Evolution of the human diet: Linking our ancestral diet to modern functional foods as a means of chronic disease prevention
Abstract
The evolution of the human diet over the past 10,000 years from a Paleolithic diet to our current modern pattern of intake has resulted in profound changes in feeding behavior. Shifts have occurred from diets high in fruits, vegetables, lean meats, and seafood to processed foods high in sodium and hydrogenated fats and low in fiber. These dietary changes have adversely affected dietary parameters known to be related to health, resulting in an increase in obesity and chronic disease, including cardiovascular disease (CVD), diabetes, and cancer. Some intervention trials using Paleolithic dietary patterns have shown promising results with favorable changes in CVD and diabetes risk factors. However, such benefits may be offset by disadvantages of the Paleolithic diet, which is low in vitamin D and calcium and high in fish potentially containing environmental toxins. More advantageous would be promotion of foods and food ingredients from our ancestral era that have been shown to possess health benefits in the form of functional foods. Many studies have investigated the health benefits of various functional food ingredients, including omega-3 fatty acids, polyphenols, fiber, and plant sterols. These bioactive compounds may help to prevent and reduce incidence of chronic diseases, which in turn could lead to health cost savings ranging from $2 to $3 billion per year as estimated by case studies using omega-3 and plant sterols as examples. Thus, public health benefits should result from promotion of the positive components of Paleolithic diets as functional foods.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Functional foods are usually not specifically focused on helping individuals to control their weight, but rather on enhancing health or reducing risk of disease through added nutrients.
“Functional foods are usually not specifically focused on helping individuals to control their weight, but rather on enhancing health or reducing risk of disease through added nutrients [11].”
From The association of demographic characteristics and food choice motives with the consumption of functional foods in emerging adults (2020) · cites this paper as [11]
Cites
Trumbo, P., Schlicker, S., Yates, A. A., & Poos, M. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90346-9 · Cited by 5,993 · see citing works
Diet, nutrition and the prevention of chronic diseases
Joint, W. (2002) · Medical Entomology and Zoology · Cited by 4,889 · see citing works
Who, J., & Diet, N. F. E. C. O. (2003) · World Health Organization eBooks · Cited by 3,425 · see citing works
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
de Lorgeril, M., Renaud, S., Salen, P., Monjaud, I., Mamelle, N., Martin, J. L., Guidollet, J., Touboul, P., & Delaye, J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92580-1 · Cited by 2,122 · see citing works
Cholesterol-lowering effects of dietary fiber: a meta-analysis
Brown, L., Rosner, B., Willett, W. W., & Sacks, F. M. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.1.30 · Cited by 1,857 · see citing works
The epidemiology of UV induced skin cancer
Armstrong, B. K., & Kricker, A. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00198-1 · Cited by 1,811 · see citing works
Tang, B. M., Eslick, G. D., Nowson, C., Smith, C., & Bensoussan, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61342-7 · Cited by 1,248 · see citing works
Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., Ryder, J. J., Hall, W. L., & Cassidy, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.38 · Cited by 1,097 · see citing works
Polyunsaturated fatty acids in the food chain in the United States
Kris-Etherton, P., Taylor, D. S., Yu-Poth, S., Huth, P., Moriarty, K., Fishell, V., Hargrove, R. L., Zhao, G., & Etherton, T. D. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.179s · Cited by 1,023 · see citing works
Green Tea Consumption and Mortality Due to Cardiovascular Disease, Cancer, and All Causes in Japan
Kuriyama, S., Shimazu, T., Ohmori, K., Kikuchi, N., Nakaya, N., Nishino, Y., Tsubono, Y., & Tsuji, I. (2006) · JAMA · doi:10.1001/jama.296.10.1255 · Cited by 763 · see citing works
The Effect of Polyphenols in Olive Oil on Heart Disease Risk Factors: A Randomized Trial
Covas, M.-I., Nyyssönen, K., Poulsen, H. E., Kaikkonen, J., Zunft, H.-J. F., Kiesewetter, H., Gaddi, A., de la Torre, R., Mursu, J., Bäumler, H., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-5-200609050-00006 · Cited by 758 · see citing works
Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review
Balk, E. M., Lichtenstein, A. H., Chung, M., Kupelnick, B., Chew, P., & Lau, J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.02.012 · Cited by 732 · see citing works
Fast foods, energy density and obesity: a possible mechanistic link
Prentice, A. M., & Jebb, S. A. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00117.x · Cited by 731 · see citing works
Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective
Eaton, S. B., Konner, M., & Shostak, M. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90113-1 · Cited by 703 · see citing works
Gebauer, S. K., Psota, T. L., Harris, W. S., & Kris-Etherton, P. M. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1526s · Cited by 642 · see citing works
Relative contributions of dietary sodium sources
