The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Oxidative Stress in Hypertension: Role of the Kidney
Open accessAbstract
SIGNIFICANCE: Renal oxidative stress can be a cause, a consequence, or more often a potentiating factor for hypertension. Increased reactive oxygen species (ROS) in the kidney have been reported in multiple models of hypertension and related to renal vasoconstriction and alterations of renal function. Nicotinamide adenine dinucleotide phosphate oxidase is the central source of ROS in the hypertensive kidney, but a defective antioxidant system also can contribute. RECENT ADVANCES: Superoxide has been identified as the principal ROS implicated for vascular and tubular dysfunction, but hydrogen peroxide (H2O2) has been implicated in diminishing preglomerular vascular reactivity, and promoting medullary blood flow and pressure natriuresis in hypertensive animals. CRITICAL ISSUES AND FUTURE DIRECTIONS: Increased renal ROS have been implicated in renal vasoconstriction, renin release, activation of renal afferent nerves, augmented contraction, and myogenic responses of afferent arterioles, enhanced tubuloglomerular feedback, dysfunction of glomerular cells, and proteinuria. Inhibition of ROS with antioxidants, superoxide dismutase mimetics, or blockers of the renin-angiotensin-aldosterone system or genetic deletion of one of the components of the signaling cascade often attenuates or delays the onset of hypertension and preserves the renal structure and function. Novel approaches are required to dampen the renal oxidative stress pathways to reduced O2(-•) rather than H2O2 selectivity and/or to enhance the endogenous antioxidant pathways to susceptible subjects to prevent the development and renal-damaging effects of hypertension.
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Cites
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789
Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734
The role of oxidative stress in the pathophysiology of hypertension
Rodrigo, R., González, J., & Paoletto, F. (2011) · Hypertension Research · doi:10.1038/hr.2010.264 · Cited by 436 · cited 1×
“Comprehensive reviews on the generation and actions of ROS in vascular and cardiac systems have been published recently (88, 104, 192, 193, 199, 203, 204, 242, 255, 317, 319).”
BackgroundDrummond, G. R., Cai, H., Davis, M. E., Ramasamy, S., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.86.3.347 · Cited by 430
Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383
Dikalov, S. I., & Nazarewicz, R. R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4604 · Cited by 356 · cited 1×
“Trx proteins are abundant in the renal tubules (52), especially in PTs and distal tubules (DTs), while lower levels are reported in glomerular cells (54, 211).”
BackgroundA Mouse Model of Angiotensin II Slow Pressor Response: Role of Oxidative Stress
Kawada, N., Imai, E., Karber, A., Welch, W. J., & Wilcox, C. S. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000035087.11758.ed · Cited by 195
Self-citationCai, H., Davis, M. E., Drummond, G. R., & Harrison, D. G. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/hq1001.097028 · Cited by 160
Mechanisms of pressure natriuresis
Granger, J. P., Alexander, B. T., & Llinas, M. (2002) · Current Hypertension Reports · doi:10.1007/s11906-002-0040-3 · Cited by 117
Role of NOX2 in the regulation of afferent arteriole responsiveness
Carlström, M., Lai, E. Y., Ma, Z., Patzak, A., Brown, R. D., & Persson, A. E. G. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90718.2008 · Cited by 65
Cited by
Renal Autoregulation in Health and Disease
Carlström, M., Wilcox, C. S., & Arendshorst, W. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00042.2012 · Cited by 485
Self-citationPathophysiology of Hypertension: The Mosaic Theory and Beyond
Harrison, D. G., Coffman, T. M., & Wilcox, C. S. (2021) · Circulation Research · doi:10.1161/circresaha.121.318082 · Cited by 365
Self-citationOxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies
Montezano, A. C., Dulak-Lis, M., Tsiropoulou, S., Harvey, A., Briones, A. M., & Touyz, R. M. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.02.008 · Cited by 323
Stevenson, M. D., Vendrov, A. E., Yang, X., Chen, Y., Navarro, H. A., Moss, N., Runge, M. S., Arendshorst, W. J., & Madamanchi, N. R. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00236.2022 · Cited by 8
Metadata
- Authors
- Araujo, M., & Wilcox, C. S.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2014-01
- Volume
- 20
- Issue
- 1
- Pages
- 74-101
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2056024606
- Cited by
- 187
- References
- 12
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- green
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