CoChat
Sign Up
Cited by 163

The DOI matches its Crossref record.

Uncovering multiple axonal targeting pathways in hippocampal neurons

Wisco, Dolora, Anderson, Eric D., Chang, Michael C., Norden, Caren, Boiko, Tatiana, Fölsch, Heike, Winckler, Bettina·2003·The Journal of Cell Biology
DOI 10.1083/jcb.200307069PMC PMC2173963
Open this paper in CoChat — free account

Abstract

Neuronal polarity is, at least in part, mediated by the differential sorting of membrane proteins to distinct domains, such as axons and somata/dendrites. We investigated the pathways underlying the subcellular targeting of NgCAM, a cell adhesion molecule residing on the axonal plasma membrane. Following transport of NgCAM kinetically, surprisingly we observed a transient appearance of NgCAM on the somatodendritic plasma membrane. Down-regulation of endocytosis resulted in loss of axonal accumulation of NgCAM, indicating that the axonal localization of NgCAM was dependent on endocytosis. Our data suggest the existence of a dendrite-to-axon transcytotic pathway to achieve axonal accumulation. NgCAM mutants with a point mutation in a crucial cytoplasmic tail motif (YRSL) are unable to access the transcytotic route. Instead, they were found to travel to the axon on a direct route. Therefore, our results suggest that multiple distinct pathways operate in hippocampal neurons to achieve axonal accumulation of membrane proteins.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1083/jcb.200307069

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • L1/NgCAM reaches the axon indirectly by transcytosis, involving initial somatodendritic targeting followed by endocytosis and trafficking to the axon from somatodendritic endosomes.

    “L1/NgCAM reaches the axon indirectly by transcytosis, involving initial somatodendritic targeting followed by endocytosis and trafficking to the axon from somatodendritic endosomes (Wisco et al., 2003; Yap et al., 2008a; Yap et al., 2008b).”

    From Alterations of EHD1/EHD4 Protein Levels Interfere with L1/NgCAM Endocytosis in Neurons and Disrupt Axonal Targeting (2010) · cites this paper as Wisco et al., 2003

