Cited by 167Gut microbiota and healthGastrointestinal motility and disordersInflammatory Bowel Disease

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Role of gut microbiota in intestinal wound healing and barrier function

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Alam, Ashfaqul, Neish, Andrew·2018·Tissue Barriers

DOI 10.1080/21688370.2018.1539595PMC PMC6389125

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Abstract

The mammalian intestine harbors a highly complex and abundant ensemble of bacteria that flourish in a nutrient-rich environment while profoundly influencing many aspects of host biology. The intestine coevolved with its resident microbes in a manner where the mucosa developed a barrier function to segregate the resident microbes from the rest of the body, and yet paradoxically, allowing integration of microbial signals for the host benefit. In this review, we provided a comprehensive overview of why the gut microbiota is key to the efficient development and maintenance of the intestinal barrier. We also highlighted how a destabilized equilibrium between gut microbiota and the host may eventuate in a wide range of intestinal diseases characterized by the disrupted intestinal barrier. Finally, the review delineated how microenvironmental changes in the injured mucosa result in an enrichment of a pro-regenerating consortium of bacteria, which augments mucosal wound repair and restoration of barrier functions.

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Authors: Alam, A., & Neish, A.
Affiliations: Emory University (US)
Corresponding author: Alam, Ashfaqul
ORCID: Alam, Ashfaqul
Neish, Andrew
Venue: Tissue Barriers
Publisher: Informa UK Limited
Published: 2018-07-03
Volume: 6
Issue: 3
Pages: 1539595
ISSN: 2168-8362 (ISSN-L)
2168-8370
DOI: 10.1080/21688370.2018.1539595
PMC: PMC6389125
OpenAlex: W2899740161
Cited by: 166
References: 152
Citations by year: 2026: 14 · 2025: 17 · 2024: 28 · 2023: 20 · 2022: 26 · 2021: 40 · 2020: 12 · 2019: 9
FWCI: 1.49
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Tissue Barriers (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (5R01CA179424)
National Institutes of Health (R01AI064462, K01DK114391)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: gut microbiota, intestinal barrier function, intestinal wound healing, mucosal regeneration, dysbiosis, intestinal diseases, mucosal injury, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Intestinal Mucosa, Wound Healing

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Role of gut microbiota in intestinal wound healing and barrier function

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