Effects of ID-HWS1000 on the Perception of Bowel Activity and Microbiome in Subjects with Functional Constipation: A Randomized, Double-Blind Placebo-Controlled Study
Abstract
During constipation, indigestible foods, such as probiotics, prebiotics, and dietary fiber, may improve the bowel environment and activity. In this randomized, double-blind, and placebo-controlled study, the effects of ID-HWS1000, composed of Lactobacillus and Bifidobacterium species, xylooligosaccharide, and dietary fiber, were evaluated to determine whether it improves the perception of bowel activity or cause changes in the gut microbiome. Thirty Korean adults with “functional constipation” according to the Rome III criteria were randomly assigned to the following groups: 20 in the ID-HWS1000 group and 10 in the placebo group. ID-HWS1000 or the placebo was consumed by the participants for 4 weeks. To assess the changes in the perception of bowel activity, clinical data and gut microbiome analyses were conducted before and after the experiment. There were significant differences between the groups in the response to 9 of the 12 survey questions (the number and duration of bowel movements, amount of feces, number of irritant bowel movements, number of times bowel movements felt incomplete, shape of the feces, amount of gas in the gut, discomfort after defecation, and discomfort owing to constipation) ( P < .05). There was a decrease in the proportion of Firmicutes ( Ruminococcaceae and Lachnospiraceae ) and an increase in Bacteroidetes ( Bacteroidaceae ) ( P < .05). Moreover, ID-HWS1000 directly improved the discomfort associated with bowel movements, decreased the proportion of Lachnospiraceae , and increased the proportion of Bacteroidaceae . These results confirmed that ID-HWS1000 improves the perception of bowel activity and exerts positive changes in individuals with functional constipation.
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The systematic review included 17 randomised controlled trials comprising 1256 adult patients with functional constipation.
“17 studies, comprising 1256 participants, were included with perfect agreements between two researchers (kappa statistic=0.797).”
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- Authors
- Kim, M. C., Lee, S., Park, J. K., Park, J., Lee, D., Park, J., Kim, B.-Y., Cho, M. S., Kim, T.-Y., Park, H. Y., Park, J. H., Bok, M. K., & Lim, H.
- Affiliations
- Ildong (South Korea) (KR)
- Kyung Hee University (KR)
- Microbiome Research Center, ChunLab, Inc., Seocho-gu, Korea.
- Corresponding author
- Lim, Hyunjung
- ORCID
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2021-08
- Volume
- 24
- Issue
- 8
- Pages
- 883-893
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W3195295690
- Cited by
- 18
- References
- 35
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 5
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- functional constipation, Lactobacillus, Bifidobacterium, xylooligosaccharides, dietary fiber, gut microbiota, Firmicutes, Bacteroidetes, Lachnospiraceae, Bacteroidaceae, probiotics, prebiotics
- MeSH terms
- Gastrointestinal Microbiome, Adult, Constipation, Defecation, Double-Blind Method, Humans, Perception, Treatment Outcome, Probiotics
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