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Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes
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We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE/presenilin 1 (PS1)ΔE9 transgenic model of Aβ amyloidosis. We now show that in an independent, aggressive APPSWE/PS1L166P (APPPS1-21) mouse model of Aβ amyloidosis, an ABX-perturbed gut microbiome is associated with a reduction in Aβ pathology and alterations in microglial morphology, thus establishing the generality of the phenomenon. Most importantly, these latter alterations occur only in brains of male mice, not in the brains of female mice. Furthermore, ABX treatment lead to alterations in levels of selected microglial expressed transcripts indicative of the “M0” homeostatic state in male but not in female mice. Finally, we found that transplants of fecal microbiota from age-matched APPPS1-21 male mice into ABX-treated APPPS1-21 male restores the gut microbiome and partially restores Aβ pathology and microglial morphology, thus demonstrating a causal role of the microbiome in the modulation of Aβ amyloidosis and microglial physiology in mouse models of Aβ amyloidosis.
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“Moreover, sex-specific differences have been noted, with female AD mouse models showing more pronounced microbiota-driven amyloid deposition and microglial activation compared to males140.”
From Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions (2025) · cites this paper as [140]
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“and transplants of fecal microbiota of genotype- and age-matched male mice partially restored Aβ pathology and microglial morphology9.”
From Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice (2021) · cites this paper as [9]
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“These data are consistent with the association of microbiome perturbations induced by antibiotics with neuropathological measures in male mice overexpressing hAPP with the Swedish mutation and presenilin 1, and the ability of transplants of fecal microbiota of genotype- and age-matched male mice to partially restore neuropathology9.”
From Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice (2021) · cites this paper as [9]
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“Importantly, the AD pathologies in antibiotic-treated male mice were partially restored after 3-week FMT from age-matched male APP/PS1-21 mice.197”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [197]
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DADA2: High–resolution sample inference from Illumina amplicon data
Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698
MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform
Katoh, K. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf436 · Cited by 17,027
FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments
Price, M. N., Dehal, P. S., & Arkin, A. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009490 · Cited by 14,894
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
TREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Flagged first, then by citations
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The gut microbiome in neurological disorders
Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336
Wang, X., Sun, G., Feng, T., Zhang, J., Huang, X., Wang, T., Xie, Z., Chu, X., Yang, J., Wang, H., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0216-x · Cited by 1,144
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Esfehani, R. J., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 586
Chen, C., Liao, J., Xia, Y., Liu, X., Jones, R., Haran, J., McCormick, B., Sampson, T. R., Alam, A., & Ye, K. (2022) · Gut · doi:10.1136/gutjnl-2021-326269 · Cited by 491
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
Sampson, T. R., Challis, C., Jain, N., Moiseyenko, A., Ladinsky, M. S., Shastri, G. G., Thron, T., Needham, B. D., Horvath, I., Debelius, J. W., et al. (2020) · eLife · doi:10.7554/elife.53111 · Cited by 439
Peripheral and central immune system crosstalk in Alzheimer disease — a research prospectus
Bettcher, B. M., Tansey, M. G., Dorothée, G., & Heneka, M. T. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00549-x · Cited by 427
Fecal Microbiota Transplantation in Neurological Disorders
Vendrik, K. E. W., Ooijevaar, R. E., de Jong, P. R. C., Laman, J. D., van Oosten, B. W., van Hilten, J. J., Ducarmon, Q. R., Keller, J. J., Kuijper, E. J., & Contarino, M. F. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00098 · Cited by 413
