Recent insights into the cellular biology of atherosclerosis

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Atherosclerosis

Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026

Atherosclerosis

Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,094

Macrophages in the Pathogenesis of Atherosclerosis

Moore, K. J., & Tabas, I. (2011) · Cell · doi:10.1016/j.cell.2011.04.005 · Cited by 2,669

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

Tabas, I. A., & Ron, D. (2011) · Nature Cell Biology · doi:10.1038/ncb0311-184 · Cited by 2,655

The immune system in atherosclerosis

Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,389

Nonresolving Inflammation

Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183

Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities

Braunwald, E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711063371906 · Cited by 1,426

The Response-to-Retention Hypothesis of Early Atherogenesis

Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413

Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis: Update and Therapeutic Implications

Tabas, I., Williams, K. J., & Borén, J. (2007) · Circulation · doi:10.1161/circulationaha.106.676890 · Cited by 1,399

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323

Piezo1 integration of vascular architecture with physiological force

Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A. F., Ludlow, M. J., Sedó, A., Hyman, A. J., McKeown, L., Young, R. S., et al. (2014) · Nature · doi:10.1038/nature13701 · Cited by 1,250

Macrophage death and defective inflammation resolution in atherosclerosis

Tabas, I. (2010) · Nature Reviews Immunology · doi:10.1038/nri2675 · Cited by 1,120

Myocardial infarction accelerates atherosclerosis

Dutta, P., Courties, G., Wei, Y., Leuschner, F., Gorbatov, R., Robbins, C. S., Iwamoto, Y., Thompson, B. D., Carlson, A. L., Heidt, T., et al. (2012) · Nature · doi:10.1038/nature11260 · Cited by 1,109

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

Tabas, I., & Glass, C. K. (2013) · Science · doi:10.1126/science.1230720 · Cited by 1,093

Update on acute coronary syndromes: the pathologists' view

Falk, E., Nakano, M., Bentzon, J. F., Finn, A. V., & Virmani, R. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs411 · Cited by 1,047

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

Robbins, C. S., Hilgendorf, I., Weber, G. F., Theurl, I., Iwamoto, Y., Figueiredo, J.-L., Gorbatov, R., Sukhova, G. K., Gerhardt, L. M. S., Smyth, D., et al. (2013) · Nature Medicine · doi:10.1038/nm.3258 · Cited by 1,041

Insulin Resistance, Hyperglycemia, and Atherosclerosis

Bornfeldt, K., & Tabas, I. A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.015 · Cited by 1,020

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

Sheedy, F. J., Grebe, A., Rayner, K. J., Kalantari, P., Ramkhelawon, B., Carpenter, S. B., Becker, C. E., Ediriweera, H. N., Mullick, A. E., Golenbock, D. T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2639 · Cited by 935

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

Ranade, S. S., Qiu, Z., Woo, S., Hur, S. S., Murthy, S. E., Cahalan, S. M., Xu, J., Mathur, J., Bandell, M., Coste, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409233111 · Cited by 931

Smooth muscle cell phenotypic switching in atherosclerosis

Gomez, D. A., & Owens, G. K. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs115 · Cited by 889

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

Buckley, C. D., Gilroy, D. W., & Serhan, C. N. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.009 · Cited by 839

Epigenetic Control of Smooth Muscle Cell Differentiation and Phenotypic Switching in Vascular Development and Disease

Alexander, M. R., & Owens, G. K. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142315 · Cited by 796

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

Allahverdian, S., Chehroudi, A. C., McManus, B. M., Abraham, T., & Francis, G. A. (2014) · Circulation · doi:10.1161/circulationaha.113.005015 · Cited by 748

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

Parmar, K. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24787 · Cited by 710

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature

Dai, G., Mofrad, M. R. K., Natarajan, S., Zhang, Y., Vaughn, S., Blackman, B. R., Kamm, R. D., García‐Cardeña, G., & Gimbrone, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406073101 · Cited by 676

Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis

Tabas, I. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184783.04864.9f · Cited by 641

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

Spann, N. J., Garmire, L. X., McDonald, J. G., Myers, D. S., Milne, S. B., Shibata, N., Reichart, D. R., Fox, J. N., Shaked, I., Heudobler, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.054 · Cited by 630

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

Li, G., Mongillo, M., Chin, K., Harding, H. P., Ron, D., Marks, A. R., & Tabas, I. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200904060 · Cited by 619

Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function

Zhou, J., Li, Y.-S. J., & Chien, S. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303422 · Cited by 594

The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation

Hajra, L., Evans, A. I., Chen, M., Hyduk, S. J., Collins, T., & Cybulsky, M. I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9052 · Cited by 587

