The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
Differentiation and Death of Premyelinating Oligodendrocytes in Developing Rodent Brain
Open accessAbstract
Previous studies have indicated that newly formed oligodendrocytes are dynamic cells whose production, survival, and differentiation depend upon axonal influences. This study has characterized the appearance and fate of newly formed oligodendrocytes in developing rat brain. Oligodendrocytes appear in predictable locations and radially extend DM-20-positive processes that cover 80-microm domains in the cortex and 40-microm domains in the corpus callosum. These premyelinating oligodendrocytes have one of two fates: they myelinate axons or degenerate. Between 7 and 21 d after birth, approximately 20% of premyelinating oligodendrocytes identified in the cerebral cortex were degenerating. Oligodendrocytes that ensheathed axons expressed and selectively targeted proteolipid protein to compact myelin and did not degenerate. These observations support the hypothesis that axonal influences affect oligodendrocyte survival, differentiation, and expression of proteolipid protein gene products.
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“In the developing neocortex, ∼20% of premyelinating OLs die between P7 and P11 (Trapp et al., 1997).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Trapp et al., 1997
Experimental — accuracy not yet measuredIn the citing paper
“The timing of their appearance coincides with the onset of myelination, during which large numbers of newly formed oligodendrocytes die (Barres et al., 1992; Trapp et al., 1997).”
From Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing (2019) · cites this paper as Trapp et al., 1997
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Citations
Cites
RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030
Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System
RAFF, M. C., Barres, B. A., Burne, J. F., Coles, H., Ishizaki, Y., & Jacobson, M. D. (1993) · Science · doi:10.1126/science.8235590 · Cited by 1,450
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
A role for platelet-derived growth factor in normal gliogenesis in the central nervous system
Richardson, W. D., Pringle, N. P., Mosley, M. J., Westermark, B., & Dubois-Dalcg, M. (1988) · Cell · doi:10.1016/0092-8674(88)90392-3 · Cited by 774
The oligodendrocyte and its many cellular processes
PFEIFFER, S., WARRINGTON, A., & BANSAL, R. (1993) · Trends in Cell Biology · doi:10.1016/0962-8924(93)90213-k · Cited by 737
Levison, S. W., & Goldman, J. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90311-e · Cited by 725
Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons
Barres, B. A., & Raff, M. C. (1993) · Nature · doi:10.1038/361258a0 · Cited by 673
Pringle, N. P., & Richardson, W. D. (1993) · Development · doi:10.1242/dev.117.2.525 · Cited by 510
Pringle, N. P., Mudhar, H. S., Collarini, E. J., & Richardson, W. D. (1992) · Development · doi:10.1242/dev.115.2.535 · Cited by 443
Polarity of Epithelial and Neuronal Cells
Rodriguez-Boulan, E. J., & Powell, S. K. (1992) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.08.110192.002143 · Cited by 430
Synthesis and incorporation of myelin polypeptides into CNS myelin.
Colman, D., Kreibich, G., Frey, A. B., & Sabatini, D. D. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.2.598 · Cited by 424
Control of oligodendrocyte number in the developing rat optic nerve
Barres, B. A., & RAFF, M. C. (1994) · Neuron · doi:10.1016/0896-6273(94)90305-0 · Cited by 393
Does oligodendrocyte survival depend on axons?
Barres, B. A., Jacobson, M. D., Schmid, R., Sendtner, M., & RAFF, M. C. (1993) · Current Biology · doi:10.1016/0960-9822(93)90039-q · Cited by 310
Timsit, S., Martı́nez, S., Allinquant, B., Peyron, F., Puelles, L., & Zalc, B. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01012.1995 · Cited by 302
Development and differentiation of glial precursor cells in the rat cerebellum
Levine, J. M., Stincone, F., & Lee, Y. (1993) · Glia · doi:10.1002/glia.440070406 · Cited by 282
Plasma membrane protein sorting in polarized epithelial cells.
Mostov, K. E., Apodaca, G., Aroeti, B., & Okamoto, C. T. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.3.577 · Cited by 272
Sternberger, N. H., Itoyama, Y., Kies, M. W., & Webster, H. D. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.5.2521 · Cited by 270
Gard, A. L., & Pfeiffer, S. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90216-3 · Cited by 262
Hardy, R., & Reynolds, R. (1991) · Development · doi:10.1242/dev.111.4.1061 · Cited by 251
Trapp, B. D., Andrews, S., Cootauco, C., & Quarles, R. H. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.5.2417 · Cited by 247
Self-citationNishiyama, A., Lin, X., Giese, N. A., Heldin, C., & Stallcup, W. B. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960201)43:3 · Cited by 244
Self-citationSpatial segregation of mRNA encoding myelin-specific proteins.