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Rajan, W. D., Theys, T., Mancuso, R., Tito, R. Y., Kouser, L., Callaerts-Vegh, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.026 · Cited by 368
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Colombo, A. V., Sadler, R. K., Llovera, G., Singh, V., Roth, S., Heindl, S., Sebastian Monasor, L., Verhoeven, A., Peters, F., Parhizkar, S., et al. (2021) · eLife · doi:10.7554/elife.59826 · Cited by 354
The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347
The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease
Bairamian, D., Sha, S., Rolhion, N., Sokol, H., Dorothée, G., Lemere, C. A., & Krantic, S. M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00522-2 · Cited by 326
Microglia, Lifestyle Stress, and Neurodegeneration
Madore, C., Yin, Z., Leibowitz, J. A., & Butovsky, O. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.003 · Cited by 313
Self-citationThe gut microbiome in Alzheimer’s disease: what we know and what remains to be explored
Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278
Self-citationSeo, D.-O., O’Donnell, D., Jain, N., Ulrich, J. D., Herz, J., Li, Y., Lemieux, M., Cheng, J., Hu, H., Serrano, J. R., et al. (2023) · Science · doi:10.1126/science.add1236 · Cited by 254
Self-citationCurrent understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies
Seo, D.-O., & Holtzman, D. M. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01146-2 · Cited by 259
The Microbiome as a Modifier of Neurodegenerative Disease Risk
Fang, P., Kazmi, S. A., Jameson, K. G., & Hsiao, E. Y. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.06.008 · Cited by 226
The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment
Varesi, A., Pierella, E., Romeo, M., Piccini, G. B., Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., et al. (2022) · Nutrients · doi:10.3390/nu14030668 · Cited by 225
Xiao, J., Katsumata, N., Bernier, F., Ohno, K., Yamauchi, Y., Odamaki, T., Yoshikawa, K., Ito, K., & Kaneko, T. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200488 · Cited by 216
Chen, C., Ahn, E. H., Kang, S. S., Liu, X., Alam, A., & Ye, K. (2020) · Science Advances · doi:10.1126/sciadv.aba0466 · Cited by 205
You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan
Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200
Probiotics for Alzheimer’s Disease: A Systematic Review
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The microbiome-gut-brain axis in acute and chronic brain diseases
Benakis, C., Martin‐Gallausiaux, C., Trezzi, J., Melton, P., Liesz, A., & Wilmes, P. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.11.009 · Cited by 189
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Lukens, J. R., & Eyo, U. B. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-023056 · Cited by 171
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Zhang, T., Gao, G., Kwok, L., & Sun, Z. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2271613 · Cited by 162
Chen, Y., Fang, L., Chen, S., Zhou, H., Fan, Y., Li, L., Li, J., Xu, J., Chen, Y., Ma, Y., et al. (2020) · BioMed Research International · doi:10.1155/2020/8456596 · Cited by 153
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Lynch, M. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.868448 · Cited by 146
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Kim, M., & Benayoun, B. A. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.07.004 · Cited by 144
Cox, L. M., Schafer, M. J., Sohn, J., Vincentini, J., Weiner, H. L., Ginsberg, S. D., & Blaser, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-54187-x · Cited by 134
The endotoxin hypothesis of Alzheimer’s disease
Brown, G. C., & Heneka, M. T. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00722-y · Cited by 148
The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer’s Disease
Narengaowa, Kong, W., Lan, F., Awan, M. U. F., Qing, H., & Ni, J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.633735 · Cited by 134
Honarpisheh, P., Reynolds, C. R., Conesa, M. P. B., Moruno-Manchon, J. F., Putluri, N., Bhattacharjee, M. B., Urayama, A., McCullough, L. D., & Ganesh, B. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051711 · Cited by 129
Microglia in Alzheimer’s Disease in the Context of Tau Pathology
Perea, J. R., Bolós, M., & Ávila, J. (2020) · Biomolecules · doi:10.3390/biom10101439 · Cited by 134
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Ennerfelt, H. E., & Lukens, J. R. (2020) · Immunological Reviews · doi:10.1111/imr.12896 · Cited by 124
