Cited by 268Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchBone Tissue Engineering Materials

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Clinical applications of decellularized extracellular matrices for tissue engineering and regenerative medicine

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Parmaksiz, Mahmut, Dogan, Arin, Odabas, Sedat, Elçin, A Eser, Elçin, Y Murat·2016·Biomedical Materials

DOI 10.1088/1748-6041/11/2/022003

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Abstract

Decellularization is the process of removing the cellular components from tissues or organs. It is a promising technology for obtaining a biomaterial with a highly preserved extracellular matrix (ECM), which may also act as a biological scaffold for tissue engineering and regenerative therapies. Decellularized products are gaining clinical importance and market space due to their ease of standardized production, constant availability for grafting and mechanical or biochemical superiority against competing clinical options, yielding clinical results ahead of the ones with autografts in some applications. Current drawbacks and limitations of traditional treatments and clinical applications can be overcome by using decellularized or acellular matrices. Several companies are leading the market with versatile acellular products designed for diverse use in the reconstruction of tissues and organs. This review describes ECM-based decellularized and acellular products that are currently in use for different branches of clinic.

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Authors: Parmaksiz, M., Dogan, A., Odabas, S., Elçin, A. E., & Elçin, Y. M.
Affiliations: Ankara University Faculty of Science, and Ankara University Stem Cell Institute
Ankara University (TR)
Corresponding author: Elçin, A Eser
Elçin, Y Murat
ORCID: Elçin, A Eser
Elçin, Y Murat
Venue: Biomedical Materials
Publisher: IOP Publishing
Published: 2016-03-17
Volume: 11
Issue: 2
Pages: 022003
ISSN: 1748-6041 (ISSN-L)
1748-605X
DOI: 10.1088/1748-6041/11/2/022003
OpenAlex: W2314454902
Cited by: 268
References: 155
Citations by year: 2026: 12 · 2025: 23 · 2024: 30 · 2023: 30 · 2022: 29 · 2021: 38 · 2020: 32 · 2019: 27 · 2018: 27 · 2017: 15 · 2016: 4
FWCI: 4.82
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: publishingsupport.iopscience.iop.org/iop-standard/v1 (vor)
iopscience.iop.org/info/page/text-and-data-mining (tdm)
Locations: Biomedical Materials (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords: decellularized extracellular matrix, tissue engineering scaffolds, regenerative medicine, clinical application, biomaterials, tissue grafting, autograft alternative, tissue reconstruction
MeSH terms: Animals, Biocompatible Materials, Extracellular Matrix, Humans, Plastic Surgery Procedures, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds

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Clinical applications of decellularized extracellular matrices for tissue engineering and regenerative medicine

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