The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Open accessAbstract
A human receptor that is selective for the CXC chemokines IP10 and Mig was cloned and characterized. The receptor cDNA has an open reading frame of 1104-bp encoding a protein of 368 amino acids with a molecular mass of 40,659 dalton. The sequence includes seven putative transmembrane segments characteristic of G-protein coupled receptors. It shares 40.9 and 40.3% identical amino acids with the two IL-8 receptors, and 34.2-36.9% identity with the five known CC chemokine receptors. The IP10/Mig receptor is highly expressed in IL-2-activated T lymphocytes, but is not detectable in resting T lymphocytes. B lymphocytes, monocytes and granulocytes. It mediates Ca2+ mobilization and chemotaxis in response to IP10 and Mig, but does not recognize the CXC-chemokines IL-8, GRO alpha, NAP-2, GCP-2. ENA78, PF4, the CC-chemokines MCP-1, MCP-2, MCP-3, MCP-4, MIP-1 alpha, MIP-1 beta. RANTES, 1309, eotaxin, nor lymphotactin. The exclusive expression in activated T-lymphocytes is of high interest since the receptors for chemokines which have been shown so far to attract lymphocytes, e.g., MCP-1, MCP-2, MCP-3, MIP-1 alpha, MIP-1 beta, and RANTES, are also found in monocytes and granulocytes. The present observations suggest that the IP10/Mig receptor is involved in the selective recruitment of effector T cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
G-protein-coupled receptor kinases
Palczewskl, K., & Benovic, J. L. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90157-q · Cited by 218
Cited by
Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer
Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., Makrigiannakis, A., Gray, H., Schlienger, K., Liebman, M. N., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020177 · Cited by 3,397
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817
Self-citationCXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation - a target for novel cancer therapy
Tokunaga, R., Zhang, W., Naseem, M., Puccini, A., Berger, M. D., Soni, S., McSkane, M., Baba, H., & Lenz, H.-J. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.11.007 · Cited by 1,627
Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B., & Mackay, C. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1422 · Cited by 1,359
Self-citationDufour, J. H., Dziejman, M., Liu, M. T., Leung, J. H., Lane, T. E., & Luster, A. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3195 · Cited by 1,075
Cole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.2009 · Cited by 870
Self-citationMicroglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., et al. (2023) · Nature · doi:10.1038/s41586-023-05788-0 · Cited by 609
Engelhardt, E., Toksoy, A., Goebeler, M., Debus, S., Bröcker, E.-B., & Gillitzer, R. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65699-4 · Cited by 435
Yoshie, O., Fujisawa, R., Nakayama, T., Harasawa, H., Tago, H., Izawa, D., Hieshima, K., Tatsumi, Y., Matsushima, K., Hasegawa, H., et al. (2002) · Blood · doi:10.1182/blood.v99.5.1505 · Cited by 326
Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System
Strehl, C., Ehlers, L., Gaber, T., & Buttgereit, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01744 · Cited by 308
Cytokines and immunity to viral infections
Ramshaw, I. A., Ramsay, A. J., Karupiah, G., Rolph, M. S., Mahalingam, S., & Ruby, J. C. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01011.x · Cited by 257
(1999) · PubMed · Cited by 207
Chemokines as mediators of neovascularization
Keeley, E. C., Mehrad, B., & Strieter, R. M. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.162925 · Cited by 192
Addison, C. L., Arenberg, D. A., Morris, S. B., Xue, Y.-Y., Burdick, M. D., Mulligan, M. S., Iannettoni, M. D., & Strieter, R. M. (2000) · Human Gene Therapy · doi:10.1089/10430340050015996 · Cited by 136
Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms
Lu, H.-J., & Gao, Y.-J. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-00961-3 · Cited by 118
Role of CXCR3/CXCL10 Axis in Immune Cell Recruitment into the Small Intestine in Celiac Disease
Bondar, C., Araya, R. E., Guzman, L., Rua, E. C., Chopita, N., & Chirdo, F. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089068 · Cited by 85
Rotondi, M., Rosati, A., Buonamano, A., Lasagni, L., Lazzeri, E., Pradella, F., Fossombroni, V., Cirami, C., Liotta, F., La Villa, G., et al. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00525.x · Cited by 92
Rosenblum, J. M., Shimoda, N., Schenk, A. D., Zhang, H., Kish, D. D., Keslar, K., Farber, J. M., & Fairchild, R. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903831 · Cited by 80
Montes de Oca, P., Macotela, Y., Nava, G., López-Barrera, F., de la Escalera, G. M., & Clapp, C. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700256 · Cited by 71
Vlkolinský, R., Siggins, G. R., Campbell, I. L., & Krucker, T. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.011 · Cited by 57
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts
Zindl, C. L., Witte, S. J., Laufer, V. A., Gao, M., Yue, Z., Janowski, K. M., Cai, B., Frey, B. F., Silberger, D. J., Harbour, S. N., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.02.003 · Cited by 49
Sintov, E., Nikolskiy, I., Barrera, V., Hyoje-Ryu Kenty, J., Atkin, A. S., Gerace, D., Ho Sui, S. J., Boulanger, K., & Melton, D. A. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.08.002 · Cited by 45
Joachimbauer, A., Perez-Shibayama, C., Payne, E., Hanka, I., Stadler, R., Papadopoulou, I., Rickli, H., Mäder, M. T., Borst, O., Zdanyte, M., et al. (2026) · medRxiv · doi:10.64898/2026.04.10.26350598 · Cited by 1
Metadata
- Authors
- Loetscher, M., Gerber, B., Loetscher, P., Jones, S. A., Piali, L., Clark-Lewis, I., Baggiolini, M., & Moser, B.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-09-01
- Volume
- 184
- Issue
- 3
- Pages
- 963-969
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1998605540
- Cited by
- 1,193
- References
- 1
- FWCI
- 24.27
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