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

Feil, S., Fehrenbacher, B., Lukowski, R., Essmann, F., Schulze-Osthoff, K., Schaller, M., & Feil, R. (2014) · Circulation Research · doi:10.1161/circresaha.115.304634 · Cited by 578

Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading

Rong, J. X., Shapiro, M., Trogan, E., & Fisher, E. A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735526100 · Cited by 551

Inflammation and its Resolution as Determinants of Acute Coronary Syndromes

Libby, P., Tabas, I. A., Fredman, G., & Fisher, E. A. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302699 · Cited by 531

Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis

Schrijvers, D. M., De Meyer, G. R. Y., Kockx, M. M., Herman, A. G., & Martinet, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166517.18801.a7 · Cited by 509

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

Hochreiter-Hufford, A., & Ravichandran, K. S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008748 · Cited by 503

Vulnerable Plaque: The Pathology of Unstable Coronary Lesions

Virmani, R., BURKE, A. P., Kolodgie, F. D., & Farb, A. A. (2002) · Journal of Interventional Cardiology · doi:10.1111/j.1540-8183.2002.tb01087.x · Cited by 481

Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis

Gimbrone, M. A., & García‐Cardeña, G. (2012) · Cardiovascular Pathology · doi:10.1016/j.carpath.2012.06.006 · Cited by 448

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

Timmins, J. M., Özcan, L., Seimon, T. A., Li, G., Malagelada, C., Backs, J., Backs, T., Bassel‐Duby, R., Olson, E. N., Anderson, M. E., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38857 · Cited by 434

Increased Endoplasmic Reticulum Stress in Atherosclerotic Plaques Associated With Acute Coronary Syndrome

Myoishi, M., Hao, H., Minamino, T., Watanabe, K., Nishihira, K., Hatakeyama, K., Asada, Y., Okada, K.-I., Ishibashi‐Ueda, H., Gabbiani, G., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.682054 · Cited by 370

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

Fredman, G., Kamaly, N., Spolitu, S., Milton, J., Ghorpade, D. S., Chiasson, R., Kuriakose, G., Perretti, M., Farokhzad, O. C., & Tabas, I. A. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1065 · Cited by 362

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like Phenotype

Vengrenyuk, Y., Nishi, H., Long, X., Ouimet, M., Savji, N., Martinez, F. O., Cassella, C. P., Moore, K. J., Ramsey, S. A., Miano, J. M., et al. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.304029 · Cited by 358

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

Thorp, E. B., Li, G., Seimon, T. A., Kuriakose, G., Ron, D., & Tabas, I. A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.003 · Cited by 345

Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor–deficient mice

Kanters, E., Pasparakis, M., Gijbels, M. J., Vergouwe, M. N., Partouns-Hendriks, I., Fijneman, R. J. A., Clausen, B. E., Förster, I., Kockx, M. M., Rajewsky, K., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18580 · Cited by 340

Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation

Caplice, N. M., Bunch, T. J., Stalboerger, P. G., Wang, S., Simper, D., Miller, D. V., Russell, S. J., Litzow, M. R., & Edwards, W. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730743100 · Cited by 336

A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation

Sather, S., Kenyon, K. D., Lefkowitz, J. B., Liang, X., Varnum, B. C., Henson, P. M., & Graham, D. K. (2006) · Blood · doi:10.1182/blood-2006-05-021634 · Cited by 333

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

Jung, B., Obinata, H., Galvani, S., Mendelson, K., Ding, B., Skoura, A., Kinzel, B., Brinkmann, V., Rafii, S., Evans, T., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.07.015 · Cited by 322

Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis

Dunn, J., Qiu, H., Kim, S., Jjingo, D., Hoffman, R., Kim, C. W., Jang, I.-H., Son, D. J., Kim, D., Pan, C., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74792 · Cited by 308

Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes

Das, H., Kumar, A., Lin, Z., Patino, W. D., Hwang, P. M., Feinberg, M. W., Majumder, P. K., & Jain, M. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508235103 · Cited by 305

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

Thorp, E., Vaisar, T., Subramanian, M., Mautner, L., Blobel, C., & Tabas, I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.263020 · Cited by 298

Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling

Fessler, M. B., & Parks, J. S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100253 · Cited by 274

Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis

Kumar, S., Kim, C. W., Simmons, R. D., & Jo, H. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303425 · Cited by 274

Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor–deficient mice

Kanters, E., Pasparakis, M., Gijbels, M. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318580 · Cited by 272

