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Compartmentalization of androgen receptor protein–protein interactions in living cells
Open accessAbstract
Steroid receptors regulate gene expression in a ligand-dependent manner by binding specific DNA sequences. Ligand binding also changes the conformation of the ligand binding domain (LBD), allowing interaction with coregulators via LxxLL motifs. Androgen receptors (ARs) preferentially interact with coregulators containing LxxLL-related FxxLF motifs. The AR is regulated at an extra level by interaction of an FQNLF motif in the N-terminal domain with the C-terminal LBD (N/C interaction). Although it is generally recognized that AR coregulator and N/C interactions are essential for transcription regulation, their spatiotemporal organization is largely unknown. We performed simultaneous fluorescence resonance energy transfer and fluorescence redistribution after photobleaching measurements in living cells expressing ARs double tagged with yellow and cyan fluorescent proteins. We provide evidence that AR N/C interactions occur predominantly when ARs are mobile, possibly to prevent unfavorable or untimely cofactor interactions. N/C interactions are largely lost when AR transiently binds to DNA, predominantly in foci partly overlapping transcription sites. AR coregulator interactions occur preferentially when ARs are bound to DNA.
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Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes & Development · doi:10.1101/gad.1424806 · Cited by 952
The glucocorticoid receptor: rapid exchange with regulatory sites in living cells
McNally, J. G., Müller, W. G., Walker, D., Wolford, R., & Hager, G. L. (2000) · Science · doi:10.1126/science.287.5456.1262 · Cited by 802 · cited 4×
“…resonance energy transfer (FRET), have been instrumental in the investigation of the behavior of SRs in living cells (Georget et al., 1997; McNally et al., 2000; Stenoien et al., 2001; Schaaf and Cidlowski, 2003; Farla et al., 2004, 2005; Michalides et al., 2004; Agresti et al., 2005;…”
BackgroundInfluentialSchaufele, F., Carbonell, X., Guerbadot, M., Borngraeber, S., Chapman, M. S., Ma, A. A. K., Miner, J. N., & Diamond, M. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408819102 · Cited by 208
Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor
Dubbink, H. J., Hersmus, R., Verma, C. S., van der Korput, H. A. G. M., Berrevoets, C. A., van Tol, J., Ziel-van der Made, A. C. J., Brinkmann, A. O., Pike, A. C. W., & Trapman, J. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0375 · Cited by 118
Self-citation
Research works printed but not linked: 33
- 2005, Mol. Cell., 18, 109, 10.1016/j.molcel.2005.03.005 · DOI
- 2007, Mol. Endocrinol., 21, 14, 10.1210/me.2006-0041 · DOI
- 1996, Proc. Natl. Acad. Sci. USA., 93, 8407, 10.1073/pnas.93.16.8407 · DOI · Paper page
- 1996, EMBO J., 15, 4246, 10.1002/j.1460-2075.1996.tb00799.x · DOI · Paper page
- 1989, J. Steroid Biochem., 34, 307, 10.1016/0022-4731(89)90098-8 · DOI · Paper page
- 2006, Nat. Genet., 38, 1289, 10.1038/ng1901 · DOI · Paper page
- 2001, J. Steroid Biochem. Mol. Biol., 76, 23, 10.1016/S0960-0760(00)00154-0 · DOI · Paper page
- 1997, Mol. Endocrinol., 11, 148, 10.1210/mend.11.2.9883 · DOI · Paper page
- 1997, Biochemistry., 36, 1052, 10.1021/bi961775g · DOI · Paper page
- 2004, J. Struct. Biol., 147, 50, 10.1016/j.jsb.2004.01.002 · DOI
- 2005, J. Cell Sci., 118, 4187, 10.1242/jcs.02546 · DOI
