Cited by 313Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

Fungal ß(1,3)-D-glucan synthesis

Douglas, C. M.·2001·Medical Mycology

Abstract

The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. Synthesis of the linear polymer is catalysed by UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. Because this enzyme has a key role in fungal cell-wall synthesis, and because many organisms that are responsible for human mycoses, including Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, produce walls that are rich in beta(1,3)-glucan, it has been and remains the focus of intensive study. From early characterization of the enzymatic activity in Saccharomyces cerevisiae, advances have been made in purification of the enzyme, identification of essential subunits and description of regulatory circuitry that controls expression and localization of different components of the multisubunit enzyme complex. Progress in each of these areas has been enhanced dramatically by the availability of specific inhibitors of the enzymatic reaction that produces beta(1,3)-glucan. These natural product inhibitors have utility both as tools to dissect the biology of beta(1,3)-glucan synthase and as sources for development of semisynthetic derivatives with clinical utility in treatment of human fungal disease. This review will focus on the biochemistry, genetics and regulation of the enzyme.

Integrity signals

Registry

Crossref · 10.1080/mmy.39.1.55.66

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • It has only been conclusively demonstrated that FKS mutations are sufficient to confer echinocandin resistance in S. cerevisiae.

    “While there is an association of FKS mutations with resistance, and biochemical data support the resistance mechanism, it has only been conclusively demonstrated that such mutations are sufficient to confer echinocandin resistance in S. cerevisiae [82], [83].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Douglas, C. M.
Affiliations
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Corresponding author
Douglas, C. M.
Venue
Medical Mycology
Published
2001-01
Volume
39
Issue
1
Pages
55-66
ISSN
  • 0268-1218 (ISSN-L)
  • 1369-3786
  • 1460-2709
OpenAlex
W2143508569
Cited by
312
References
100
Citations by year
2026: 14 · 2025: 17 · 2024: 16 · 2023: 12 · 2022: 12 · 2021: 13 · 2020: 22 · 2019: 8 · 2018: 14 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 16 · 2013: 15 · 2012: 19
FWCI
0.54
Type
journal article
Language
en
Open access
closed
Locations
  • Medical Mycology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
β-1,3-glucan, fungal cell wall, enzyme regulation, enzyme subunits, enzyme inhibitors, Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, Saccharomyces cerevisiae, human fungal diseases
MeSH terms
Fungal Proteins, Fungi, Glucans, Glucosyltransferases, Membrane Proteins, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae Proteins, beta-Glucans, Echinocandins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review