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Classification of Traumatic Brain Injury for Targeted Therapies
Open accessAbstract
The heterogeneity of traumatic brain injury (TBI) is considered one of the most significant barriers to finding effective therapeutic interventions. In October, 2007, the National Institute of Neurological Disorders and Stroke, with support from the Brain Injury Association of America, the Defense and Veterans Brain Injury Center, and the National Institute of Disability and Rehabilitation Research, convened a workshop to outline the steps needed to develop a reliable, efficient and valid classification system for TBI that could be used to link specific patterns of brain and neurovascular injury with appropriate therapeutic interventions. Currently, the Glasgow Coma Scale (GCS) is the primary selection criterion for inclusion in most TBI clinical trials. While the GCS is extremely useful in the clinical management and prognosis of TBI, it does not provide specific information about the pathophysiologic mechanisms which are responsible for neurological deficits and targeted by interventions. On the premise that brain injuries with similar pathoanatomic features are likely to share common pathophysiologic mechanisms, participants proposed that a new, multidimensional classification system should be developed for TBI clinical trials. It was agreed that preclinical models were vital in establishing pathophysiologic mechanisms relevant to specific pathoanatomic types of TBI and verifying that a given therapeutic approach improves outcome in these targeted TBI types. In a clinical trial, patients with the targeted pathoanatomic injury type would be selected using an initial diagnostic entry criterion, including their severity of injury. Coexisting brain injury types would be identified and multivariate prognostic modeling used for refinement of inclusion/exclusion criteria and patient stratification. Outcome assessment would utilize endpoints relevant to the targeted injury type. Advantages and disadvantages of currently available diagnostic, monitoring, and assessment tools were discussed. Recommendations were made for enhancing the utility of available or emerging tools in order to facilitate implementation of a pathoanatomic classification approach for clinical trials.
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“The secondary insult (ie, secondary damage, nonmechanical damage), characterizes consecutive neuropathological processes initiated at the moment of injury with delayed clinical presentation.For example, intracranial hypertension, hypoxia, hyponatremia, and cerebral ischemia refer to secondary insults, and these types of injury are variably sensitive to therapeutic interventions (94,97,111).”
From Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach (2015) · cites this paper as [111]
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“This strategy presents additional challenges as each animal model reflects a specific type of TBI and does not fully recapitulate primary and secondary damage evident in human TBI (45) resulting in restricted translation (46).”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [45]
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Citations
Cites
1 retracted
Demann, D., & Leisman, G. (1990) · International Journal of Neuroscience · doi:10.3109/00207459008986624 · Cited by 107
RetractedThe satisfaction with life scale
Diener, E., Emmons, R. A., Larsen, R. J., & Griffin, S. (1985) · Journal of Personality Assessment · doi:10.1207/s15327752jpa4901_13 · Cited by 31,768
ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS
Teasdale, G., & Jennett, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91639-0 · Cited by 13,215
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J., & Smith, P. G. (1977) · British Journal of Cancer · doi:10.1038/bjc.1977.1 · Cited by 8,285
Baker, S. P., O’Neill, B., Haddon, W. F., & Long, W. B. (1974) · PubMed · Cited by 7,946
ASSESSMENT OF OUTCOME AFTER SEVERE BRAIN DAMAGE A Practical Scale
JENNETT, B. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92830-5 · Cited by 7,501
Baker, S. P., O’Neill, B., Haddon, W. F., & Long, W. B. (1974) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-197403000-00001 · Cited by 7,326
International Classification of Functioning, Disability and Health
World Health Organization (2021) · PsycTESTS Dataset · doi:10.1037/t76403-000 · Cited by 3,751
International Classification of Functioning, Disability and Health
Chard, G. (2004) · British Journal of Occupational Therapy · doi:10.1177/030802260406700101 · Cited by 3,697
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J., & Smith, P. G. (1976) · British Journal of Cancer · doi:10.1038/bjc.1976.220 · Cited by 2,294
Fundamentals of Clinical Trials
Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2015) · doi:10.1007/978-3-319-18539-2 · Cited by 2,237
Diffuse axonal injury and traumatic coma in the primate
Gennarelli, T. A., Thibault, L. E., Adams, J. H., Graham, D. I., Thompson, C. J., & Marcincin, R. P. (1982) · Annals of Neurology · doi:10.1002/ana.410120611 · Cited by 1,528
Disability after severe head injury: observations on the use of the Glasgow Outcome Scale.
