Clinical applications of decellularized extracellular matrices for tissue engineering and regenerative medicine

Tissue engineering

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Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix

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Clinical Applications of Injectable Biomaterials

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High-Performance Acellular Tissue Scaffold Combined with Hydrogel Polymers for Regenerative Medicine

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Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies

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Comparison of Bovine- and Porcine-Derived Decellularized Biomaterials: Promising Platforms for Tissue Engineering Applications

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Extracellular matrix-based biomaterials in burn wound repair: A promising therapeutic strategy

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Potential Synergistic Effects of Stem Cells and Extracellular Matrix Scaffolds

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Clinical and surgical aspects of medical materials’ biocompatibility

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Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine

Francés‐Herrero, E., Rodríguez‐Eguren, A., Gómez‐Álvarez, M., de Miguel–Gómez, L., Ferrero, H., & Cervelló, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073765 · Cited by 23

Bioorthogonal Modification of Cell Derived Matrices by Metabolic Glycoengineering

Gutmann, M., Braun, A. C., Seibel, J., & Lühmann, T. C. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00264 · Cited by 22

Resveratrol‐loaded decellularized ovine pericardium: ECM introduced for tissue engineering

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Advances in Recellularization of Decellularized Liver Grafts with Different Liver (Stem) Cells: Towards Clinical Applications

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Advanced Graft Development Approaches for ACL Reconstruction or Regeneration

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Decellularization of various tissues and organs through chemical methods

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Effects of chemical and physical methods on decellularization of murine skeletal muscles

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Extracellular matrix in epitheliochorial, endotheliochorial and haemochorial placentation and its potential application for regenerative medicine

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A bioartificial rat heart tissue: Perfusion decellularization and characterization

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Autologous protein-based scaffold composed of platelet lysate and aminated hyaluronic acid

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3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets

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Composite PLGA–Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration

Pouroutzidou, G. K., Papadopoulou, L., Lazaridou, M., Tsachouridis, K., Papoulia, C., Patsiaoura, D., Tsamesidis, I., Chrissafis, K., Vourlias, G., Paraskevopoulos, K., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030819 · Cited by 19

From cells to organs: progress and potential in cartilaginous organoids research

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Human decellularized adipose tissue hydrogels as a culture platform for human adipose-derived stem cell delivery

Pu, W., Han, Y., & Yang, M. (2021) · Journal of Applied Biomaterials & Functional Materials · doi:10.1177/2280800020988141 · Cited by 19

Chemical modification of acellular fish skin as a promising biological scaffold by carbodiimide cross‐linker for wound healing

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Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

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In vitro and in vivo biocompatibility of decellularized cellulose scaffolds functionalized with chitosan and platelet rich plasma for tissue engineering applications

Mahendiran, B., Muthusamy, S., Sampath, S., Jaisankar, S. N., Selvakumar, R., & Krishnakumar, G. S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.052 · Cited by 18

Decellularization of Porcine Carotid Arteries: From the Vessel to the High-Quality Scaffold in Five Hours

Massaro, M. S., Kochová, P., Pálek, R., Rosendorf, J., Červenková, L., Dahmen, U., Liška, V., & Moulisová, V. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.833244 · Cited by 17

Bioactive wound powders as wound healing dressings and drug delivery systems

Emami, S., & Ebrahimi, M. (2023) · Powder Technology · doi:10.1016/j.powtec.2023.118501 · Cited by 20

ECM-derived biomaterials for regulating tissue multicellularity and maturation

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Multi-level collagen aggregates and their applications in biomedical applications

Dan, W., Chen, Y., Dan, N., Zheng, X. H., Wang, L., Yang, C., Huang, Y., Liu, X., & Hu, Y. (2019) · International Journal of Polymer Analysis and Characterization · doi:10.1080/1023666x.2019.1656387 · Cited by 17

Injectable human decellularized adipose tissue hydrogel containing stem cells enhances wound healing in mouse

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Decellularized hASCs-derived matrices as biomaterials for 3D in vitro approaches

