The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Mannose-Binding Lectin in Severe Acute Respiratory Syndrome Coronavirus Infection
Open accessAbstract
Little is known about the innate immune response to severe acute respiratory syndrome (SARS) coronavirus (CoV) infection. Mannose-binding lectin (MBL), a key molecule in innate immunity, functions as an ante-antibody before the specific antibody response. Here, we describe a case-control study that included 569 patients with SARS and 1188 control subjects and used in vitro assays to investigate the role that MBL plays in SARS-CoV infection. The distribution of MBL gene polymorphisms was significantly different between patients with SARS and control subjects, with a higher frequency of haplotypes associated with low or deficient serum levels of MBL in patients with SARS than in control subjects. Serum levels of MBL were also significantly lower in patients with SARS than in control subjects. There was, however, no association between MBL genotypes, which are associated with low or deficient serum levels of MBL, and mortality related to SARS. MBL could bind SARS-CoV in a dose- and calcium-dependent and mannan-inhibitable fashion in vitro, suggesting that binding is through the carbohydrate recognition domains of MBL. Furthermore, deposition of complement C4 on SARS-CoV was enhanced by MBL. Inhibition of the infectivity of SARS-CoV by MBL in fetal rhesus kidney cells (FRhK-4) was also observed. These results suggest that MBL contributes to the first-line host defense against SARS-CoV and that MBL deficiency is a susceptibility factor for acquisition of SARS
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Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923
Identification of a novel coronavirus in patients with severe acute respiratory syndrome
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A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
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Self-citationCoronavirus as a possible cause of severe acute respiratory syndrome
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Self-citationA Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong
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Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
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Self-citationThe Genome Sequence of the SARS-Associated Coronavirus
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Clinical Features and Short-term Outcomes of 144 Patients With SARS in the Greater Toronto Area
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Identification of Severe Acute Respiratory Syndrome in Canada
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Cited by
Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection
Cheng, V. C. C., Lau, S. K. P., Woo, P. C. Y., & Yuen, K. Y. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00023-07 · Cited by 1,192
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
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Ovsyannikova, I. G., Haralambieva, I. H., Crooke, S. N., Poland, G. A., & Kennedy, R. B. (2020) · Immunological Reviews · doi:10.1111/imr.12897 · Cited by 258
Ahmed-Hassan, H., Sisson, B., Shukla, R. K., Wijewantha, Y., Funderburg, N. T., Li, Z., Hayes, D., Demberg, T., & Liyanage, N. P. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01979 · Cited by 47
Metadata
- Authors
- Ip, W. K. E., Chan, K. H., Law, H. K. W., Tso, G. H. W., Kong, E. K. P., Wong, W. H. S., To, Y. F., Yung, R. W. H., Chow, E. Y., Au, K. L., Chan, E. Y. T., Lim, W., Jensenius, J. C., Turner, M. W., Peiris, J. S. M., & Lau, Y. L.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05
- Volume
- 191
- Issue
- 10
- Pages
- 1697-1704
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2145526657
- Cited by
- 284
- References
- 42
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ip, W. K. E., Chan, K. H., Law, H. K. W., Tso, G. H. W., Kong, E. K. P., Wong, W. H. S., To, Y. F., Yung, R. W. H., Chow, E. Y., Au, K. L., Chan, E. Y. T., Lim, W., Jensenius, J. C., Turner, M. W., Peiris, J. S. M., & Lau, Y. L. (2005). Mannose-Binding Lectin in Severe Acute Respiratory Syndrome Coronavirus Infection. The Journal of Infectious Diseases. https://doi.org/10.1086/429631
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
