Cited by 1,121Oral microbiology and periodontitis researchGut microbiota and healthOral Health Pathology and Treatment

Oral microbiome: Unveiling the fundamentals

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Deo, PriyaNimish, Deshmukh, Revati·2019·Journal of Oral and Maxillofacial Pathology

Abstract

The oral cavity has the second largest and diverse microbiota after the gut harboring over 700 species of bacteria. It nurtures numerous microorganisms which include bacteria, fungi, viruses and protozoa. The mouth with its various niches is an exceptionally complex habitat where microbes colonize the hard surfaces of the teeth and the soft tissues of the oral mucosa. In addition to being the initiation point of digestion, the oral microbiome is crucial in maintaining oral as well as systemic health. Because of the ease of sample collection, it has become the most well-studied microbiome till date. Previously, studying the microbiome was limited to the conventional culture-dependent techniques, but the abundant microflora present in the oral cavity could not be cultured. Hence, studying the microbiome was difficult. The emergence of new genomic technologies including next-generation sequencing and bioinformatics has revealed the complexities of the oral microbiome. It has provided a powerful means of studying the microbiome. Understanding the oral microbiome in health and disease will give further directions to explore the functional and metabolic alterations associated with the diseased states and to identify molecular signatures for drug development and targeted therapies which will ultimately help in rendering personalized and precision medicine. This review article is an attempt to explain the different aspects of the oral microbiome in health.

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Research works printed but not linked: 4

  1. [11]Sowmya Y A review on the human oral microflora Res Rev 2016 4 1 5
  2. [13]Batabyal B Chakraborty S Biswas S Role of the oral microflora in human population: A brief review Int J Pharm Life Sci 2012 3 2220 7
  3. [40]The New Science of Metagenomics: Revealing the Secrets of Our Microbial Planet 2007 Last accessed on 2018 Dec 03 Washington (DC) National Academies Press (US) Available from: https://www.ncbi.nlm.nih.gov/books/NBK54006/ 21678629
  4. [50]Moon JH Lee JH Probing the diversity of healthy oral microbiome with bioinformatics approaches BMB Rep 2016 49 662 70 27697111 PMC5346311

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Authors
Deo, P., & Deshmukh, R.
Affiliations
Bharati Vidyapeeth (Deemed to be University) (IN)
Venue
Journal of Oral and Maxillofacial Pathology
Published
2019
Volume
23
Issue
1
Pages
122
ISSN
0973-029X (ISSN-L)
OpenAlex
W2952216579
Cited by
1,121
References
48
Citations by year
2026: 162 · 2025: 214 · 2024: 238 · 2023: 191 · 2022: 140 · 2021: 129 · 2020: 38 · 2019: 7
FWCI
87.84
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Journal of Oral and Maxillofacial Pathology (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
Keywords
oral microbiota, oral health, oral diseases, microbial colonization, oral mucosa, dental plaque, next-generation sequencing, precision medicine

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