Mattes, R. D., & Donnelly, D. (1991) · Journal of the American College of Nutrition · doi:10.1080/07315724.1991.10718167 · Cited by 595 · see citing works
Scientific Evidence of Interventions Using the Mediterranean Diet: A Systematic Review
Serra‐Majem, L., Román, B., & Estruch, R. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00232.x · Cited by 571 · see citing works
Singh, R. B., Niaz, M. A., Sharma, J. P., Kumar, R., Rastogi, V., & Moshiri, M. (1997) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1007757724505 · Cited by 536 · see citing works
Weststrate, J., & Meijer, G. W. (1998) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600559 · Cited by 536 · see citing works
Continuous Dose-Response Relationship of the LDL-Cholesterol–Lowering Effect of Phytosterol Intake
Demonty, I., Ras, R. T., van der Knaap, H. C. M., Duchateau, G. S. M. J. E., Meijer, L., Zock, P. L., Geleijnse, J. M., & Trautwein, E. A. (2008) · Journal of Nutrition · doi:10.3945/jn.108.095125 · Cited by 509 · see citing works
Geleijnse, J. M., Launer, L. J., van der Kuip, D. A. M., Albert Hofman, D., & Witteman, J. C. M. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.5.880 · Cited by 446 · see citing works
(2001) · CRC Press eBooks · doi:10.1201/9780203904220 · Cited by 436 · see citing works
Phytosterol Composition of Nuts and Seeds Commonly Consumed in the United States
Phillips, K. M., Ruggio, D. M., & Ashraf‐Khorassani, M. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051505h · Cited by 434 · see citing works
The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic
Cordain, L., Eaton, S., Brand-Miller, J. C., Mann, N. J., & Hill, K. R. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601353 · Cited by 418 · see citing works
n−3 Fatty acids and cardiovascular disease
Breslow, J. L. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1477s · Cited by 404 · see citing works
Olive oil and the cardiovascular system
Covas, M. I. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.010 · Cited by 401 · see citing works
Health and the rise of civilization
Crosby, A. W. (1990) · Choice Reviews Online · doi:10.5860/choice.27-2745 · Cited by 379 · see citing works
Phytosterols: Applications and recovery methods
Fernandes, P. C. D. B., & Cabral, J. M. S. (2006) · Bioresource Technology · doi:10.1016/j.biortech.2006.10.006 · Cited by 369 · see citing works
Abumweis, S., Barake, R., & Jones, P. (2008) · Food & Nutrition Research · doi:10.3402/fnr.v52i0.1811 · Cited by 369 · see citing works
Self-citationDoes Tea Affect Cardiovascular Disease? A Meta-Analysis
Peters, U. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.6.495 · Cited by 362 · see citing works
Plant sterols: factors affecting their efficacy and safety as functional food ingredients.
Berger, A., Jones, P. J. H., & AbuMweis, S. S. (2004) · Lipids in Health and Disease · doi:10.1186/1476-511x-3-5 · Cited by 341 · see citing works
Self-citationWesterterp‐Plantenga, M. S., Lejeune, M. P. G. M., & Kovacs, E. M. R. (2005) · Obesity Research · doi:10.1038/oby.2005.142 · Cited by 328 · see citing works
Analysis of phytosterols in foods
Lagarda, M. J., García‐Llatas, G., & FARRÉ, R. (2006) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2006.02.052 · Cited by 327 · see citing works
Review Paleolithic nutrition revisited: A twelve-year retrospective on its nature and implications
Eaton, S., Eaton, S. B., & Mj, K. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600389 · Cited by 295 · see citing works
Tea drinking and bone mineral density in older women
Hegarty, V., May, H. M., & Khaw, K. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.1003 · Cited by 293 · see citing works
O'Keefe, J. H., & Cordain, L. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.1.101 · Cited by 289 · see citing works
Green Tea Consumption and Prostate Cancer Risk in Japanese Men: A Prospective Study
Kurahashi, N., Sasazuki, S., Iwasaki, M., Inoue, M., & Shoichiro Tsugane for the JPHC Study Group (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm249 · Cited by 282 · see citing works
Trevisanato, S. I., & Kim, Y. I. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2000.tb01818.x · Cited by 277 · see citing works
Lindeberg, S., Jönsson, T., Granfeldt, Y., Borgstrand, E., Soffman, J., Sjöström, K., & Ahrén, B. (2007) · Diabetologia · doi:10.1007/s00125-007-0716-y · Cited by 273 · see citing works
Jones, P. J. H., Ntanios, F. Y., Raeini−Sarjaz, M., & Vanstone, C. A. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1144 · Cited by 243 · see citing works
Self-citationGreen tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies
Sun, C., Yuan, J., Koh, W., & Yu, M. C. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi276 · Cited by 232 · see citing works
β-Sitosterol activates Fas signaling in human breast cancer cells
Awad, A. B., Chinnam, M., Fink, C. S., & Bradford, P. G. (2007) · Phytomedicine · doi:10.1016/j.phymed.2007.01.003 · Cited by 211 · see citing works
Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial
Auvichayapat, P., Prapochanung, M., Tunkamnerdthai, O., Sripanidkulchai, B., Auvichayapat, N., Thinkhamrop, B., Kunhasura, S., Wongpratoom, S., Sinawat, S., & Hongprapas, P. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.009 · Cited by 210 · see citing works
Omega-3 fatty acids and cardiovascular disease
von Schacky, C. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3280127af0 · Cited by 207 · see citing works
The ancestral human diet: what was it and should it be a paradigm for contemporary nutrition?