Jennett, B., Snoek, J. W., Bond, M., & Brooks, N. H. (1981) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.44.4.285 · Cited by 1,271
Validation of a new coma scale: The FOUR score
Wijdicks, E. F. M., Bamlet, W. R., Maramattom, B. V., Manno, E. M., & McClelland, R. L. (2005) · Annals of Neurology · doi:10.1002/ana.20611 · Cited by 1,121
Disability rating scale for severe head trauma: coma to community.
Rappaport, M. B., Hall, K., Hopkins, K. L., Belleza, T., & Cope, D. N. (1982) · PubMed · Cited by 1,093
Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases
Adams, J. H., Graham, D. I., Murray, L. S., & Scott, G. (1982) · Annals of Neurology · doi:10.1002/ana.410120610 · Cited by 950
Maas, A. I. R., Hukkelhoven, C. W. P. M., Marshall, L. F., & Steyerberg, E. W. (2005) · Neurosurgery · doi:10.1227/01.neu.0000186013.63046.6b · Cited by 943
Self-citationClinical trials in head injury
Narayan, R. K., Michel, M. E., Ansell, B., Baethmann, A., Biegon, A., Bracken, M. B., Bullock, M. R., Choi, S. C., Clifton, G. L., Contant, C. F., et al. (2002) · Journal of Neurotrauma · doi:10.1089/089771502753754037 · Cited by 913 · cited 6×
“Thus, injuries can be classified according to whether the head is struck or strikes an object (contact or “impact” loading) and/or the brain moves within the skull (noncontact or “inertial” loading).”
InfluentialSelf-citationFundamentals of Clinical Trials
Friedman, L. M., Furberg, C. D., & DeMets, D. L. (1998) · doi:10.1007/978-1-4757-2915-3 · Cited by 873
Military TBI During the Iraq and Afghanistan Wars
Warden, D. L. (2006) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200609000-00004 · Cited by 812
The diagnosis of head injury requires a classification based on computed axial tomography.
Lf, M., Sb, M., Klauber, M. R., van Berkum-Clark, M., Eisenberg, H. M., Jane, J. A., Luerssen, T. G., Marmarou, A., & Ma, F. (1992) · PubMed · Cited by 780
Champion, H. R., Sacco, W. J., Carnazzo, A. J., Copes, W. S., & Fouty, W. J. (1981) · Critical Care Medicine · doi:10.1097/00003246-198109000-00015 · Cited by 738
DIFFUSE DEGENERATION OF THE CEREBRAL WHITE MATTER IN SEVERE DEMENTIA FOLLOWING HEAD INJURY
Strich, S. J. (1956) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.19.3.163 · Cited by 728
Update of Neuropathology and Neurological Recovery After Traumatic Brain Injury
Povlishock, J. T., & Katz, D. I. (2005) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200501000-00008 · Cited by 676
BURGESS, P. W., ALDERMAN, N., FORBES, C., COSTELLO, A., M-A.COATES, L., DAWSON, D. R., ANDERSON, N. D., GILBERT, S. J., DUMONTHEIL, I., & CHANNON, S. (2006) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617706060310 · Cited by 663
Multivariable Prognostic Analysis in Traumatic Brain Injury: Results from The IMPACT Study
Murray, G. D., Butcher, I., McHugh, G. S., Lü, J., Mushkudiani, N. A., Maas, A. I. R., Marmarou, A., & Steyerberg, E. W. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0035 · Cited by 626
Self-citationInfluence of the type of intracranial lesion on outcome from severe head injury
Gennarelli, T. A., Spielman, G., Langfitt, T. W., Gildenberg, P. L., Harrington, T. R., Jane, J. A., Marshall, L. F., Miller, J. D., & Pitts, L. H. (1982) · Journal of neurosurgery · doi:10.3171/jns.1982.56.1.0026 · Cited by 582
Lateral Fluid Percussion Brain Injury: A 15-Year Review and Evaluation
Thompson, H. J., Lifshitz, J., Marklund, N., Grady, M. S., Graham, D. I., Hovda, D. A., & McIntosh, T. K. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.42 · Cited by 541
Improved confidence of outcome prediction in severe head injury
