The oral microbiota: Living with a permanent guest
Open accessAbstract
The oral cavity of healthy individuals contains hundreds of different bacterial, viral, and fungal species. Many of these can associate to form biofilms, which are resistant to mechanical stress or antibiotic treatment. Most are also commensal species, but they can become pathogenic in responses to changes in the environment or other triggers in the oral cavity, including the quality of an individual's personal hygiene. The complexity of the oral microbiome is being characterized through the newly developed tools of metagenomics. How the microbiome of the oral cavity contributes to health and disease is attracting the interest of a growing number of cell biologists, microbiologists, and immunologists.
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Induction and progression of periodontal disease are promoted by a dysbiosis of the oral commensal microbiota, which may affect the host's immune defenses, causing an inflammatory response that ultimately leads to destruction of the periodontium in a susceptible host.
“The induction and progression of the disease are promoted by a dysbiosis of the oral commensal microbiota, which may affect the host’s immune defenses, causing an inflammatory response that ultimately leads to irredeemable destruction of the periodontium (i.e., alveolar bone and periodontal ligament) in a susceptible host [7,8,9].”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [7]
Alterations in the oral microbiota are responsible for developing and promoting many oral diseases, including periodontal disease.
“It is now known that alterations in the oral microbiota are responsible for developing and promoting many oral diseases, including periodontal disease.”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [7]
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- Authors
- Avila, M., Ojcius, D. M., & Yilmaz, Ö.
- Affiliations
- University of California, Merced (US)
- University of Florida (US)
- Corresponding author
- Ojcius, David M.
- Yilmaz, Özlem
- Venue
- DNA and Cell Biology
- Publisher
- SAGE Publications
- Published
- 2009-08
- Volume
- 28
- Issue
- 8
- Pages
- 405-411
- ISSN
- 1044-5498 (ISSN-L)
- 1557-7430
- PMC
- PMC2768665
- OpenAlex
- W2046118138
- Cited by
- 482
- References
- 58
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 23 · 2023: 31 · 2022: 32 · 2021: 53 · 2020: 38 · 2019: 32 · 2018: 45 · 2017: 41 · 2016: 21 · 2015: 33 · 2014: 25 · 2013: 14 · 2012: 24
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- DNA and Cell Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Scholarly Commons (University of the Pacific) (submittedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R56DE016593, R01DE016593, R01DE019444)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- oral microbiota, biofilm, commensal bacteria, oral pathogens, metagenomics, oral hygiene, host-microbe interactions
- MeSH terms
- Antibiosis, Humans, Mouth, Mouth Diseases, Species Specificity, Ecosystem, Host-Pathogen Interactions, Metagenome
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