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Cited by 147Antifungal resistance and susceptibilityFungal Infections and StudiesFungal and yeast genetics research

Contemporary tools for the diagnosis and management of invasive mycoses

Alexander, Barbara D., Pfaller, Michael A.·2006·Clinical Infectious Diseases
DOI 10.1086/504491
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Abstract

Invasive fungal infections have become a major cause of morbidity and mortality over the past 3 decades. Organ transplantation, the use of aggressive chemotherapy, and the availability and widespread use of immunosuppressive treatments for many medical ailments have resulted in large populations of patients who are at risk for fungal disease. Early diagnosis and prompt therapy are instrumental to successful treatment of these infections, but conventional methods for diagnosis of fungal disease are slow and lack sensitivity. Important advances in diagnosing invasive mycoses, particularly in laboratory-based testing, have been realized over the years. Antigen-based assays, new laboratory methods for identification of fungi, and reference guidelines for susceptibility testing have been developed and validated for use in clinical laboratories. We review these technological advances and our understanding of their clinical application and impact.

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Crossref · 10.1086/504491

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107 of 107 references verified0 citation errors · 0 not checkable

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  • Invasive candidiasis lacks specific and objective clinical findings.

    “Unfortunately, IC lacks specific and objective clinical findings.3,[50][51][52][53]”

    From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [50]

  • Changes in immunosuppressive regimens and improved efforts to document infection may have had a greater impact on the management of invasive aspergillosis than on that of invasive candidiasis.

    “On the other hand, changes in immunosuppressive regimens and improved efforts to document infection may have had a greater impact on the management of IA than on that of IC (4, 43, 44, 59, 80, 85, 164-166, 181, 266, 271, 274, 275, 276).”

    From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [4]

  • Antifungal susceptibility testing in vitro is playing an increasing role in antifungal drug selection, as an aid in drug development studies and as a means of tracking the development of antifungal resistance in epidemiologic studies.

    “Antifungal susceptibility testing in vitro is playing an increasing role in antifungal drug selection, as an aid in drug development studies and as a means of tracking the development of antifungal resistance in epidemiologic studies (4, 202, 253, 274).”

    From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [4]

  • The susceptibility of C. glabrata to fluconazole or other azoles in the setting of prior azole exposure is not predictable and requires confirmation by real-time antifungal susceptibility testing.

    “the susceptibility of this species to fluconazole, or other azoles in the setting of prior azole exposure, is not predictable and requires confirmation by 'real-time' antifungal susceptibility testing (4, 14, 91, 140, 186, 189, 274).”

    From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [4]

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Authors
Alexander, B. D., & Pfaller, M. A.
Affiliations
  • Duke University (US)
  • University of Iowa (US)
Corresponding author
Alexander, Barbara D.
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2006-08-01
Volume
43
Issue
Supplement_1
Pages
S15-S27
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/504491
OpenAlex
W2043365705
Cited by
147
References
107
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 11 · 2014: 7 · 2013: 9 · 2012: 7
FWCI
8.47
Type
journal article
Language
en
Open access
closed
Locations
Clinical Infectious Diseases (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
invasive fungal infections, fungal infection diagnosis, fungal identification, antifungal susceptibility testing, immunosuppression, organ transplantation, chemotherapy, clinical laboratory testing

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