Eaton, S. B. (2006) · Proceedings of The Nutrition Society · doi:10.1079/pns2005471 · Cited by 201 · see citing works
Dietary intake of selected minerals for the United States population: 1999-2000.
Ervin, R. B., Wright, J. D., Wang, C., & Kennedy‐Stephenson, J. (2004) · PubMed · Cited by 193 · see citing works
Dietary intake of ten key nutrients for public health, United States: 1999-2000.
Wright, J. D., Wang, C., Kennedy‐Stephenson, J., & Ervin, R. B. (2003) · PubMed · Cited by 184 · see citing works
Awad, A. B., Fink, C. S., Williams, H., et al. (2001) · European Journal of Cancer Prevention · doi:10.1097/00008469-200112000-00005 · Cited by 178 · see citing works
Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies
Sun, C., Yuan, J., Koh, W., & Yu, M. C. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl024 · Cited by 177 · see citing works
Effects of a short-term intervention with a paleolithic diet in healthy volunteers
Österdahl, M. F., Koctürk, T., Koochek, A., & Wändell, P. E. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602790 · Cited by 171 · see citing works
Effects of snacks on energy intake: An evolutionary perspective
de Graaf, C. (2006) · Appetite · doi:10.1016/j.appet.2006.02.007 · Cited by 163 · see citing works
Relationship among Habitual Tea Consumption, Percent Body Fat, and Body Fat Distribution
Wu, C., Lu, F., Chang, C., Chang, T., Wang, R., & Chang, C. (2003) · Obesity Research · doi:10.1038/oby.2003.149 · Cited by 160 · see citing works
Dietary intake of fats and fatty acids for the United States population: 1999-2000.
Ervin, R. B., Wright, J. D., Wang, C., & Kennedy‐Stephenson, J. (2004) · PubMed · Cited by 152 · see citing works
DeFilippis, A. P., & Sperling, L. S. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.03.051 · Cited by 147 · see citing works
Scientific Evidence of Interventions Using the Mediterranean Diet: A Systematic Review
Serra‐Majem, L., Román, B., & Estruch, R. (2006) · Nutrition Reviews · doi:10.1301/nr.2006.feb.s27-s47 · Cited by 147 · see citing works
Tea drinking is associated with benefits on bone density in older women
Devine, A., Hodgson, J. M., Dick, I. M., & Prince, R. L. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.1243 · Cited by 142 · see citing works
Phytosterols Reduce In Vitro Metastatic Ability of MDA-MB-231 Human Breast Cancer Cells
Awad, A. B., Williams, H., & Fink, C. S. (2001) · Nutrition and Cancer · doi:10.1207/s15327914nc402_12 · Cited by 138 · see citing works
Plant sterols in vegetables and fruits commonly consumed in Sweden
Normén, L., Johnsson, M., Andersson, H. A., et al. (1999) · European Journal of Nutrition · doi:10.1007/s003940050048 · Cited by 137 · see citing works
Davidson, M. H., Maki, K. C., Umporowicz, D. M., Ingram, K. A., Dicklin, M. R., Schaefer, E. J., Lane, R. W., McNamara, J. R., Ribaya‐Mercado, J. D., Perrone, G., et al. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719051 · Cited by 135 · see citing works
Epidemiological Evidence of Increased Bone Mineral Density in Habitual Tea Drinkers
Wu, C., Yang, Y., Yao, W., et al. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.9.1001 · Cited by 132 · see citing works
Hartweg, J., Farmer, A. A., Perera, R., Holman, R. R., & Neil, H. A. W. (2007) · Diabetologia · doi:10.1007/s00125-007-0695-z · Cited by 120 · see citing works
Vasculoprotective potential of olive oil components
Carluccio, M. A., Massaro, M., Scoditti, E., & Caterina, R. D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600305 · Cited by 114 · see citing works
Fish Consumption: Recommendations Versus Advisories, Can They Be Reconciled?