Narayan, R. K., Greenberg, R. P., Miller, J. D., Enas, G. G., Choi, S. C., Kishore, P. R. S., Selhorst, J. B., Lutz, H. A., & Becker, D. P. (1981) · Journal of neurosurgery · doi:10.3171/jns.1981.54.6.0751 · Cited by 539
Povlishock, J. T., & Christman, C. W. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.555 · Cited by 499
Levin, H. S., High, W. M., Goethe, K. E., Sisson, R. A., Overall, J. E., Rhoades, H. M., Eisenberg, H. M., Kalisky, Z., & Gary, H. E. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.2.183 · Cited by 483
Strich, S. J. (1961) · The Lancet · doi:10.1016/s0140-6736(61)92426-6 · Cited by 458
DIFFUSE BRAIN DAMAGE OF IMMEDIATE IMPACT TYPE
ADAMS, J. H., Mitchell, D. E., Graham, D. I., & Doyle, D. (1977) · Brain · doi:10.1093/brain/100.3.489 · Cited by 389
Kochanek, P. M., Berger, R. P., Margulies, S. S., & Jenkins, L. W. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0209 · Cited by 381
Prognosis and Clinical Trial Design in Traumatic Brain Injury: The IMPACT Study
Maas, A., Marmarou, A., Murray, G., Teasdale, G., & Steyerberg, E. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0024 · Cited by 366
Self-citationEcological validity of a simplified version of the multiple errands shopping test
ALDERMAN, N., BURGESS, P. W., KNIGHT, C., & HENMAN, C. (2003) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617703910046 · Cited by 337
Predictive value of Glasgow Coma Scale after brain trauma: change in trend over the past ten years.
Balestreri, M., Czosnyka, M., Chatfield, D. A., Steiner, L. A., Schmidt, E. A., Smielewski, P. S., MATTA, B. F., & Pickard, J. D. (2004) · PubMed Central · Cited by 303
Hukkelhoven, C. W. P. M., Steyerberg, E. W., Habbema, J. D. F., Farace, E., Marmarou, A., Murray, G. D., Marshall, L. F., & Maas, A. I. R. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.1025 · Cited by 302
Self-citationNeuropsychiatric Complications of Traumatic Brain Injury
Kim, E., Lauterbach, E. C., Reeve, A., Arciniegas, D. B., Coburn, K. L., Mendez, M. F., Rummans, T. A., & Coffey, E. C. (2007) · Journal of Neuropsychiatry · doi:10.1176/jnp.2007.19.2.106 · Cited by 297
(2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.9999 · Cited by 297
Brown, M., Dijkers, M., Gordon, W., Ashman, T., Charatz, H. J., & Cheng, Z. (2004) · The journal of head trauma rehabilitation · doi:10.1097/00001199-200411000-00004 · Cited by 281
WARTIME TRAUMATIC CEREBRAL VASOSPASM
Armonda, R. A., Bell, R. S., Vo, A. H., Ling, G. S. F., DeGraba, T. J., Crandall, B. M., Ecklund, J. M., & Campbell, W. W. (2006) · Neurosurgery · doi:10.1227/01.neu.0000249190.46033.94 · Cited by 276
Kennedy, J. E. (2007) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2006.12.0166 · Cited by 266
Head Injury: Recent Past, Present, and Future
Marshall, L. F. (2000) · Neurosurgery · doi:10.1097/00006123-200009000-00002 · Cited by 258
IMPACT Database of Traumatic Brain Injury: Design And Description
Marmarou, A., Lu, J., Butcher, I., McHugh, G. S., Mushkudiani, N. A., Murray, G. D., Steyerberg, E. W., & Maas, A. I. R. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0036 · Cited by 236
Self-citationvan Beek, J. G. M., Mushkudiani, N. A., Steyerberg, E. W., Butcher, I., McHugh, G. S., Lü, J., Marmarou, A., Murray, G. D., & Maas, A. I. R. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0034 · Cited by 235
Self-citationOertel, M., Boscardin, W. J., Obrist, W. D., Glenn, T. C., McArthur, D. L., Gravori, T., Lee, J. H., & Martin, N. A. (2005) · Journal of Neurosurgery · doi:10.3171/jns.2005.103.5.0812 · Cited by 227
Enhanced specificity of prognosis in severe head injury