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Advances on the modification and biomedical applications of acellular dermal matrices

Chen, Y., Liu, X., Zheng, X. H., Huang, X., Dan, W., Li, Z., Dan, N., & Wang, Y. (2022) · Journal of Leather Science and Engineering · doi:10.1186/s42825-022-00093-4 · Cited by 16

Decellularized tissues and organs: an historical perspective and prospects for the future

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Engineering human bone grafts with new macroporous calcium phosphate cement scaffolds

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Preparation and Evaluation of Tibia- and Calvarium-Derived Decellularized Periosteum Scaffolds

Zhang, J., Zhang, Q., Chen, J., Ni, J., Zeng, Z., Wang, G., Song, L., Fan, S., Chen, P., & Lin, X. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00548 · Cited by 16

Robust Fabrication of Composite 3D Scaffolds with Tissue-Specific Bioactivity: A Proof-of-Concept Study

Krishnamoorthi, M. K., Sarig, U., Baruch, L., Ting, S., Reuveny, S., Oh, S., Goldfracht, I., Gepstein, L., Venkatraman, S. S., Tan, L. P., et al. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00310 · Cited by 16

Bioactive composite hydrogels as 3D mesenchymal stem cell encapsulation environment for bone tissue engineering: in vitro and in vivo studies

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A decellularized and sterilized human meniscus allograft for off‐the‐shelf meniscus replacement

Spierings, J., Velthuijs, W., Mansoor, A., Bertrand, M. E., Uquillas, J. A., Ito, K., Janssen, R. P. A., & Foolen, J. (2022) · Journal of Experimental Orthopaedics · doi:10.1186/s40634-022-00555-y · Cited by 15

Role of immediate early genes in the development of salivary gland organoids in polyisocyanopeptide hydrogels

Schaafsma, P., Kracht, L., Baanstra, M., Bruin, A. L. J.-D., & Coppes, R. P. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1100541 · Cited by 16

Stabilized human amniotic membrane for enhanced sustainability and biocompatibility

Bhawna, Gujjar, S., Venkataprasanna, K. S., Tiwari, S., Sharma, J. C., Sharma, P., Pujani, M., Pandey, A. K., Abnave, P., Kalyanasundaram, D., et al. (2023) · Process Biochemistry · doi:10.1016/j.procbio.2023.03.009 · Cited by 15

Novel muscle-derived extracellular matrix hydrogel promotes angiogenesis and neurogenesis in volumetric muscle loss

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Mussel-Inspired Dopamine and Carbon Nanotube Leading to a Biocompatible Self-Rolling Conductive Hydrogel Film

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Bone-Derived Extracellular Matrix Hydrogel from Thrombospondin-2 Knock-Out Mice for Bone Repair

Chen, Z., Zhang, J., Lee, F. Y., & Kyriakides, T. R. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.08.011 · Cited by 14

Decellularized human corneal stromal cell sheet as a novel matrix for ocular surface reconstruction

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An off-the-shelf decellularized and sterilized human bone-ACL-bone allograft for anterior cruciate ligament reconstruction

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Comparative Decellularization and Recellularization of Normal Versus Streptozotocin‐Induced Diabetes Mellitus Rat Pancreas

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Biomedical Applications: Liposomes and Supported Lipid Bilayers for Diagnostics, Theranostics, Imaging, Vaccine Formulation, and Tissue Engineering

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3D Bioprinting of Tissue Models with Customized Bioinks

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Natural Architectures for Tissue Engineering and Regenerative Medicine

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Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations

Aytekin, E., Vurat, M. T., Elçin, A. E., & Elçin, Y. M. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300295 · Cited by 13

Characterisation of Matrix-Bound Nanovesicles (MBVs) Isolated from Decellularised Bovine Pericardium: New Frontiers in Regenerative Medicine

Francesco, D. D., Varsavia, C. D., Casarella, S., Donetti, E., Manfredi, M., Mantovani, D., & Boccafoschi, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020740 · Cited by 12

The considerations on selecting the appropriate decellularized ECM for specific regeneration demands