Gut microbiome-mediated regulation of neuroinflammation
Bostick, J. W., Schonhoff, A. M., & Mazmanian, S. K. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102177 · Cited by 120
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia
Dodiya, H. B., Lutz, H. L., Weigle, I. Q., Patel, P., Michalkiewicz, J., Roman-Santiago, C. J., Zhang, C. M., Liang, Y., Srinath, A., Zhang, X., et al. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20200895 · Cited by 120
Self-citationHe, X., Li, L., Xian, W., Li, M., Zhang, L., Xu, J., Pei, Z., Zheng, H., & Hu, X. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02199-8 · Cited by 116
Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer’s disease
Kaur, H., Nagamoto‐Combs, K., Golovko, S. A., Golovko, M. Y., Klug, M. G., & Combs, C. K. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.009 · Cited by 115
Microbiota-brain interactions: Moving toward mechanisms in model organisms
Nagpal, J. K., & Cryan, J. F. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.036 · Cited by 110
Boundaries and integration between microbiota, the nervous system, and immunity
Macpherson, A. J., Pachnis, V., & Prinz, M. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.011 · Cited by 118
Cavedo, E., Chiesa, P. A., Houot, M., Ferretti, M. T., Grothe, M. J., Teipel, S. J., Lista, S., Habert, M., Potier, M., Dubois, B., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.05.014 · Cited by 111
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Xu, H., Huang, H., Zhou, Y., Zhao, H., Xu, J., Shou, D., Liu, Y., Zhou, Y., & Nie, Y. (2021) · Gastroenterology Research and Practice · doi:10.1155/2021/6699268 · Cited by 100
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Brain modulation by the gut microbiota: From disease to therapy
Mitra, S., Dash, R., Nishan, A. A., Habiba, S. U., & Moon, I. S. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2022.12.001 · Cited by 91
Zhai, X., Chen, K., Yang, H., Li, B., Zhou, T., Wang, H., Zhou, H., Chen, S., Zhou, X., Wei, X., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01022-z · Cited by 89
Matheson, J.-A. T., & Holsinger, R. M. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021001 · Cited by 96
Ren, F., Wei, J., Chen, Q., Hu, M., Yu, L., Mi, J., Zhou, X., Qin, D., Wu, J., & Wu, A. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.030 · Cited by 97
The gut microbiome and Alzheimer’s disease: Complex and bidirectional interactions
Tarawneh, R. M., & Penhos, E. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104814 · Cited by 92
Chen, Y., Li, Y., Fan, Y., Chen, S., Chen, L., Chen, Y., & Chen, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2302310 · Cited by 92
Zhu, G., Zhao, J., Wang, G., & Chen, W. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00652 · Cited by 84
Dodiya, H. B., Frith, M., Sidebottom, A. M., Cao, Y., Koval, J., Chang, E. B., & Sisodia, S. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-64797-5 · Cited by 86
Self-citationZhang, Y., Shen, Y., Liufu, N., Liu, L., Li, W., Shi, Z., Zheng, H., Mei, X., Chen, C.-Y., Jiang, Z., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02216-7 · Cited by 83
Holmes, A., Finger, C. E., Morales‐Scheihing, D., Lee, J., & McCullough, L. D. (2020) · Translational research · doi:10.1016/j.trsl.2020.07.012 · Cited by 88
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Xie, Y., Zou, X., Han, J., Zhang, Z., Feng, Z., Ouyang, Q., Hua, S., Liu, Z., Li, C., Cai, Y., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114081 · Cited by 80
Li, Y., Shao, L., Mou, Y., Zhang, Y., & Ping, Y. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1957407 · Cited by 84
Ullah, R., Park, T. J., Huang, X., & Kim, M. O. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101451 · Cited by 78
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How microbiota shape microglial phenotypes and epigenetics
Erny, D., & Prinz, M. (2020) · Glia · doi:10.1002/glia.23822 · Cited by 80
Kundu, P., Torres, E. R. S., Stagaman, K., Kasschau, K., Okhovat, M., Holden, S., Ward, S., Nevonen, K. A., Davis, B. A., Saito, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83851-4 · Cited by 75
Hole, K. L., & Williams, R. J. (2020) · Brain Plasticity · doi:10.3233/bpl-200098 · Cited by 81
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Zhao, H., Zhou, X., Song, Y., Zhao, W., Sun, Z., Zhu, J., & Yu, Y. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01683-0 · Cited by 85