Choi, S. C., Narayan, R. K., Anderson, R. L., & Ward, J. D. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.69.3.0381 · Cited by 198
Pineda, J., Lewis, S. B., Valadka, A. B., Papa, L., Hannay, H. J., Heaton, S. C., Demery, J. A., Liu, M. C., Aikman, J. M., Akle, V., et al. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.003789 · Cited by 189
Self-citationPrediction tree for severely head-injured patients
Choi, S. C., Muizelaar, J. P., Barnes, T. Y., Marmarou, A., Brooks, D., & Young, H. F. (1991) · Journal of neurosurgery · doi:10.3171/jns.1991.75.2.0251 · Cited by 179
Inaccurate Early Assessment of Neurological Severity in Head Injury
Stocchetti, N., Pagan, F., Calappi, E., Canavesi, K., Beretta, L., Citerio, G., Cormio, M., & Colombo, A. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1131 · Cited by 173
Clinical Trials in Traumatic Brain Injury: Lessons for the Future
DOPPENBERG, E. M. R., Choi, S. C., & Bullock, R. M. (2003) · Journal of Neurosurgical Anesthesiology · doi:10.1097/00008506-200401000-00019 · Cited by 140
Self-citationControlled Cortical Impact in Swine: Pathophysiology and Biomechanics
Manley, G. T., Rosenthal, G., Lam, M. M., Morabito, D. J., Yan, D., Derugin, N., Bollen, A. W., Knudson, M. M., & Panter, S. S. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.128 · Cited by 126
Self-citationWorkshop on Animal Models of Traumatic Brain Injury
Povlishock, J. T., Hayes, R. L., Michel, M. E., & McIntosh, T. K. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.723 · Cited by 114
Statler, K. D., Jenkins, L. W., Dixon, C. E., Clark, R. S. B., Marion, D. W., & Kochanek, P. M. (2001) · Journal of Neurotrauma · doi:10.1089/089771501317095232 · Cited by 113
Neuropathology of the vegetative state after head injury
Graham, D. I., Adams, J., Murray, L. S., & Jennett, B. (2005) · Neuropsychological Rehabilitation · doi:10.1080/09602010443000452 · Cited by 106
The status of the Glasgow Coma Scale
Gabbe, B. J., Cameron, P. A., & Finch, C. F. (2003) · Emergency Medicine Australasia · doi:10.1046/j.1442-2026.2003.00474.x · Cited by 98
MIKOLAJCZYK, P., & PASZKOWSKI, B. (1964) · Elsevier eBooks · doi:10.1016/b978-1-4832-1342-2.50020-8 · Cited by 94
Die akuten traumatischen Hirnstammsch�den
Gerstenbrand, F., & L�cking, C. H. (1970) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00342662 · Cited by 87
Kim, E., Lauterbach, E. C., Reeve, A., Arciniegas, D. B., Coburn, K. L., Mendez, M. F., Rummans, T. A., & Coffey, E. C. (2007) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.19.2.106 · Cited by 74
Report on the meeting of the W.F.N.S. neuro-traumatology committee, Brussels, 19–23 September 1976
Brihaye, J., Frowein, R. A., Lindgren, S., Loew, F., & Stroobandt, G. (1978) · Acta Neurochirurgica · doi:10.1007/bf01773126 · Cited by 71
The BrainIT group: concept and core dataset definition
Piper, I., Citerio, G., Chambers, I. R., Contant, C., Enblad, P., Fiddes, H., Howells, T., Kiening, K. L., Nilsson, P., & Yau, Y. H. (2003) · Acta Neurochirurgica · doi:10.1007/s00701-003-0066-6 · Cited by 59
Merritt, B. K., & Fisher, A. G. (2003) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(03)00483-0 · Cited by 48
Introduction to Neuropathology
(1950) · JAMA · doi:10.1001/jama.1950.02910520072046 · Cited by 47
Bouwens, S., Heugten, C. M. V., Aalten, P., Wolfs, C. A. G., Baarends, E. M., van Menxel, D. A. J., & Verhey, F. R. J. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000111694 · Cited by 44
Gallagher, C. N., Hutchinson, P. J., & Pickard, J. D. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32821b987b · Cited by 43
Continuous monitoring of intracranial pressure in severe closed head injury without mass lesions.
