The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A Customized Self-Assembling Peptide Hydrogel for Dental Pulp Tissue Engineering
Open accessAbstract
Root canal therapy is common practice in dentistry. During this procedure, the inflamed or necrotic dental pulp is removed and replaced with a synthetic material. However, recent research provides evidence that engineering of dental pulp and dentin is possible by using biologically driven approaches. As tissue engineering strategies hold the promise to soon supersede conventional root canal treatment, there is a need for customized scaffolds for stem cell delivery or recruitment. We hypothesize that the incorporation of dental pulp-derived stem cells with bioactive factors into such a scaffold can promote cell proliferation, differentiation, and angiogenesis. In this study, we used a cell adhesive, enzyme-cleavable hydrogel made from self-assembling peptide nanofibers to encapsulate dental pulp stem cells. The growth factors (GFs) fibroblast growth factor basic, transforming growth factor β1, and vascular endothelial growth factor were incorporated into the hydrogel via heparin binding. Release profiles were established, and the influence of GFs on cell morphology and proliferation was assessed to confirm their bioactivity after binding and subsequent release. Cell morphology and spreading in three-dimensional cultures were visualized by using cell tracker and histologic stains. Subcutaneous transplantation of the hydrogel within dentin cylinders into immunocompromised mice led to the formation of a vascularized soft connective tissue similar to dental pulp. These data support the use of this novel biomaterial as a highly promising candidate for future treatment concepts in regenerative endodontics.
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Cites
Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
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Investigation of multipotent postnatal stem cells from human periodontal ligament
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SHED: Stem cells from human exfoliated deciduous teeth
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Factors affecting the long-term results of endodontic treatment
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Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth
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Dental Pulp Tissue Engineering with Stem Cells from Exfoliated Deciduous Teeth
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Cited by
Amino Acids and Peptide‐Based Supramolecular Hydrogels for Three‐Dimensional Cell Culture
Dou, X., & Feng, C. (2017) · Advanced Materials · doi:10.1002/adma.201604062 · Cited by 355
Dentin Conditioning Codetermines Cell Fate in Regenerative Endodontics
Galler, K. M., D’Souza, R. N., Federlin, M., Cavender, A. C., Hartgerink, J. D., Hecker, S., & Schmalz, G. (2011) · Journal of Endodontics · doi:10.1016/j.joen.2011.08.027 · Cited by 323
Self-citationExtracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering
Rowley, A. T., Nagalla, R. R., Wang, S., & Liu, W. F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801578 · Cited by 193
Peptidic Biomaterials: From Self-Assembling to Regenerative Medicine
Pugliese, R., & Gelain, F. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.09.004 · Cited by 133
Deciphering Reparative Processes in the Inflamed Dental Pulp
El karim, I. A., Cooper, P. R., About, I., Tomson, P. L., Lundy, F. T., & Duncan, H. F. (2021) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2021.651219 · Cited by 46
Metadata
- Authors
- Galler, K. M., Hartgerink, J. D., Cavender, A. C., Schmalz, G., & D'Souza, R. N.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2012-01
- Volume
- 18
- Issue
- 1-2
- Pages
- 176-184
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- OpenAlex
- W1972609083
- Cited by
- 276
- References
- 27
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- green
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