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

Lin, J., Li, H., Yang, M. H., Ren, J., Huang, Z., Han, F., Huang, J., Ma, J., Zhang, D., Zhang, Z., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2012.12.012 · Cited by 266

Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-κB–Mediated Inflammation in Macrophages

Wang, Y., Wang, G. Z., Rabinovitch, P. S., & Tabas, I. A. (2013) · Circulation Research · doi:10.1161/circresaha.114.302153 · Cited by 264

ATP-Binding Cassette Transporters, Atherosclerosis, and Inflammation

Westerterp, M., Bochem, A. E., Yvan‐Charvet, L., Murphy, A. J., Wang, N., & Tall, A. R. (2014) · Circulation Research · doi:10.1161/circresaha.114.300738 · Cited by 261

Detection of histone modifications at specific gene loci in single cells in histological sections

Gomez, D., Shankman, L. S., Nguyen, A. T., & Owens, G. K. (2013) · Nature Methods · doi:10.1038/nmeth.2332 · Cited by 253

Conditional Deletion of Kruppel-Like Factor 4 Delays Downregulation of Smooth Muscle Cell Differentiation Markers but Accelerates Neointimal Formation Following Vascular Injury

Yoshida, T., Kaestner, K. H., & Owens, G. K. (2008) · Circulation Research · doi:10.1161/circresaha.108.176974 · Cited by 243

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

Zeng, L., Zampetaki, A., Margariti, A., Pepe, A. E., Alam, S., Martin, D., Xiao, Q., Wang, W., Jin, Z., COCKERILL, G. W., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903197106 · Cited by 234

Smooth Muscle Cells in Atherosclerosis Originate From the Local Vessel Wall and Not Circulating Progenitor Cells in ApoE Knockout Mice

Bentzon, J. F., Weile, C., Søndergaard, C. S., Hindkjær, J., Kassem, M. S., & Falk, E. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000247243.48542.9d · Cited by 233

The molecular mechanisms of the thrombotic complications of atherosclerosis

Libby, P. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01965.x · Cited by 226

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

Alexander, M. R., Moehle, C. W., Johnson, J. L., Yang, Z., Lee, J. K., Jackson, C. L., & Owens, G. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43713 · Cited by 223

Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events

Mullick, A. E., Soldau, K., Kiosses, W. B., Bell, T. A., Tobias, P. S., & Curtiss, L. K. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071096 · Cited by 221

Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice

Zhou, G., Hamik, A., Nayak, L. V., Tian, H., Shi, H., Lu, Y., Sharma, N., Liao, X., Hale, A. T., Boerboom, L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci66056 · Cited by 217

Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and Regression

Peled, M., & Fisher, E. A. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00579 · Cited by 212

Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis

Civelek, M., Manduchi, E., Riley, R., Stoeckert, C. J., & Davies, P. F. (2009) · Circulation Research · doi:10.1161/circresaha.109.203711 · Cited by 208

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B 4 synthesis by inhibiting a calcium-activated kinase pathway

Fredman, G., Özcan, L., Spolitu, S., Hellmann, J. L., Spite, M. R., Backs, J., & Tabas, I. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410851111 · Cited by 197

Hemodynamic Disturbed Flow Induces Differential DNA Methylation of Endothelial Kruppel-Like Factor 4 Promoter In Vitro and In Vivo

Jiang, Y., Jiménez, J. M., Ou, K., McCormick, M. E., Zhang, L.-D., & Davies, P. F. (2014) · Circulation Research · doi:10.1161/circresaha.115.303883 · Cited by 196

Hemizygous Deficiency of Kruppel-Like Factor 2 Augments Experimental Atherosclerosis

Atkins, G. B., Wang, Y., Mahabeleshwar, G. H., Shi, H., Gao, H., Kawanami, D., Natesan, V., Lin, Z., Simon, D. I., & Jain, M. K. (2008) · Circulation Research · doi:10.1161/circresaha.108.184663 · Cited by 180

Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling

Baeyens, N., Mulligan‐Kehoe, M. J., Corti, F., Simon, D., Ross, T. D., Rhodes, J., Wang, T. Z., Mejean, C. O., Simons, M., Humphrey, J. D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413725111 · Cited by 172

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells

Villarreal, G., Zhang, Y., Larman, H. B., Gracia‐Sancho, J., Koo, A., & García‐Cardeña, G. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.002 · Cited by 170

Erk5 Activation Elicits a Vasoprotective Endothelial Phenotype via Induction of Krüppel-like Factor 4 (KLF4)

Ohnesorge, N., Viemann, D., Schmidt, N., Czymai, T., Spiering, D., Schmolke, M., Ludwig, S., Roth, J., Goebeler, M., & Schmidt, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.103127 · Cited by 152

Annexin A1 Counteracts Chemokine-Induced Arterial Myeloid Cell Recruitment

Drechsler, M., de Jong, R., Rossaint, J., Viola, J. R., Leoni, G., Wang, J. M., Grommes, J., Hinkel, R., Kupatt, C., Weber, C., et al. (2015) · Circulation Research · doi:10.1161/circresaha.116.305825 · Cited by 150

Endothelial cell morphology in areas of in vivo Evans blue uptake in the aorta of young pigs. II. Ultrastructure of the intima in areas of differing permeability to proteins.