Fleischer, A. S., Ns, P., & Gt, T. (1976) · PubMed · Cited by 43
Improving quality of ADL performance after rehabilitation among people with acquired brain injury
Wæhrens, E. E., & Fisher, A. G. (2007) · Scandinavian Journal of Occupational Therapy · doi:10.1080/11038120601182974 · Cited by 32
An Introduction to Neuropathology
Ironside, J. W. (1994) · Histopathology · doi:10.1111/j.1365-2559.1994.tb01383.x · Cited by 24
Mayo-Portland Adaptability Inventory-4
Malec, J. F., & Lezak, M. D. (2008) · PsycTESTS Dataset · doi:10.1037/t29117-000 · Cited by 22
BrainIT: a trans-national head injury monitoring research network
Chambers, I. R., Barnes, J., Piper, I., Citerio, G., Enblad, P., Howells, T. P., Kiening, K. L., Mattern, J., Nilsson, P., Ragauskas, A., et al. (2006) · Springer eBooks · doi:10.1007/3-211-30714-1_2 · Cited by 7
Research works printed but not linked: 1
- Guidelines for the management of severe traumatic brain injury. 2007. J. Neurotrauma, 24,Suppl 1:S1–106.
Cited by
Sorted by citations
Traumatic brain injury: progress and challenges in prevention, clinical care, and research
Maas, A. I. R., Menon, D. K., Manley, G. T., Abrams, M. B., Åkerlund, C. A. I., Anđelić, N., Aries, M. J. H., Bashford, T., Bell, M. J., Bodien, Y. G., et al. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00309-x · Cited by 1,737
Self-citationAnimal models of traumatic brain injury
Xiong, Y., Mahmood, A., & Chopp, M. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3407 · Cited by 1,456
Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury
Shlosberg, D., Benifla, M., Kaufer, D., & Friedman, A. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.74 · Cited by 897
Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets
Ng, S. Y., & Lee, A. Y. W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00528 · Cited by 906
Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift
Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799
Metadata
- Authors
- Saatman, K. E., Duhaime, A.-C., Bullock, R., Maas, A. I. R., Valadka, A., & Manley, G. T.
- Affiliations
- University of Kentucky (US)
- Dartmouth–Hitchcock Medical Center (US)
- University of Miami (US)
- University of Antwerp (BE)
- The University of Texas Health Science Center at Houston (US)
- University of California, San Francisco (US)
- Corresponding author
- Manley, Geoffrey T.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2008-07
- Volume
- 25
- Issue
- 7
- Pages
- 719-738
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- PMC
- PMC2721779
- OpenAlex
- W2050800676
- Cited by
- 1,141
- References
- 70
- Citations by year
- 2026: 25 · 2025: 62 · 2024: 63 · 2023: 45 · 2022: 57 · 2021: 63 · 2020: 74 · 2019: 69 · 2018: 87 · 2017: 79 · 2016: 64 · 2015: 102 · 2014: 59 · 2013: 62 · 2012: 70
- FWCI
- 32.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neurotrauma (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- National Institute on Disability and Rehabilitation Research
- National Institute of Neurological Disorders and Stroke (P01NS038660, R01NS042691, R01NS050173, P01NS058484, R01NS045131)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD045364)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
- Keywords
- traumatic brain injury, targeted therapy, pathophysiological mechanisms, Glasgow Coma Scale, clinical trial design, patient selection criteria, patient stratification, prognostic model, preclinical models, outcome measurement, neurovascular injury
- MeSH terms
- Animals, Brain Injuries, Clinical Trials as Topic, Data Interpretation, Statistical, Diagnosis, Differential, Diagnostic Imaging, Disability Evaluation, Disease Models, Animal, Humans, Trauma Severity Indices, Glasgow Coma Scale, Endpoint Determination
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