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Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice
Open accessAbstract
We generated vascular cell adhesion molecule (VCAM)-1 “knock-in” mice and Cre recombinase transgenic mice to delete the VCAM-1 gene (vcam-1) in whole mice, thereby overcoming the embryonic lethality seen with conventional vcam-1–deficient mice. vcam-1 knock-in mice expressed normal levels of VCAM-1 but showed loss of VCAM-1 on endothelial and hematopoietic cells when interbred with a “TIE2Cre” transgene. Analysis of peripheral blood from conditional vcam-1–deficient mice revealed mild leukocytosis, including elevated immature B cell numbers. Conversely, the bone marrow (BM) had reduced immature B cell numbers, but normal numbers of pro-B cells. vcam-1–deficient mice also had reduced mature IgD+ B and T cells in BM and a greatly reduced capacity to support short-term migration of transferred B cells, CD4+ T cells, CD8+ T cells, and preactivated CD4+ T cells to the BM. Thus, we report an until now unappreciated dominant role for VCAM-1 in lymphocyte homing to BM.
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Metadata
- Authors
- Koni, P. A., Joshi, S. K., Temann, U.-A., Olson, D., Burkly, L., & Flavell, R. A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-03-19
- Volume
- 193
- Issue
- 6
- Pages
- 741-754
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2157288494
- Cited by
- 482
- References
- 0
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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