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Cited by 79Malaria Research and ControlPregnancy and preeclampsia studiesReproductive System and Pregnancy

Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria

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Kabyemela, Edward R, Muehlenbachs, Atis, Fried, Michal, Kurtis, Jonathan D, Mutabingwa, Theonest K, Duffy, Patrick E·2008·Malaria Journal
DOI 10.1186/1475-2875-7-26PMC PMC2265723
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Abstract

Background: Placental malaria (PM) is an important cause of maternal and foetal mortality in tropical areas, and severe sequelae and mortality are related to inflammation in the placenta. Diagnosis is difficult because PM is often asymptomatic, peripheral blood smear examination detects parasitemia as few as half of PM cases, and no peripheral markers have been validated for placental inflammation. Methods: In a cohort of Tanzanian parturients, PM was determined by placental blood smears and placental inflammation was assessed by histology and TNF mRNA levels. Maternal peripheral blood levels of several immune mediators previously implicated in PM pathogenesis, as well as ferritin and leptin were measured. The relationship between the levels of these soluble factors to PM and placental inflammation was examined. Results: Peripheral levels of TNF, TNF-RI, TNF-RII, IL-1, IL-10, and ferritin were elevated during PM, whereas levels of IFN-γ, IL-4, IL-5 and IL-6 were unchanged and levels of leptin were decreased. In receiver operating characteristic curve analysis, IL-10 had the greatest area under the curve, and would provide a sensitivity of 60% with a false positive rate of 10%. At a cut off level of 15 pg/mL, IL-10 would detect PM with a sensitivity of 79.5% and a specificity of 84.3%. IL-10 levels correlated with placental inflammatory cells and placental TNF mRNA levels in first time mothers. Conclusion: These data suggest that IL-10 may have utility as a biomarker for inflammatory PM in research studies, but that additional biomarkers may be required to improve clinical diagnosis and management of malaria during pregnancy.

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  • PM is associated with inflammatory immune responses, with increased levels of soluble mediators like TNF-α, TNF receptor I, TNF receptor II and IL-10 in peripheral blood.

    “PM is associated with inflammatory immune responses [75–79], with increased levels of soluble mediators like TNF-α, TNF receptor I, TNF receptor II and IL-10 in peripheral blood [80,81].”

    From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [80]

  • IL-10 has been proposed as a biomarker of placental infection and as a definitive marker of inflammation during placental malaria.

    “Other authors, based on high levels detected in serum of women with gestational malaria, have proposed IL-10 as biomarker of placental infection [33] and a definitive marker of inflammation during placental malaria [34].”

    From Submicroscopic infection of placenta by Plasmodium produces Th1/Th2 cytokine imbalance, inflammation and hypoxia in women from north-west Colombia (2014) · cites this paper as [34]

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Authors
Kabyemela, E. R., Muehlenbachs, A., Fried, M., Kurtis, J. D., Mutabingwa, T. K., & Duffy, P. E.
Affiliations
  • Center for Infectious Disease Research (US)
  • Brown University (US)
Corresponding author
Duffy, Patrick E
ORCID
Venue
Malaria Journal
Publisher
Springer Science and Business Media LLC
Published
2008-01-29
Volume
7
Issue
1
Pages
26-26
ISSN
1475-2875 (ISSN-L)
DOI
10.1186/1475-2875-7-26
PMC
PMC2265723
OpenAlex
W2094230544
Cited by
79
References
30
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 8
FWCI
6.29
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Malaria Journal (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Bill and Melinda Gates Foundation (29202)
  • Brown University
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (R01AI052059, R01AI52059)
  • Fogarty International Center (TW05509, D43TW005509)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
placental malaria, IL-10, biomarkers, placental inflammation, malaria in pregnancy, TNF-α, ferritin, leptin, maternal peripheral blood, primiparous women, placental histology
MeSH terms
Adolescent, Adult, Animals, Diagnosis, Differential, False Positive Reactions, Female, Ferritins, Humans, Inflammation, Middle Aged, Placenta, Placenta Diseases, Plasmodium falciparum, Pregnancy, Sensitivity and Specificity, Tanzania, Cohort Studies, Biomarkers, Pregnancy Complications, Parasitic, RNA, Protozoan, Polymerase Chain Reaction, Cytokines, Interleukin-10, Malaria, Falciparum

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