Cited by 269Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin Effects

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Redox Signaling Across Cell Membranes

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Fisher, Aron B.·2009·Antioxidants & Redox Signaling

DOI 10.1089/ars.2008.2378PMC PMC2842114

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Abstract

Generation of reactive oxygen species (ROS) by plasma membrane-localized NADPH oxidase (Nox 2) is a major mechanism of cell signaling associated with activation of the enzyme by a variety of agonists. With activation, the integral membrane flavocytochrome of Nox 2 transfers an electron from intracellular NADPH to extracellular O(2), generating superoxide anion (O(2)(*-)). The latter dismutes to H(2)O(2) which can diffuse through aquaporin channels in the plasma membrane to elicit an intracellular signaling response. O(2)(*-) also can initiate intracellular signaling by penetration of the cell membrane through anion channels (Cl(-) channel-3, ClC-3). Endosomes containing Nox2 and ClC-3 (called signaling endosomes) are composed of internalized plasma membrane and generate O(2)(*-) in the endosomal lumen to initiate signaling at intracellular sites. Thus, cellular signaling by Nox2 is dependent on the transmembrane flux of ROS. The role of this pathway has only recently been described and will require additional investigation to appreciate its physiological significance fully.

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Authors: Fisher, A. B.
Affiliations: University of Pennsylvania (US)
Corresponding author: Fisher, Aron B.
ORCID: Fisher, Aron B.
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2009-06
Volume: 11
Issue: 6
Pages: 1349-1356
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2008.2378
PMC: PMC2842114
OpenAlex: W2049637089
Cited by: 269
References: 62
Citations by year: 2026: 14 · 2025: 12 · 2024: 12 · 2023: 15 · 2022: 15 · 2021: 16 · 2020: 23 · 2019: 22 · 2018: 23 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 15 · 2013: 13 · 2012: 5
FWCI: 4.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: NADPH oxidase 2, reactive oxygen species, superoxide, hydrogen peroxide, aquaporins, ClC-3 chloride channel, signaling endosomes, redox signaling, plasma membrane, flavocytochrome
MeSH terms: Animals, Cell Membrane, Humans, Models, Biological, Oxidation-Reduction, Superoxides, Signal Transduction, Reactive Oxygen Species

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