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Clinical applications of decellularized extracellular matrices for tissue engineering and regenerative medicine
Open accessAbstract
Decellularization is the process of removing the cellular components from tissues or organs. It is a promising technology for obtaining a biomaterial with a highly preserved extracellular matrix (ECM), which may also act as a biological scaffold for tissue engineering and regenerative therapies. Decellularized products are gaining clinical importance and market space due to their ease of standardized production, constant availability for grafting and mechanical or biochemical superiority against competing clinical options, yielding clinical results ahead of the ones with autografts in some applications. Current drawbacks and limitations of traditional treatments and clinical applications can be overcome by using decellularized or acellular matrices. Several companies are leading the market with versatile acellular products designed for diverse use in the reconstruction of tissues and organs. This review describes ECM-based decellularized and acellular products that are currently in use for different branches of clinic.
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“While xenogeneic ECM has the potential to cause immune responses, this risk can be greatly reduced by using proper preparation techniques64; similar ECM scaffolds derived from animals are FDA-approved for clinical applications such as heart valve replacement, facial reconstruction, and osteopathic implants62,65.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [65]
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Metadata
- Authors
- Parmaksiz, M., Dogan, A., Odabas, S., Elçin, A. E., & Elçin, Y. M.
- Affiliations
- Ankara University Faculty of Science, and Ankara University Stem Cell Institute
- Ankara University (TR)
- Corresponding author
- Elçin, A Eser
- Elçin, Y Murat
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2016-03-17
- Volume
- 11
- Issue
- 2
- Pages
- 022003
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- OpenAlex
- W2314454902
- Cited by
- 268
- References
- 155
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 30 · 2023: 30 · 2022: 29 · 2021: 38 · 2020: 32 · 2019: 27 · 2018: 27 · 2017: 15 · 2016: 4
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomedical Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- decellularized extracellular matrix, tissue engineering scaffolds, regenerative medicine, clinical application, biomaterials, tissue grafting, autograft alternative, tissue reconstruction
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Humans, Plastic Surgery Procedures, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds
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