z., Yang, C., & Liu, C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.789597 · Cited by 7
Sen, A., Goforth, M., Cooper, K. K., & Anakk, S. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac145 · Cited by 7
Yang, J., Zheng, X., Liu, X., Zhou, Q., Sun, C., Song, C., Wang, A., & Liu, B. (2024) · Water Biology and Security · doi:10.1016/j.watbs.2024.100340 · Cited by 8
The microbiota, the malarial parasite, and the mice—a three-sided relationship
He, S., & Qi, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1615846 · Cited by 7
Jia, Y., Cao, J., Guo, Y. P., Wu, L., Du, X., Tang, B., Xia, B., & Deng, Y. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1470502 · Cited by 7
Krom, H., van den Hoek, C. M. W., Benninga, M. A., Delemarre, E. A., de Jong, J. R., Koot, B. G. P., Tabbers, M. M., Voogt, H., & Kindermann, A. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002709 · Cited by 6
Gut Microbiota and Inflammatory Disorders
Krishna, V., Kumar, N., & Banerjee, S. (2021) · Current Drug Targets · doi:10.2174/1389450122666210623125603 · Cited by 6
Boatman, S. M., Khan, M. H., Ganesan, N., Nalluri, H., Kohn, J. F., Troester, A. M., Ziegert, Z., Madoff, R. D., Gaertner, W. B., Jahansouz, C., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-72520-x · Cited by 5
Ren, M., Ji, C., Jiang, C., Zhang, F., Yu, Q., Hu, Q., Zhao, C., Ghonaim, A. H., & Li, S. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105688 · Cited by 5
Li, L., Lei, B., Zhang, W., Wang, W., Shang, C., Hu, Y., Zhao, K., & Yuan, W. (2024) · Poultry Science · doi:10.1016/j.psj.2024.104428 · Cited by 5
Metadata
- Authors
- Alam, A., & Neish, A.
- Affiliations
- Emory University (US)
- Corresponding author
- Alam, Ashfaqul
- Venue
- Tissue Barriers
- Publisher
- Informa UK Limited
- Published
- 2018-07-03
- Volume
- 6
- Issue
- 3
- Pages
- 1539595
- ISSN
- 2168-8362 (ISSN-L)
- 2168-8370
- PMC
- PMC6389125
- OpenAlex
- W2899740161
- Cited by
- 166
- References
- 152
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 28 · 2023: 20 · 2022: 26 · 2021: 40 · 2020: 12 · 2019: 9
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Tissue Barriers (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (5R01CA179424)
- National Institutes of Health (R01AI064462, K01DK114391)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- gut microbiota, intestinal barrier function, intestinal wound healing, mucosal regeneration, dysbiosis, intestinal diseases, mucosal injury, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Intestinal Mucosa, Wound Healing
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