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Two‐Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome
Open accessAbstract
In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16.
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Cites
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Cited by
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Metadata
- Authors
- Liu, W., Fontanet, A., Zhang, P., Zhan, L., Xin, Z., Baril, L., Tang, F., Lv, H., & Cao, W.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03-15
- Volume
- 193
- Issue
- 6
- Pages
- 792-795
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2141787825
- Cited by
- 285
- References
- 11
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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