Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities
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A number of widespread and devastating chronic diseases, including atherosclerosis, type 2 diabetes, and Alzheimer’s disease, have a pathophysiologically important inflammatory component. In these diseases, the precise identity of the inflammatory stimulus is often unknown and, if known, is difficult to remove. Thus, there is interest in therapeutically targeting the inflammatory response. Although there has been success with anti-inflammatory therapy in chronic diseases triggered by primary inflammation dysregulation or autoimmunity, there are considerable limitations. In particular, the inflammatory response is critical for survival. As a result, redundancy, compensatory pathways, and necessity narrow the risk:benefit ratio of anti-inflammatory drugs. However, new advances in understanding inflammatory signaling and its links to resolution pathways, together with new drug development, offer promise in this area of translational biomedical research.
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Many chronic inflammatory diseases, including advanced atherosclerosis, are characterized by an imbalance between pro-resolving and pro-inflammatory mediators such as leukotrienes, leading to defective resolution, tissue injury, and DAMP-mediated inflammation.
“Many chronic inflammatory diseases, including advanced atherosclerosis, are characterized by an imbalance between pro-resolving and pro-inflammatory mediators, such as leukotrienes, leading to defective resolution of inflammation, tissue injury and damage-associated molecular pattern (DAMP)-mediated inflammation31–33.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [33]
SPMs suppress inflammation but, unlike anti-inflammatory drugs, promote both repair and continued pathogen clearance.
“From a translational perspective, SPMs suppress inflammation but, unlike anti-inflammatory drugs, these pro-resolving mediators promote both repair and continued pathogen clearance33,213–215.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [33]
Anti-IL-1β antibody therapy was associated with a small but significant increase in certain fatal infections, explainable by the host defence-compromising potential of pure anti-inflammatory therapy.
“Unfortunately, the anti-IL-1β antibody therapy was associated with a small but significant increase in certain fatal infections212, which can be explained by the host defence-compromising potential of a pure anti-inflammatory therapy33.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [33]
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- Authors
- Tabas, I., & Glass, C. K.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of California San Diego (US)
- Corresponding author
- Tabas, Ira
- Glass, Christopher K.
- Venue
- Science
- Published
- 2013-01-11
- Volume
- 339
- Issue
- 6116
- Pages
- 166-172
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3608517
- OpenAlex
- W2020466729
- Cited by
- 1,093
- References
- 74
- Citations by year
- 2026: 50 · 2025: 57 · 2024: 60 · 2023: 74 · 2022: 82 · 2021: 75 · 2020: 97 · 2019: 85 · 2018: 104 · 2017: 91 · 2016: 77 · 2015: 95 · 2014: 85 · 2013: 59 · 2012: 1
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL054591, R01HL106019, HC088093, R01HL057560, P01HL087123, R01HL075662, R01HL107497)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 074868, DK091183, P01DK074868, R01DK091183)
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- anti-inflammatory therapy, chronic disease, inflammation, atherosclerosis, type 2 diabetes, Alzheimer's disease, inflammatory signaling, inflammation resolution, compensatory pathways, drug development
- MeSH terms
- Animals, Anti-Inflammatory Agents, Autoimmune Diseases, Cardiovascular Diseases, Chronic Disease, Diabetes Mellitus, Type 2, Humans, Inflammation, Neurodegenerative Diseases
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