- 1997, Mol. Cell. Endocrinol., 129, 17, 10.1016/S0303-7207(97)04034-3 · DOI · Paper page
- 1997, J. Cell Sci., 110, 1781, 10.1242/jcs.110.15.1781 · DOI · Paper page
- 2000, J. Biol. Chem., 275, 22986, 10.1074/jbc.M002807200 · DOI · Paper page
- 2001, J. Biol. Chem., 276, 42293, 10.1074/jbc.M107492200 · DOI
- 2002, J. Biol. Chem., 277, 10226, 10.1074/jbc.M111975200 · DOI · Paper page
- 1999, Science., 284, 958, 10.1126/science.284.5416.958 · DOI · Paper page
- 2001, Histochem. Cell Biol., 115, 13, 10.1007/s004180000234 · DOI · Paper page
- 2004, PLoS Biol., 2, E274, 10.1371/journal.pbio.0020274 · DOI · Paper page
- 1993, EMBO J., 12, 1059, 10.1002/j.1460-2075.1993.tb05747.x · DOI · Paper page
- 1999, J. Biol. Chem., 274, 8570, 10.1074/jbc.274.13.8570 · DOI · Paper page
- 2001, Methods., 24, 289, 10.1006/meth.2001.1189 · DOI · Paper page
- 2006, J. Cell. Biochem., 98, 770, 10.1002/jcb.20593 · DOI
- 2006, EMBO Rep., 7, 161, 10.1038/sj.embor.7400626 · DOI · Paper page
- 2004, Cancer Cell., 5, 597, 10.1016/j.ccr.2004.05.016 · DOI · Paper page
- 2004, Mol. Cell. Biol., 24, 6393, 10.1128/MCB.24.14.6393-6402.2004 · DOI · Paper page
- 2005, Mol. Cell. Biol., 25, 2406, 10.1128/MCB.25.6.2406-2418.2005 · DOI
- 2003, Mol. Cell. Biol., 23, 1922, 10.1128/MCB.23.6.1922-1934.2003 · DOI · Paper page
- 2001, Nat. Cell Biol., 3, 15, 10.1038/35050515 · DOI · Paper page
- 1999, J. Biol. Chem., 274, 9449, 10.1074/jbc.274.14.9449 · DOI
- 2006, J. Biol. Chem., 281, 19407, 10.1074/jbc.M602567200 · DOI
- 1995, J. Cell Sci., 108, 3003, 10.1242/jcs.108.9.3003 · DOI
- 1993, J. Cell Biol., 122, 283, 10.1083/jcb.122.2.283 · DOI · Paper page
Cited by
Heemers, H. V., & Tindall, D. J. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0019 · Cited by 753
Molecular cell biology of androgen receptor signalling
Bennett, N. C., Gardiner, R. A., Hooper, J. D., Johnson, D. W., & Gobe, G. C. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.013 · Cited by 292
Structure of the homodimeric androgen receptor ligand-binding domain
Nadal, M., Prekovic, S., Gallastegui, N., Helsen, C., Abella, M., Zielinska, K., Gay, M., Vilaseca, M., Taulès, M., Houtsmuller, A. B., et al. (2017) · Nature Communications · doi:10.1038/ncomms14388 · Cited by 193
Self-citationStepwise androgen receptor dimerization
van Royen, M. E., van Cappellen, W. A., de Vos, C., Houtsmuller, A. B., & Trapman, J. (2012) · Journal of Cell Science · doi:10.1242/jcs.096792 · Cited by 143
Self-citationAllosteric Modulators of Steroid Hormone Receptors: Structural Dynamics and Gene Regulation
Kumar, R., & McEwan, I. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1033 · Cited by 135
Metadata
- Authors
- van Royen, M. E., Cunha, S. M., Brink, M. C., Mattern, K. A., Nigg, A. L., Dubbink, H. J., Verschure, P. J., Trapman, J., & Houtsmuller, A. B.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-04-09
- Volume
- 177
- Issue
- 1
- Pages
- 63-72
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1988467765
- Cited by
- 170
- References
- 4
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- green
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- van Royen, M. E., Cunha, S. M., Brink, M. C., Mattern, K. A., Nigg, A. L., Dubbink, H. J., Verschure, P. J., Trapman, J., & Houtsmuller, A. B. (2007). Compartmentalization of androgen receptor protein–protein interactions in living cells. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200609178
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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