Cited by 120Bone Tissue Engineering MaterialsSilk-based biomaterials and applicationsElectrospun Nanofibers in Biomedical Applications

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Electrospun Silk Fibroin Scaffolds with Macropores for Bone Regeneration: An In Vitro and In Vivo Study

Park, Sook Young, Ki, Chang Seok, Park, Young Hwan, Jung, Hong Moon, Woo, Kyung Mi, Kim, Hyun Jeong·2010·Tissue Engineering Part A

DOI 10.1089/ten.tea.2009.0328

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Abstract

We developed three-dimensional electrospun silk fibroin (ESF) scaffolds with controllable pore size. The purpose of this study was to evaluate ESF scaffolds with pores (P-ESF) for bone regeneration via in vitro and in vivo studies, with a comparison to a commercially available porous three-dimensional polylactic acid (PLA) scaffold. P-ESF supported significantly higher proliferation and alkaline phosphatase activity of osteoblasts than PLA in vitro (p < 0.05). Moreover, higher expression levels of activated adhesion-related proteins, including focal adhesion kinase, were observed in the P-ESF than in PLA, as confirmed by western blot analyses. Microcomputed tomography revealed that 78.30% of the original bone volume was attained in the P-ESF implantation group at 7 weeks after critical bone defect formation in rat calvaria. Comparatively, the PLA implantation group showed only 49.31%. Histological evaluation also showed new bone tissue formation upon P-ESF implantation. Taken together, the P-ESF scaffold may be a good bone substitute for bone regeneration.

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Authors: Park, S. Y., Ki, C. S., Park, Y. H., Jung, H. M., Woo, K. M., & Kim, H. J.
Affiliations: Seoul National University (KR)
Corresponding author: Kim, Hyun Jeong
ORCID: Ki, Chang Seok
Park, Young Hwan
Woo, Kyung Mi
Kim, Hyun Jeong
Venue: Tissue Engineering Part A
Publisher: SAGE Publications
Published: 2010-04
Volume: 16
Issue: 4
Pages: 1271-1279
ISSN: 1937-3341 (ISSN-L)
1937-335X
DOI: 10.1089/ten.tea.2009.0328
OpenAlex: W2066288600
Cited by: 120
References: 44
Citations by year: 2026: 2 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 12 · 2015: 10 · 2014: 11 · 2013: 5 · 2012: 7
FWCI: 3.60
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Tissue Engineering Part A (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: Korea Science and Engineering Foundation
European Social Fund
Topics: Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords: silk fibroin, electrospun scaffolds, macropores, bone regeneration, bone substitutes, polylactic acid scaffolds, osteoblast proliferation, alkaline phosphatase activity, focal adhesion kinase, critical-size calvarial defect, new bone formation, pore size control
MeSH terms: Animals, Biocompatible Materials, Bone Regeneration, Fibroins, Male, Materials Testing, Microscopy, Electron, Scanning, Polyesters, Polymers, Radiography, Bombyx, Skull, 3T3 Cells, Rats, Sprague-Dawley, Lactic Acid, Tissue Engineering, Mice, Rats, Tissue Scaffolds

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Electrospun Silk Fibroin Scaffolds with Macropores for Bone Regeneration: An In Vitro and In Vivo Study

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