MCAK associates with the tips of polymerizing microtubules
Open accessAbstract
MCAK is a member of the kinesin-13 family of microtubule (MT)-depolymerizing kinesins. We show that the potent MT depolymerizer MCAK tracks (treadmills) with the tips of polymerizing MTs in living cells. Tip tracking of MCAK is inhibited by phosphorylation and is dependent on the extreme COOH-terminal tail of MCAK. Tip tracking is not essential for MCAK's MT-depolymerizing activity. We propose that tip tracking is a mechanism by which MCAK is preferentially localized to regions of the cell that modulate the plus ends of MTs.
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Overexpression of a dominant negative MCAK mutant led to a modest increase in chromosome missegregation in MDA-MB-231 cells.
“whereas overexpression of a dominant negative MCAK mutant12 (dnMCAK) led to a modest increase in chromosome missegregation in MDA-MB-231 cells.”
From Chromosomal instability drives metastasis through a cytosolic DNA response (2018) · cites this paper as [12]
MCAK plus-end tracking requires interaction between MCAK and members of the end-binding protein (EB) family.
“This plus-end tracking behavior requires the interaction between MCAK and members of the end-binding protein (EB) family [5-8]”
From In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends (2010) · cites this paper as [5]
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- Authors
- Moore, A. T., Rankin, K. E., von Dassow, G., Peris, L., Wagenbach, M., Ovechkina, Y., Andrieux, A., Job, D., & Wordeman, L.
- Affiliations
- University of Washington (US)
- 2Center for Cell Dynamics, Friday Harbor Labs, University of Washington, Friday Harbor, WA 98250
- Inserm (FR)
- Corresponding author
- Wordeman, Linda
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-05-09
- Volume
- 169
- Issue
- 3
- Pages
- 391-397
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2171944
- OpenAlex
- W2151206507
- Cited by
- 141
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 12
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (GM-07270, F31GM065061, T32GM007270, P50GM066050, R01GM069429, GM69429, GM65061, GM066050)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- MCAK, kinesin-13, microtubule depolymerization, microtubule plus ends, microtubule assembly, phosphorylation, protein localization, microtubule dynamics
- MeSH terms
- Animals, Cell Compartmentation, Cricetinae, HeLa Cells, Humans, Microtubules, Phosphorylation, Polymers, Recombinant Fusion Proteins, CHO Cells, Kinesins, Cell Polarity, Protein Structure, Tertiary, Microscopy, Video, Protein Transport, Green Fluorescent Proteins
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