Zhang, S., Guo, Y., Lu, Y., Liu, F., Heng, B. C., & Deng, X. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101301 · Cited by 13

Design and Fabrication of an Automatable, 3D Printed Perfusion Device for Tissue Infusion and Perfusion Engineering

Schilling, B. K., Lamberti, K. K., Snowden, M. J., Baker, J. S., Byrd, K., Komatsu, C., Solari, M. G., & Marra, K. G. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2019.0209 · Cited by 13

Engineered mucoperiosteal scaffold for cleft palate regeneration towards the non-immunogenic transplantation

Rizzo, M. I., Tomao, L., Tedesco, S., Cajozzo, M., Esposito, M., Stefanis, C. D., Ferranti, A. M., Mezzogori, D., Palmieri, A., Pozzato, G., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93951-w · Cited by 12

Peripheral Nerve Decellularization for In Vitro Extracellular Matrix Hydrogel Use: A Comparative Study

Gregory, E., Baek, I., Ala-Kokko, N., Dugan, R., Pinzon‐Herrera, L., Almodóvar, J., & Song, Y. H. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00034 · Cited by 13

Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations

Parmaksız, M. (2022) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2022.105387 · Cited by 13

Biodegradable polyurethane-incorporating decellularized spinal cord matrix scaffolds enhance Schwann cell reprogramming to promote peripheral nerve repair

Wang, Y., Lin, J., Chen, J., Liang, R., Zhang, Q., Li, J., Shi, M., Li, L., He, X., Lan, T., et al. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02679a · Cited by 13

Customized 3D printed bioreactors for decellularization—High efficiency and quality on a budget

Grab, M., Stieglmeier, F., Emrich, J., Grefen, L., Leone, A., König, F., Hagl, C. M., & Thierfelder, N. (2021) · Artificial Organs · doi:10.1111/aor.14034 · Cited by 13

Application of decellularized tissue for soft-hard interregional regeneration

Suzuki, M., Kimura, T., Hashimoto, Y., & Kishida, A. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1394714 · Cited by 12

Efficacy of Human Cell-Seeded Muscle-Stuffed Vein Conduit in Rat Sciatic Nerve Repair

Ramli, K., Gasim, I. A., Ahmad, A. A., Htwe, O., Haflah, N. H. M., Law, Z. K., Hasan, S., Naicker, A. S., Mokhtar, S. A., Ariffin, M. H. M., et al. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0279 · Cited by 12

Chick Embryo Experimental Platform for Micrometastases Research in a 3D Tissue Engineering Model: Cancer Biology, Drug Development, and Nanotechnology Applications

Guller, A., Kuschnerus, I. C., Rozova, V. S., Nadort, A., Yao, Y., Khabir, Z., Garcia‐Bennett, A. E., Liang, L., Polikarpova, A., Qian, Y., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9111578 · Cited by 12

Decellularized bSIS-ECM as a Regenerative Biomaterial for Skin Wound Repair

Parmaksız, M., Elçin, A. E., & Elçin, Y. M. (2018) · Methods in molecular biology · doi:10.1007/7651_2018_147 · Cited by 12

Region-specific brain decellularized extracellular matrix promotes cell recovery in an in vitro model of stroke

Reginensi, D., Ortiz, D. A., Denis, B., Castillo, S., Burillo, A., Khoury, N., Xu, J., Dam, M. L., Escobar, A. A. H., Dave, K. R., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-95656-w · Cited by 11

Advanced Biotechnologies Toward Engineering a Cell Home for Stem Cell Accommodation

Tian, B., He, X., Xu, X., Li, X., Wu, R., & Chen, F. (2017) · Advanced Materials Technologies · doi:10.1002/admt.201700022 · Cited by 11

Decellularised porcine peritoneum as a tendon protector sheet

Capella-Monsonís, H., Kelly, J., Kearns, S., & Zeugolis, D. I. (2019) · Biomedical Materials · doi:10.1088/1748-605x/ab2301 · Cited by 11

Assessment of dopamine-conjugated decellularized bovine tendon extracellular matrix as a bioadhesive