Wasén, C., Beauchamp, L. C., Vincentini, J., Li, S., LeServe, D. S., Gauthier, C. D., Lopes, J. R., Moreira, T. G., Ekwudo, M. N., Yin, Z., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47683-w · Cited by 77
Self-citationCuervo-Zanatta, D., Syeda, T., Sánchez-Valle, V., Irene-Fierro, M., Torres‐Aguilar, P. C., Torres-Ramos, M., Shibayama-Salas, M., Silva-Olivares, A., Noriega, L. G., Torres, N., et al. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01268-7 · Cited by 76
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Zhang, G., Zhang, Y.-R., Shen, Y., Wang, Y., Zhao, M. L., & Sun, L. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201369 · Cited by 71
Liang, Y., Liu, C., Cheng, M., Geng, L., Li, J., Du, W., Song, M., Chen, N., Yeleen, T. A. N., Li, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14057 · Cited by 73
Bosch, M. E., Dodiya, H. B., Michalkiewicz, J., Lee, C., Shaik, S. M., Weigle, I. Q., Zhang, C., Osborn, J., Nambiar, A., Patel, P., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00700-w · Cited by 70
Self-citationModulation of Glial Function in Health, Aging, and Neurodegenerative Disease
Hanslik, K. L., Marino, K. M., & Ulland, T. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.718324 · Cited by 69
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Singh, J., Vanlallawmzuali, Singh, A. K., Biswal, S., Zomuansangi, R., Lalbiaktluangi, C., Singh, B. P., Singh, P. K., Vellingiri, B., Iyer, M., et al. (2024) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2024.104068 · Cited by 71
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Weng, J. M., Parikh, I. J., Naqib, A. D., York, J. M., Green, S. J., Estus, S., & LaDu, M. J. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0352-2 · Cited by 65
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Ge, T., Yao, X., Zhao, H., Yang, W., Zou, X., Peng, F., Li, B., & Cui, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105909 · Cited by 62
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Ghezzi, L., Cantoni, C., Rotondo, E., & Galimberti, D. (2022) · Biomedicines · doi:10.3390/biomedicines10071486 · Cited by 61
Dunham, S. J. B., McNair, K., Adams, E. D., Avelar‐Barragan, J., Forner, S., Mapstone, M. E., & Whiteson, K. (2022) · mBio · doi:10.1128/mbio.01794-22 · Cited by 59
Cuervo-Zanatta, D., Garcı́a-Mena, J., & Perez‐Cruz, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201367 · Cited by 62
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Basak, J. M., Ferreiro, A., Cohen, L. S., Sheehan, P. W., Nadarajah, C. J., Kanan, M. F., Sukhum, K. V., Dantas, G., & Musiek, E. S. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105292 · Cited by 46
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Qu, L., Li, Y., Liu, F., Fang, Y., He, J., Ma, J., Xu, T., Wang, L., Lei, P., Dong, H., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0823-2 · Cited by 46
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Metadata
- Authors
- Dodiya, H. B., Kuntz, T., Shaik, S. M., Baufeld, C., Leibowitz, J., Zhang, X., Gottel, N., Zhang, X., Butovsky, O., Gilbert, J. A., & Sisodia, S. S.
- Affiliations
- University of Chicago (US)
- Brigham and Women's Hospital (US)
- Scripps Institution of Oceanography (US)
- Corresponding author
- Sisodia, Sangram S.
- ORCID
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2019-05-16
- Volume
- 216
- Issue
- 7
- Pages
- 1542-1560
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC6605759
- OpenAlex
- W2945327298
- Cited by
- 288
- References
- 71
- Citations by year
- 2026: 19 · 2025: 50 · 2024: 54 · 2023: 45 · 2022: 40 · 2021: 39 · 2020: 33 · 2019: 7
- FWCI
- 20.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-sa)
- Funders
- Cure Alzheimer’s Fund
- Open Philanthropy Project and Good Ventures Foundation
- Edward H. Levi Fund
- National Institute of Neurological Disorders and Stroke (1R01NS088137, R21NS104609, R21NS101673)
- National Institute on Aging (R01AG051812, R01AG054672)
- National Multiple Sclerosis Society
- Amyotrophic Lateral Sclerosis Association
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- gut microbiota, Alzheimer's disease, microglia, sex differences, antibiotic perturbation, fecal microbiota transplantation, astrocyte activation, neuroinflammation
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Anti-Bacterial Agents, Brain Diseases, Disease Models, Animal, Female, Male, Sex Factors, Amyloid beta-Protein Precursor, Microglia, Amyloid Neuropathies, Mice, Plaque, Amyloid
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