Trapp, B. D., Moench, T. R., Pulley, M., Barbosa, E., Tennekoon, G., & Griffin, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7773 · Cited by 234
Self-citationPDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage
Hart, I. K., Richardson, W. D., Heldin, C., Westermark, B., & RAFF, M. C. (1989) · Development · doi:10.1242/dev.105.3.595 · Cited by 233
Miller, R. H. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80036-1 · Cited by 224
Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit
Knapp, P. E., Skoff, R. P., & Redstone, D. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02813.1986 · Cited by 212
Bansal, R., Stefánsson, K., & Pfeiffer, S. E. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10967.x · Cited by 185
Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum
LeVine, S. M., & Goldman, J. E. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902770309 · Cited by 173
Gard, A. L., & Pfeiffer, S. E. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1269 · Cited by 170
Glial cells are increased proportionally in transgenic optic nerves with increased numbers of axons
Burne, J. F., Staple, J., & RAFF, M. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02064.1996 · Cited by 151
Kitagawa, K., Sinoway, M. P., Yang, C., Gould, R. M., & Colman, D. (1993) · Neuron · doi:10.1016/0896-6273(93)90148-k · Cited by 150
PDGF and intracellular signaling in the timing of oligodendrocyte differentiation.
Hart, I. K., Richardson, W. D., Bolsover, S. R., & RAFF, M. C. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.3411 · Cited by 150
ACCUMULATION OF THE FOUR MYELIN BASIC PROTEINS IN MOUSE BRAIN DURING DEVELOPMENT1
Barbarese, E., Carson, J. H., & Braun, P. E. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb00110.x · Cited by 147
Molecular cloning of M6: Identification of a PLP/DM20 gene family
Yan, Y., Lagenaur, C. F., & Narayanan, V. (1993) · Neuron · doi:10.1016/0896-6273(93)90147-j · Cited by 143
Warrington, A. E., & Pfeiffer, S. E. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490330218 · Cited by 141
Increased proliferation of oligodendrocytes in the hypomyelinated mouse mutant-jimpy
Skoff, R. P. (1982) · Brain Research · doi:10.1016/0006-8993(82)91143-x · Cited by 121
Hardy, R. J., & Friedrich, V. L. (1996) · Development · doi:10.1242/dev.122.7.2059 · Cited by 104
Yoshida, M., & Colman, D. (1996) · Neuron · doi:10.1016/s0896-6273(00)80138-5 · Cited by 101
Myelin-associated glycoprotein: A developmental change
Quarles, R. H., Everly, J. L., & Brady, R. O. (1973) · Brain Research · doi:10.1016/0006-8993(73)90022-x · Cited by 93
Axons regulate the distribution of Schwann cell microtubules
Kidd, G., Andrews, S., & Trapp, B. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00946.1996 · Cited by 23
Self-citationffrench‐Constant, C. (1992) · Current Biology · doi:10.1016/0960-9822(92)90150-9 · Cited by 9
Flagged first, then by citations
1 of the 41 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Nishiyama, 1996, Interaction between NG2 proteoglycan and PDGF α receptor on 02A progenitor cells is required for optimal response to PDGF, J Neurosci Res, 43, 315, 10.1002/(SICI)1097-4547(19960201)43:3<315::AID-JNR6>3.0.CO;2-M · DOI
Cited by
Sorted by citations
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Self-citationBiology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Li, Q., Cheng, Z., Zhou, L., Darmanis, S., Neff, N. F., Okamoto, J., Gulati, G., Bennett, M. L., Sun, L. O., Clarke, L. E., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.006 · Cited by 1,129
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991
Self-citationOligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919
“Therefore, if the main function of adult-born OLs is to myelinate previously unmyelinated axons, then we should not expect much OL genesis in the optic nerve after P112 because there should be almost no naked axons available to myelinate.”
Background
Metadata
- Authors
- Trapp, B. D., Nishiyama, A., Cheng, D., & Macklin, W.
- Affiliations
- Cleveland Clinic (US)
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1997-04-21
- Volume
- 137
- Issue
- 2
- Pages
- 459-468
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2139778
- OpenAlex
- W2097849969
- Cited by
- 395
- References
- 41
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 9 · 2023: 16 · 2022: 14 · 2021: 23 · 2020: 26 · 2019: 16 · 2018: 13 · 2017: 15 · 2016: 12 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 7
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Cell Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society
- Multiple Sclerosis Society
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS25304, R01NS029818, R01NS025304, NS 29818)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- oligodendrocyte differentiation, oligodendrocyte death, myelination, proteolipid protein, DM20, oligodendrocyte survival, cerebral cortex, corpus callosum, postnatal brain development
- MeSH terms
- Animals, Axons, Brain, Cell Differentiation, Cerebral Cortex, Chromatin, Corpus Callosum, Nerve Tissue Proteins, Oligodendroglia, Cell Death, Rats, Sprague-Dawley, Myelin Proteolipid Protein, Rats
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