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Cited by 145Gastrointestinal motility and disordersProbiotics and Fermented FoodsGut microbiota and health

Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation

BU, LING‐NAN, CHANG, MEI‐HWEI, NI, YEN‐HSUAN, CHEN, HUEY‐LING, CHENG, CHIA‐CHI·2007·Pediatrics International
DOI 10.1111/j.1442-200x.2007.02397.x
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Abstract

Background: The purpose of the present paper was to evaluate the efficacy of probiotics (Lactobacillus casei rhamnosus, Lcr35) for treating children with chronic constipation and to compare its effect with magnesium oxide (MgO) and placebo. Methods: This double‐blind placebo‐controlled, randomized study enrolled 45 children under 10 years old with chronic constipation. They were randomly assigned to receive Lcr35 (8 × 10 8 c.f.u./day; n = 18), MgO (50 mg/kg/day; n = 18), or placebo (n = 9) orally twice daily for 4 weeks. Lactulose use (1 mL/kg per day) was allowed when no stool passage for 3 days was noted. Glycerin enema was used only when no defecation was noted for >5 days or abdominal pain was suffered due to stool impaction. Bacterial cultures of stool were performed before and after treatment to evaluate the change of intestinal flora. Comparisons of the frequency of defecation, consistency of stool and the use of lactulose or enema during the period of treatment were made among the three groups. Results: The patients who received MgO or probiotics had a higher defecation frequency (P = 0.03), higher percentage of treatment success (P = 0.01), less use of glycerin enema (P = 0.04) and less hard stool (P = 0.01) than the placebo group. There was no significant difference between MgO and probiotic groups in the aforementioned comparisons. The first effect of MgO (second week) on constipation was slightly earlier than that of probiotic (second to third week). Abdominal pain occurred less frequently in the probiotic group than in both the MgO and the placebo groups (P = 0.03). There was no statistically significant difference among the three groups in the use of lactulose, episodes of fecal soiling, and change of appetite. No adverse effect was noted in probiotic and placebo groups. Only one patient in the MgO group suffered from mild diarrhea. Conclusion: Lcr35 was effective in treating children with chronic constipation. There is no statistically significant difference in efficacy between MgO and Lcr35, but less abdominal pain occurred when using Lcr35. Study with larger case number and longer follow up is needed in the future.

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Authors
BU, L., CHANG, M., NI, Y., CHEN, H., & CHENG, C.
Affiliations
Department of Health (TW)
Corresponding author
BU, LING‐NAN
ORCID
Venue
Pediatrics International
Publisher
Wiley
Published
2007-06-15
Volume
49
Issue
4
Pages
485-490
ISSN
  • 1328-8067 (ISSN-L)
  • 1442-200X
DOI
10.1111/j.1442-200x.2007.02397.x
OpenAlex
W2007740798
Cited by
145
References
27
Citations by year
2026: 2 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 4 · 2015: 11 · 2014: 14 · 2013: 9 · 2012: 7
FWCI
7.78
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Pediatrics International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
probiotics, chronic constipation, children, magnesium oxide, stool frequency, stool consistency, abdominal pain, fecal soiling, gut microbiota, glycerin enema, lactulose
MeSH terms
Child, Chronic Disease, Constipation, Double-Blind Method, Female, Humans, Lacticaseibacillus casei, Magnesium Oxide, Male, Probiotics

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