Scaffolding in tissue engineering: general approaches and tissue-specific considerations
Open accessAbstract
Scaffolds represent important components for tissue engineering. However, researchers often encounter an enormous variety of choices when selecting scaffolds for tissue engineering. This paper aims to review the functions of scaffolds and the major scaffolding approaches as important guidelines for selecting scaffolds and discuss the tissue-specific considerations for scaffolding, using intervertebral disc as an example.
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dLECM preserves the complex network of collagen, fibronectin, growth factors, and other bioactive molecules, keeping the biological blueprint of the liver intact.
“By stripping away cells while preserving the complex network of collagen, fibronectin, growth factors, and other bioactive molecules, dLECM keeps the “biological blueprint” of the liver intact [6,7].”
From From scaffold to function: A systematic review on dLECM-based hydrogels for liver tissue engineering — Fabrication, properties, and translational applications (2026) · cites this paper as [7]
The 'Scaffolding approaches in tissue engineering' section says decellularization removes cellular components while preserving ECM components, and that growth factors may remain in the matrix. The 'Analogous functions of scaffolds and extracellular matrix' section describes collagen and fibronectin as ECM constituents or cues. Neither section establishes that decellularized liver ECM preserves those components specifically or keeps the liver’s biological blueprint intact; the paper also notes that decellularization must be optimized to minimize disturbance to ECM composition. (LLM, conf=0.86)
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- Authors
- Chan, B. P., & Leong, K. W.
- Affiliations
- University of Hong Kong (HK)
- Duke University (US)
- Corresponding author
- Chan, B. P.
- Venue
- European Spine Journal
- Published
- 2008-11-13
- Volume
- 17
- Issue
- S4
- Pages
- 467-479
- ISSN
- 0940-6719 (ISSN-L)
- 1432-0932
- PMC
- PMC2587658
- OpenAlex
- W1974193257
- Semantic Scholar
- f93c21364846ebca373c4640d39143db1a99fbef
- Cited by
- 1,708
- References
- 134
- Citations by year
- 2026: 76 · 2025: 158 · 2024: 168 · 2023: 158 · 2022: 143 · 2021: 140 · 2020: 108 · 2019: 138 · 2018: 125 · 2017: 139 · 2016: 98 · 2015: 78 · 2014: 76 · 2013: 48 · 2012: 17
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Spine Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Innovation and Technology Commission
- Hong Kong Government
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (R01EB003447, EB003447)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spine and Intervertebral Disc Pathology
- Keywords
- scaffolds, tissue engineering, intervertebral disc, cartilage regeneration
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Humans, Intervertebral Disc, Intervertebral Disc Displacement, Regeneration, Chondrocytes, Tissue Engineering, Intercellular Signaling Peptides and Proteins, Tissue Scaffolds
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