Bifidobacterium breve HNXY26M4 Attenuates Cognitive Deficits and Neuroinflammation by Regulating the Gut–Brain Axis in APP/PS1 Mice
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease, pathological markers of which are amyloid plaques and neurofibrillary tangles. As a key node of gut–brain axis, gut microbiota is increasingly associated with changes in cognitive behaviors and brain function. Psychobiotics are known to benefit patients with neurodegenerative diseases by the production and deliberation of neuroactive substances. However, psychobiotics are strain-specific probiotics, and their neuroprotective effects on the brain and modulation effects on the gut microbiome are not generalizable. In this study, we investigated the effects of Bifidobacterium breve HNXY26M4 in APP/PS1 mice. By assessing the alterations associated with brain function, we found that B. breve HNXY26M4 attenuated cognitive deficits and suppressed neuroinflammation and synaptic dysfunction in APP/PS1 mice. Moreover, by determining the modulation effects of B. breve HNXY26M4 on gut homeostasis, we identified that B. breve HNXY26M4 supplementation restored the composition of gut microbiota and short-chain fatty acids, as well as enhanced the function of the intestinal barrier. These findings indicate that microbiome-derived acetate and butyrate modulated by B. breve HNXY26M4 administration may be transported to the brain through the blood–brain barrier, and thus confer neuroprotective effects against AD-associated brain deficits and inflammation via the gut–brain axis.
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Probiotic and prebiotic interventions aimed at elevating SCFA levels have neuroprotective effects in AD mouse models by inhibiting glial activation and Aβ deposition.
“Moreover, probiotic and prebiotic interventions aimed at elevating SCFA levels have demonstrated neuroprotective effects in AD mouse models by inhibiting glial activation and Aβ deposition.301–306”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [302]
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
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- Authors
- Zhu, G., Zhao, J., Wang, G., & Chen, W.
- Affiliations
- Jiangnan University (CN)
- Corresponding author
- Zhu, Guangsu
- Wang, Gang
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2023-03-08
- Volume
- 71
- Issue
- 11
- Pages
- 4646-4655
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W4323537878
- Cited by
- 84
- References
- 40
- Citations by year
- 2026: 21 · 2025: 28 · 2024: 25 · 2023: 10
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Central University Basic Research Fund of China (JUSRP22006, JUSRP51501)
- National Natural Science Foundation of China (31820103010, 31972052, 32021005)
- Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, gut-brain axis, cognitive impairment, neuroinflammation, synaptic dysfunction, APP/PS1 mice, gut microbiota, short-chain fatty acids, acetate, butyrate, intestinal barrier, blood-brain barrier, psychobiotics, neuroprotection
- MeSH terms
- Bifidobacterium breve, Brain-Gut Axis, Neuroinflammatory Diseases, Alzheimer Disease, Animals, Cognition, Mice, Transgenic, Amyloid beta-Protein Precursor, Neuroprotective Agents, Neurodegenerative Diseases, Mice, Cognitive Dysfunction
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