Smith, K. M., & Sahyoun, N. R. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00120.x · Cited by 103 · see citing works
Evolutionary Aspects of Diet: Old Genes, New Fuels
Eaton, S. B., & Cordain, L. (1997) · KARGER eBooks · doi:10.1159/000059599 · Cited by 89 · see citing works
Diet and cancer risk in Mediterranean countries: open issues
Vecchia, C. L., & Bosetti, C. (2006) · Public Health Nutrition · doi:10.1017/s1368980007668475 · Cited by 87 · see citing works
Jones, P. J. H., Howell, T., MacDougall, D. E., Feng, J. Y., & Parsons, W. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90041-5 · Cited by 67 · see citing works
Self-citationJönsson, T., Åhrén, B., Pacini, G., Sundler, F., Wierup, N., Steen, S., Sjöberg, T., Ugander, M., Frostegård, J., Göransson, L., et al. (2006) · Nutrition & Metabolism · doi:10.1186/1743-7075-3-39 · Cited by 62 · see citing works
Trichopoulou, A. (1995) · Cancer Causes & Control · doi:10.1007/bf00054153 · Cited by 57 · see citing works
The Nutritional Characteristics of a Contemporary Diet Based Upon Paleolithic Food Groups
Cordain, L. (2002) · Cited by 52 · see citing works
Carbohydrates and cancer: an overview of the epidemiological evidence
Key, T. J., & Spencer, E. A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602941 · Cited by 48 · see citing works
Cost-benefit analysis of a plant sterol containing low-fat margarine for cholesterol reduction
Gerber, A., Evers, T., Haverkamp, H., & Lauterbach, K. W. (2006) · The European Journal of Health Economics · doi:10.1007/s10198-006-0363-0 · Cited by 18 · see citing works
Abstracts of Original Communications 28 June–1 July 2005
Cassidy, A., Albertazzi, P., Lise Nielsen, I., et al. (2006) · Proceedings of The Nutrition Society · doi:10.1017/s0029665106005234 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary fibre modulates the gut microbiota
Cronin, P., Joyce, S. A., O’Toole, P. W., & O’Connor, E. M. (2021) · Nutrients · doi:10.3390/nu13051655 · Cited by 658 · see citing works
Garcia-Mantrana, I., Selma-Royo, M., Alcantara, C., & Collado, M. C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00890 · Cited by 574 · see citing works
Rethinking healthy eating in light of the gut microbiome
Armet, A. M., Deehan, E. C., O’Sullivan, A. F., Mota, J. F., Field, C. J., Prado, C. M., Lucey, A. J., & Walter, J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.016 · Cited by 252 · see citing works
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
Parker, J., O’Brien, C., Hawrelak, J., & Gersh, F. L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031336 · Cited by 114 · see citing works
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
parker, J., O'Brien, C., Hawrelak, J., & Gersh, F. (2021) · doi:10.20944/preprints202112.0088.v1 · Cited by 113 · see citing works
Ghaedi, E., Mohammadi, M., Mohammadi, H., Ramezani-Jolfaie, N., Malekzadeh, J., Hosseinzadeh, M., & Salehi-Abargouei, A. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz007 · Cited by 94 · see citing works
Vorage, L., Wiseman, N., Graca, J., & Harris, N. (2020) · Nutrients · doi:10.3390/nu12092582 · Cited by 39 · see citing works
Decoding the Foodome: Molecular Networks Connecting Diet and Health
Menichetti, G., Barabási, A.-L., & Loscalzo, J. (2024) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062322-030557 · Cited by 32 · see citing works
- Authors
- Jew, S., AbuMweis, S. S., & Jones, P. J. H.
- Affiliations
- McGill University (CA)
- Hashemite University (JO)
- University of Manitoba (CA)
- Corresponding author
- Jones, Peter J.H.
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2009-10
- Volume
- 12
- Issue
- 5
- Pages
- 925-934
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W2027600763
- Cited by
- 219
- References
- 72
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 13 · 2023: 20 · 2022: 21 · 2021: 17 · 2020: 11 · 2019: 13 · 2018: 10 · 2017: 16 · 2016: 7 · 2015: 18 · 2014: 18 · 2013: 18 · 2012: 7
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Consumer Attitudes and Food Labeling
- Keywords
- Paleolithic diet, functional foods, chronic disease prevention, dietary change, processed foods, obesity, cardiovascular disease, diabetes mellitus, cancer, omega-3 fatty acids, polyphenols, dietary fiber, phytosterols, bioactive compounds, health cost savings
- MeSH terms
- Chronic Disease, Diet, Humans, History, Ancient, Functional Food
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review