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 44

  1. 2000, Neuron., 26, 465, 10.1016/S0896-6273(00)81178-2 · DOI
  2. 1990, Science., 248, 742, 10.1126/science.2110383 · DOI
  3. 1999, Cell., 97, 153, 10.1016/S0092-8674(00)80724-2 · DOI · Paper page
  4. 2002, J. Neurosci., 22, 10643, 10.1523/JNEUROSCI.22-24-10643.2002 · DOI
  5. 1995, J. Neurosci., 15, 4259, 10.1523/JNEUROSCI.15-06-04259.1995 · DOI
  6. 1999, Neuron., 23, 649, 10.1016/S0896-6273(01)80024-6 · DOI
  7. 1994, Annu. Rev. Neurosci., 17, 267, 10.1146/annurev.ne.17.030194.001411 · DOI
  8. 1995, Methods Enzymol., 257, 209, 10.1016/S0076-6879(95)57026-8 · DOI
  9. 1995, J. Cell Biol., 130, 1447, 10.1083/jcb.130.6.1447 · DOI
  10. 1999, J. Neurosci., 19, 4907, 10.1523/JNEUROSCI.19-12-04907.1999 · DOI
  11. 2002, J. Cell Biol., 157, 1105, 10.1083/jcb.200111076 · DOI · Paper page
  12. 1990, Cell., 62, 63, 10.1016/0092-8674(90)90240-F · DOI
  13. 1999, Cell., 99, 189, 10.1016/S0092-8674(00)81650-5 · DOI · Paper page
  14. 2003, J. Biol. Chem., 278, 12222, 10.1074/jbc.M205663200 · DOI
  15. 2002, J. Neurosci., 22, 2196, 10.1523/JNEUROSCI.22-06-02196.2002 · DOI
  16. 2001, EMBO J., 20, 5950, 10.1093/emboj/20.21.5950 · DOI
  17. 1997, J. Neurosci., 17, 8955, 10.1523/JNEUROSCI.17-23-08955.1997 · DOI
  18. 1998, Neuron., 20, 855, 10.1016/S0896-6273(00)80468-7 · DOI
  19. 1998, J. Neurosci., 18, 3749, 10.1523/JNEUROSCI.18-10-03749.1998 · DOI
  20. 2000, J. Neurosci., 20, 3676, 10.1523/JNEUROSCI.20-10-03676.2000 · DOI
  21. 1998, J. Neurosci, 18, 5311, 10.1523/JNEUROSCI.18-14-05311.1998 · DOI
  22. 1992, J. Cell Biol., 116, 1071, 10.1083/jcb.116.5.1071 · DOI
  23. 1998, Mol. Biol. Cell., 9, 1787, 10.1091/mbc.9.7.1787 · DOI
  24. 1992, Cell., 71, 741, 10.1016/0092-8674(92)90551-M · DOI · Paper page
  25. 1994, J. Cell Biol., 126, 991, 10.1083/jcb.126.4.991 · DOI
  26. 1993, Cell., 74, 1053, 10.1016/0092-8674(93)90727-8 · DOI · Paper page
  27. 1995, Cold Spring Harb. Symp. Quant. Biol., 60, 745, 10.1101/SQB.1995.060.01.080 · DOI
  28. 2003, Nat. Cell Biol., 5, 287, 10.1038/ncb0403-287 · DOI
  29. 1995, Bioessays., 17, 129, 10.1002/bies.950170208 · DOI
  30. 1999, FEBS Lett., 449, 215, 10.1016/S0014-5793(99)00432-9 · DOI · Paper page
  31. 2003, Neuron., 37, 611, 10.1016/S0896-6273(03)00058-8 · DOI
  32. 1997, Cell., 90, 1137, 10.1016/S0092-8674(00)80379-7 · DOI
  33. 2002, J. Cell Biol., 157, 1223, 10.1083/jcb.200203024 · DOI
  34. 2000, J. Neurosci., 20, 4177, 10.1523/JNEUROSCI.20-11-04177.2000 · DOI
  35. 1992, J. Cell Biol., 118, 531, 10.1083/jcb.118.3.531 · DOI
  36. 1999, Neuron., 22, 525, 10.1016/S0896-6273(00)80707-2 · DOI
  37. 1996, EMBO J., 15, 5218, 10.1002/j.1460-2075.1996.tb00907.x · DOI
  38. 2003, Physiol. Rev., 83, 871, 10.1152/physrev.00001.2003 · DOI · Paper page
  39. 2002, Dev. Cell., 2, 219, 10.1016/S1534-5807(02)00115-6 · DOI
  40. 1996, Curr. Biol., 6, 1153, 10.1016/S0960-9822(02)70682-9 · DOI
  41. 1990, J. Cell Biol., 111, 987, 10.1083/jcb.111.3.987 · DOI
  42. 1997, J. Neurosci., 17, 6038, 10.1523/JNEUROSCI.17-16-06038.1997 · DOI
  43. 1999, Neuron., 23, 637, 10.1016/S0896-6273(01)80021-0 · DOI
  44. 1999, Nature., 397, 698, 10.1038/17806 · DOI

Cited by

Sorted by citations

Metadata

Authors
Wisco, D., Anderson, E. D., Chang, M. C., Norden, C., Boiko, T., Fölsch, H., & Winckler, B.
Affiliations
  • 1Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029
  • 2Department of Cell Biology, Yale Medical School, New Haven, CT 06520
Venue
The Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2003-09-29
Volume
162
Issue
7
Pages
1317-1328
ISSN
  • 1540-8140
  • 0021-9525
DOI
10.1083/jcb.200307069
PMC
PMC2173963
Cited by
163
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review