Gerrity, R. G., Richardson, M., Somer, J. B., Bell, F. P., & Schwartz, C. J. (1977) · PubMed Central · Cited by 141

A G/C Element Mediates Repression of the SM22α Promoter Within Phenotypically Modulated Smooth Muscle Cells in Experimental Atherosclerosis

Wamhoff, B. R., Hoofnagle, M. H., Burns, A., Sinha, S., McDonald, O. G., & Owens, G. K. (2004) · Circulation Research · doi:10.1161/01.res.0000147961.09840.fb · Cited by 137

Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback That Sustains Endothelial Inflammation

Feaver, R. E., Gelfand, B. D., Wang, C., Schwartz, M. A., & Blackman, B. R. (2010) · Circulation Research · doi:10.1161/circresaha.109.216283 · Cited by 136

Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells

Koo, A., Dewey, C. F., & García‐Cardeña, G. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00187.2012 · Cited by 136

Relative Reduction of Endothelial Nitric-Oxide Synthase Expression and Transcription in Atherosclerosis-Prone Regions of the Mouse Aorta and in an in Vitro Model of Disturbed Flow

Won, D., Zhu, S.-N., Chen, M., Teichert, A.-M., Fish, J. E., Matouk, C. C., Bonert, M., Ojha, M., Marsden, P. A., & Cybulsky, M. I. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060860 · Cited by 134

Bone Marrow–Derived Cells Contribute to Vascular Inflammation but Do Not Differentiate Into Smooth Muscle Cell Lineages

Iwata, H., Manabe, I., Fujiu, K., Yamamoto, T., Takeda, N., Eguchi, K., Furuya, A., Kuro‐o, M., Sata, M., & Nagai, R. (2010) · Circulation · doi:10.1161/circulationaha.110.965202 · Cited by 133

Mechanosensitive microRNAs—role in endothelial responses to shear stress and redox state

Marin, T., Gongol, B., Chen, Z. B., Woo, B. J., Subramaniam, S., Chien, S., & Shyy, J. Y.-J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.034 · Cited by 124

Collagenases and cracks in the plaque

Libby, P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67526 · Cited by 124

Macrophages Create an Acidic Extracellular Hydrolytic Compartment to Digest Aggregated Lipoproteins

Haka, A. S., Grosheva, I., Chiang, E. N., Buxbaum, A. R., Baird, B. A., Pierini, L. M., & Maxfield, F. R. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-07-0559 · Cited by 120

Impaired glycocalyx barrier properties contribute to enhanced intimal low-density lipoprotein accumulation at the carotid artery bifurcation in mice

van den Berg, B. M., Spaan, J. A. E., & Vink, H. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0590-6 · Cited by 120

Novel Mechanisms of Endothelial Mechanotransduction

Abe, J., & Berk, B. C. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303428 · Cited by 108

The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis

Thorp, E., Subramanian, M., & Tabas, I. (2011) · European Journal of Immunology · doi:10.1002/eji.201141719 · Cited by 107

Statin-induced Kruppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses

Bu, D.-X., Tarrio, M. L., Grabie, N., Zhang, Y., Yamazaki, H., Stavrakis, G., Maganto-García, E., Pepper-Cunningham, Z. A., Jarolı́m, P., Aikawa, M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41384 · Cited by 105

Myeloid-Specific Krüppel-Like Factor 2 Inactivation Increases Macrophage and Neutrophil Adhesion and Promotes Atherosclerosis

Lingrel, J. B., Pilcher-Roberts, R., Basford, J. E., Manoharan, P., Neumann, J. C., Konaniah, E. S., Srinivasan, R., Bogdanov, V. Y., & Hui, D. Y. (2012) · Circulation Research · doi:10.1161/circresaha.112.267310 · Cited by 92

Myeloid Krüppel-Like Factor 4 Deficiency Augments Atherogenesis in ApoE −/− Mice—Brief Report

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Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1

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