Adverse Reactions to Methylphenidate Treatment for Attention-Deficit/Hyperactivity Disorder: Structure and Associations with Clinical Characteristics and Symptom Control
Abstract
BACKGROUND: Methylphenidate (MPH)-related adverse events are well characterized. Their predictors and their relationship with therapeutic effects are less well understood. Here we examine these issues in relation to two long-acting formulations. METHOD: Comparison of Methylphenidates in the Analog Classroom Setting (COMACS) was made in a large (n = 184) placebo-controlled trial comparing Equasym XL/Metadate CD, Concerta, and placebo (PLA) using a Laboratory School protocol. Therapeutic effects were measured using direct observation, scores on a simple math productivity task and parent ratings. Parents also completed the Barkley Stimulant Side Effect Rating Scale (BSSERS). RESULTS: The BSSERS had six factors: Emotionality, sleep/appetite, disengaged, dizzy, uninterested, and aches. Treatment effects were seen only for emotionality (which improved) and sleep and appetite (which worsened). Adverse events were not predictable from personal and clinical characteristics of patients. Sleep/appetite adverse events were not associated with therapeutic effects. Improvements in attention-deficit/hyperactivity disorder (ADHD) and emotionality were correlated. DISCUSSION: The results support a narrow conceptualization of MPH adverse events with problems restricted to appetite and sleep. These effects were not predictable on the basis of available information and may be due to an underlying mechanism rather distinct from those determining therapeutic effects.
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It is difficult to predict which children with ADHD will have adverse effects based upon demographic and clinical characteristics.
“Some research suggests that it is difficult to predict which children with ADHD will have adverse effects, based upon demographic and clinical characteristics [53].”
From Advances in understanding and treating ADHD (2011) · cites this paper as [53]
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- Authors
- Sonuga-Barke, E. J. S., Coghill, D., Wigal, T., DeBacker, M., & Swanson, J.
- Affiliations
- Ghent University (BE)
- University of Dundee (GB)
- University of California, Irvine (US)
- UCB Pharma (Belgium) (BE)
- Venue
- Journal of Child and Adolescent Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2009-12
- Volume
- 19
- Issue
- 6
- Pages
- 683-690
- ISSN
- 1044-5463 (ISSN-L)
- 1557-8992
- OpenAlex
- W1990746659
- Cited by
- 71
- References
- 31
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 8
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child and Adolescent Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- methylphenidate, attention deficit hyperactivity disorder, adverse drug reactions, long-acting formulations, sleep disorders, appetite loss, emotionality, symptom management, predictors of adverse events, stimulant side effects
- MeSH terms
- Central Nervous System Stimulants, Appetite, Attention Deficit Disorder with Hyperactivity, Child, Delayed-Action Preparations, Female, Humans, Male, Methylphenidate, Psychiatric Status Rating Scales, Severity of Illness Index, Sleep, Treatment Outcome, Expressed Emotion
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