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Cited by 174Reproductive tract infections researchHIV/AIDS Research and InterventionsSyphilis Diagnosis and Treatment

Patient-delivered partner treatment for male urethritis: a randomized, controlled trial.

Kissinger, P., Mohammed, H., Richardson-Alston, G., Leichliter, J. S., Taylor, S. N., Martin, D. H., Farley, T. A.·2005·Clinical Infectious Diseases
DOI 10.1086/432476
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Abstract

BACKGROUND: Traditional partner referral for sexually transmitted diseases (STDs) is ineffective at assuring that partners are treated. Alternative methods are needed. We sought to determine whether patient-delivered partner treatment (PDPT) is better than 2 different methods of partner referral in providing antibiotic treatment to sex partners of men with urethritis and in reducing recurrence of Chlamydia trachomatis and Neisseria gonorrhoeae. METHODS: Men who received a diagnosis of urethritis at a public STD clinic in New Orleans, Louisiana, during the period of December 2001 through March 2004 were randomly assigned according to the month of treatment for either standard partner referral (PR), booklet-enhanced partner referral (BEPR), or PDPT. At baseline and after 1 month, men were asked to provide information about each partner and were tested for C. trachomatis and N. gonorrhoeae. RESULTS: Most enrolled index men (n = 977) were > 24 years of age (51.6%) and African American (95%) and had > or = 2 partners (68.3%). They reported information on 1991 partners, and 78.8% were reinterviewed 4-8 weeks later. Men in the PDPT arm were more likely than men in the BEPR and PR arms to report having seen their partners, having talked to their partners about the infection, having given the intervention to their partners, and having been told by their partners that the antibiotic treatment had been taken (55.8%, 45.6%, and 35.0%, respectively; P < .001). Of men who were reinterviewed, 37.5% agreed to follow-up testing for N. gonorrhoeae and C. trachomatis infection. Those tested were similar to those not tested with regard to the study variables measured. Among those tested, men in the PDPT and BEPR arms were less likely than those in the PR arm to test positive for C. trachomatis and/or N. gonorrhoeae (23.0%, 14.3%, and 42.7%, respectively; P < .001). CONCLUSION: Among heterosexual men with urethritis, PDPT was better than standard partner referral for treatment of partners and prevention of recurrence of C. trachomatis or N. gonorrhoeae infection.

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Crossref · 10.1086/432476

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  • Two U.S. trials reported statistically significant decreases in the rate of reinfection, and one observed a lower risk for persistent or recurrent infection that was statistically nonsignificant.

    “Two reported statistically significant decreases in the rate of reinfection, and one observed a lower risk for persistent or recurrent infection that was statistically nonsignificant.”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [127]

  • All three U.S. trials reported that more partners were treated when patients were offered EPT.

    “All three trials reported that more partners were treated when patients were offered EPT.”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [127]

  • Across EPT trials, reductions in chlamydia prevalence at follow-up were approximately 20%, and reductions in gonorrhea were approximately 50% at follow-up.

    “However, across trials, reductions in chlamydia prevalence at follow-up were approximately 20%, and reductions in gonorrhea were approximately 50% at follow-up.”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [127]

  • Evidence supporting EPT is based on three U.S. clinical trials involving heterosexual men and women with chlamydia or gonorrhea.

    “Evidence supporting EPT is based on three U.S. clinical trials involving heterosexual men and women with chlamydia or gonorrhea (125–127).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [127]

  • U.S. trials and a meta-analysis of EPT revealed that the magnitude of reduction in reinfection of index patients, compared with patient referral, differed according to the STI and the sex of the index patient.

    “U.S. trials and a meta-analysis of EPT revealed that the magnitude of reduction in reinfection of index patients, compared with patient referral, differed according to the STI and the sex of the index patient (110,125–127).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [127]

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Authors
Kissinger, P., Mohammed, H., Richardson-Alston, G., Leichliter, J. S., Taylor, S. N., Martin, D. H., & Farley, T. A.
Affiliations
  • Tulane University (US)
  • Centers for Disease Control and Prevention (US)
  • Louisiana State University (US)
Corresponding author
Kissinger, P.
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2005-09-01
Volume
41
Issue
5
Pages
623-629
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/432476
OpenAlex
W2116355586
Cited by
174
References
17
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 11 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 2 · 2017: 9 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 7 · 2012: 8
FWCI
9.22
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centers for Disease Control and Prevention (R30/CCR619146)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
Keywords
urethritis, sexually transmitted infections, Chlamydia trachomatis, Neisseria gonorrhoeae, partner notification, infection recurrence prevention, men who have sex with men, STD clinic patients
MeSH terms
Adult, Anti-Bacterial Agents, Chlamydia Infections, Female, Gonorrhea, Humans, Male, Sexual Partners, Urethritis, Sexually Transmitted Diseases, Bacterial, Contact Tracing

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