Ercan, H., Elçin, A. E., & Elçin, Y. M. (2022) · Materials Today Communications · doi:10.1016/j.mtcomm.2022.103634 · Cited by 11

Tissue Regeneration

Kaoud, H. A. H. E.-S. (2018) · InTech eBooks · doi:10.5772/intechopen.70922 · Cited by 11

Recent advances of functional modules for tooth regeneration

Wang, X., Chen, Q., Li, J., Tian, W., Zhi, L., & Tian, C. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01027b · Cited by 10

Decellularized matrix could affect the proliferation and differentiation of periodontal ligament stem cells in vitro

Huang, J., Wu, Y., Liu, J., Zhang, L., Li, B., Chen, L., Ding, P., & Tan, J. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12889 · Cited by 10

Construction of a decellularized spinal cord matrix/GelMA composite scaffold and its effects on neuronal differentiation of neural stem cells

He, W., Wang, H., Zhang, X., Mao, T., Lu, Y., Gu, Y., Ju, D., Qi, L., Wang, Q., & Dong, C. (2022) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2022.2102275 · Cited by 10

Decellularized Scaffold-Based Artificial Vascular Patch for Porcine Vascular Repair

Liu, C., Gao, H., Sun, G., Jiang, X., Song, S., Zhang, J., & Shen, J. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00957 · Cited by 10

Advances in tissue engineering approaches for repairing and rehabilitating the myotendinous junction

Shama, K. A., Turner, M., Broadaway, H. B., Aikman, E. L., Stoppel, W. L., & Taylor, B. (2024) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2024.100532 · Cited by 10

Mesenchymal stem cell-derived extracellular matrix for musculoskeletal tissue regeneration

Lv, S., Wang, J., Chen, J., Yu, Y., Xinying, H., Zhao, G., Zhou, X., & Xu, Y. X. (2026) · Communications Biology · doi:10.1038/s42003-026-09638-3 · Cited by 9

Decellularization and In Vivo Recellularization of Abdominal Porcine Fascial Tissue

Sánchez, J. C., Díaz, D. M., Sánchez, L. V., Valencia-Vásquez, A., Quintero-Moreno, J. F., Muñoz, L. V., Bernal, A. F., Osorio, G., Guerra, Á., & Buitrago, J. (2020) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-020-00314-z · Cited by 9

Auto-Allo Graft Parallel Juxtaposition for Improved Neuroregeneration in Peripheral Nerve Reconstruction Based on Acellular Nerve Allografts

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Navigating the Immunological Crossroads: Mesenchymal Stem/Stromal Cells as Architects of Inflammatory Harmony in Tissue-Engineered Constructs

Farzamfar, S., Garcia, L., Rahmani, M., & Bolduc, S. (2024) · Bioengineering · doi:10.3390/bioengineering11050494 · Cited by 10

Effects of ECM Components on Periodontal Ligament Stem Cell Differentiation Under Conditions of Disruption of Wnt and TGF-β Signaling Pathways

Kuznetsova, A. V., Попова, О. П., Danilova, T. I., Latyshev, A. V., Yanushevich, O. O., & Aa, I. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16030094 · Cited by 8

Synthetic scaffolds functionalized with mesenchymal stem/stromal cells-derived extracellular matrix for bone tissue engineering: a review

Domingues, M. F., Carvalho, M. S., Sanjuan‐Alberte, P., & Silva, J. C. (2025) · RSC Advances · doi:10.1039/d5ra02106e · Cited by 8

Decellularized Matrix Induced Spontaneous Odontogenic and Osteogenic Differentiation in Periodontal Cells

Aa, I., Danilova, T. I., Kuznetsova, A. V., Попова, О. П., & Yanushevich, O. O. (2023) · Biomolecules · doi:10.3390/biom13010122 · Cited by 8

In vitro and in vivo assessment of a new acellular human amnion/chorion membrane device for guided bone regeneration

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3D‐printed Engineered Trachea Functionalized by Diverse Extracellular Matrix Particles

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