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Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice.
Open accessAbstract
A single intracheal dose of liposome-encapsuled dichloro-methylene-diphosphonate resulted in the elimination of alveolar macrophages (AM) from the lung, creating a model to study the in vivo role of AM in the pulmonary immune response. Using intratracheally administered trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH), the kinetics of the response, the location and number of TNP-specific antibody-forming cells, and the different Ig classes of the antibodies produced were studied in AM-depleted animals. The results show that AM elimination has a dramatic effect on the pulmonary immune responses against TNP-KLH. An increase in APC in lung-associated lymph nodes and a prolongation of the response is found, as well as an introduction of APC in lung tissue. In both experimental groups, the majority of the TNP-specific antibodies produced was IgG, followed by IgA and IgE, while very few IgM antibodies could be detected. We conclude from these results that AM are likely to play a role in controlling the pulmonary immune response in a suppressive way, thereby limiting the possible damage caused by severe immune responses in lung tissue.
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Self-citation
Metadata
- Authors
- Thepen, T., Van Rooijen, N., & Kraal, G.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-08-01
- Volume
- 170
- Issue
- 2
- Pages
- 499-509
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1997653917
- Cited by
- 422
- References
- 0
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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