Cited by 84Gut microbiota and healthProbiotics and Fermented FoodsAlzheimer's disease research and treatments

Bifidobacterium breve HNXY26M4 Attenuates Cognitive Deficits and Neuroinflammation by Regulating the Gut–Brain Axis in APP/PS1 Mice

Zhu, Guangsu, Zhao, Jianxin, Wang, Gang, Chen, Wei·2023·Journal of Agricultural and Food Chemistry

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease, pathological markers of which are amyloid plaques and neurofibrillary tangles. As a key node of gut–brain axis, gut microbiota is increasingly associated with changes in cognitive behaviors and brain function. Psychobiotics are known to benefit patients with neurodegenerative diseases by the production and deliberation of neuroactive substances. However, psychobiotics are strain-specific probiotics, and their neuroprotective effects on the brain and modulation effects on the gut microbiome are not generalizable. In this study, we investigated the effects of Bifidobacterium breve HNXY26M4 in APP/PS1 mice. By assessing the alterations associated with brain function, we found that B. breve HNXY26M4 attenuated cognitive deficits and suppressed neuroinflammation and synaptic dysfunction in APP/PS1 mice. Moreover, by determining the modulation effects of B. breve HNXY26M4 on gut homeostasis, we identified that B. breve HNXY26M4 supplementation restored the composition of gut microbiota and short-chain fatty acids, as well as enhanced the function of the intestinal barrier. These findings indicate that microbiome-derived acetate and butyrate modulated by B. breve HNXY26M4 administration may be transported to the brain through the blood–brain barrier, and thus confer neuroprotective effects against AD-associated brain deficits and inflammation via the gut–brain axis.

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Crossref · 10.1021/acs.jafc.3c00652

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  • Probiotic and prebiotic interventions aimed at elevating SCFA levels have neuroprotective effects in AD mouse models by inhibiting glial activation and Aβ deposition.

    “Moreover, probiotic and prebiotic interventions aimed at elevating SCFA levels have demonstrated neuroprotective effects in AD mouse models by inhibiting glial activation and Aβ deposition.301–306”

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Authors
Zhu, G., Zhao, J., Wang, G., & Chen, W.
Affiliations
Jiangnan University (CN)
Corresponding author
  • Zhu, Guangsu
  • Wang, Gang
Venue
Journal of Agricultural and Food Chemistry
Published
2023-03-08
Volume
71
Issue
11
Pages
4646-4655
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W4323537878
Cited by
84
References
40
Citations by year
2026: 21 · 2025: 28 · 2024: 25 · 2023: 10
FWCI
7.47
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Central University Basic Research Fund of China (JUSRP22006, JUSRP51501)
  • National Natural Science Foundation of China (31820103010, 31972052, 32021005)
  • Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, gut-brain axis, cognitive impairment, neuroinflammation, synaptic dysfunction, APP/PS1 mice, gut microbiota, short-chain fatty acids, acetate, butyrate, intestinal barrier, blood-brain barrier, psychobiotics, neuroprotection
MeSH terms
Bifidobacterium breve, Brain-Gut Axis, Neuroinflammatory Diseases, Alzheimer Disease, Animals, Cognition, Mice, Transgenic, Amyloid beta-Protein Precursor, Neuroprotective Agents, Neurodegenerative Diseases, Mice, Cognitive Dysfunction

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