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Cited by 507

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development

Open access
Ge, Chunxi, Xiao, Guozhi, Jiang, Di, Franceschi, Renny T.·2007·The Journal of Cell Biology
DOI 10.1083/jcb.200610046
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Abstract

The extracellular signal–regulated kinase (ERK)–mitogen-activated protein kinase (MAPK) pathway provides a major link between the cell surface and nucleus to control proliferation and differentiation. However, its in vivo role in skeletal development is unknown. A transgenic approach was used to establish a role for this pathway in bone. MAPK stimulation achieved by selective expression of constitutively active MAPK/ERK1 (MEK-SP) in osteoblasts accelerated in vitro differentiation of calvarial cells, as well as in vivo bone development, whereas dominant-negative MEK1 was inhibitory. The involvement of the RUNX2 transcription factor in this response was established in two ways: (a) RUNX2 phosphorylation and transcriptional activity were elevated in calvarial osteoblasts from TgMek-sp mice and reduced in cells from TgMek-dn mice, and (b) crossing TgMek-sp mice with Runx2+/− animals partially rescued the hypomorphic clavicles and undemineralized calvaria associated with Runx2 haploinsufficiency, whereas TgMek-dn; Runx2+/− mice had a more severe skeletal phenotype. This work establishes an important in vivo function for the ERK–MAPK pathway in bone that involves stimulation of RUNX2 phosphorylation and transcriptional activity.

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Metadata

Authors
Ge, C., Xiao, G., Jiang, D., & Franceschi, R. T.
Venue
The Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2007-02-26
Volume
176
Issue
5
Pages
709-718
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.200610046
OpenAlex
W2108281583
Cited by
507
References
50
FWCI
8.86
Type
journal article
Language
en
Open access
green

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