Biomarkers for Prediction of Bovine Respiratory Disease Outcome
Abstract
Fatal bovine respiratory disease (BRD) is frequently the result of a primary viral and a secondary bacterial respiratory infection. In cattle, BRD causes more than half of feedlot deaths and has a major impact on financial losses in the cattle industry in North America. It is, therefore, very important to understand the mechanism of this complex disease process as well to predict and identify BRD susceptible cattle to enhance treatment efficacy. We recently established the value of using combinatorial omics approaches to identify candidate biomarkers associated with stress responses, a factor that can increase the severity of BRD. The objective of the present investigation was to experimentally recreate fatal BRD and to use a combinatorial analysis of proteomic, metabonomic, and elemental profiles in serum samples to determine if multimethod analysis of these biomarkers could predict disease outcome. The proteomic studies revealed that changes in the serum proteome were significant on day 4 postviral infection when compared to preinfection (day 0) serum samples. Proteomic studies identified a group of acute phase proteins (haptoglobin and apolipoprotein AI), which could be linked to a primary viral respiratory infection, but there was no significant association observed with fatal BRD. In contrast, metabonomic and elemental analyses identified candidate biomarkers for viral infection (glucose, LDL, valine, phosphorous, and iron) and disease outcome (lactate, glucose, iron). W…
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Complementary diagnostic methods such as laboratory testing, imaging, molecular diagnostics, and biomarker tracking can offer additional support but are usually prohibitively expensive.
“Complementary diagnostic methods such as laboratory testing, imaging, molecular diagnostics, and biomarker tracking can offer additional support but are usually prohibitively expensive [26,27,28,29,30,31,32,33,34,35].”
From Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview (2024) · cites this paper as [26]
A recent study found a positive association between post-viral infection increases in glucose levels and extended survival rates (p < 0.05).
“A recent study found a positive association between post-viral infection increases in glucose levels and extended survival rates (p < 0.05) [26].”
From Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview (2024) · cites this paper as [26]
Initial lactate concentrations at the time of BRD diagnosis did not directly predict mortality in natural cases.
“In contrast, initial lactate concentrations at the time of BRD diagnosis did not directly predict mortality in natural cases.”
From Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview (2024) · cites this paper as [26]
An incremental increase in lactate levels by 1-log (measured on days 3, 6, 9, and 15 following initial treatment) significantly heightened the mortality risk by a factor of 36.5 (95% CI: 3.5-381.6).
“However, an incremental increase in lactate levels by 1-log (measured on days 3, 6, 9, and 15 following initial treatment) significantly heightened the mortality risk by a factor of 36.5 (95% CI: 3.5–381.6) [26].”
From Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview (2024) · cites this paper as [26]
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- Authors
- Aich, P., Babiuk, L. A., Potter, A. A., & Griebel, P.
- Affiliations
- University of Saskatchewan (CA)
- University of Alberta (CA)
- Venue
- OMICS: A Journal of Integrative Biology
- Publisher
- SAGE Publications
- Published
- 2009-06
- Volume
- 13
- Issue
- 3
- Pages
- 199-209
- ISSN
- 1536-2310 (ISSN-L)
- 1557-8100
- OpenAlex
- W2009062850
- Cited by
- 46
- References
- 37
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 3 · 2018: 4 · 2017: 3 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- OMICS A Journal of Integrative Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Saskatchewan
- Ministry of Agriculture - Saskatchewan
- Canada Research Chairs
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- bovine respiratory disease, disease outcome prediction, serum biomarkers, acute phase proteins, haptoglobin, apolipoprotein A-I, serum proteome, serum metabolome, feedlot cattle, stress response, mortality prediction
- MeSH terms
- Animals, Cattle, Cattle Diseases, Disease Susceptibility, Prognosis, Biomarkers, Survival Rate, Multivariate Analysis, Proteome, Bovine Respiratory Disease Complex
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