Cited by 156Cellular transport and secretionAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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The R-SNARE Endobrevin/VAMP-8 Mediates Homotypic Fusion of Early Endosomes and Late Endosomes

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Antonin, Wolfram, Holroyd, Claudia, Tikkanen, Ritva, Höning, Stefan, Jahn, Reinhard·2000·Molecular Biology of the Cell

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Abstract

Endobrevin/VAMP-8 is an R-SNARE localized to endosomes, but it is unknown in which intracellular fusion step it operates. Using subcellular fractionation and quantitative immunogold electron microscopy, we found that endobrevin/VAMP-8 is present on all membranes known to communicate with early endosomes, including the plasma membrane, clathrin-coated pits, late endosomes, and membranes of thetrans-Golgi network. Affinity-purified antibodies that block the ability of endobrevin/VAMP-8 to form SNARE core complexes potently inhibit homotypic fusion of both early and late endosomes in vitro. Fab fragments were as active as intact immunoglobulin Gs. Recombinant endobrevin/VAMP-8 inhibited both fusion reactions with similar potency. We conclude that endobrevin/VAMP-8 operates as an R-SNARE in the homotypic fusion of early and late endosomes.

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Authors: Antonin, W., Holroyd, C., Tikkanen, R., Höning, S., & Jahn, R.
Affiliations: Max Planck Institute for Biophysical Chemistry (DE)
University of Bonn (DE)
University of Göttingen (DE)
ORCID: Antonin, Wolfram
Tikkanen, Ritva
Höning, Stefan
Jahn, Reinhard
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 2000-10
Volume: 11
Issue: 10
Pages: 3289-3298
ISSN: 1059-1524 (ISSN-L)
1939-4586
DOI: 10.1091/mbc.11.10.3289
PMC: PMC14992
OpenAlex: W2148157392
Cited by: 156
References: 60
Citations by year: 2026: 3 · 2025: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 5 · 2012: 14
FWCI: 1.92
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Molecular Biology of the Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
GRO (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: National Science Foundation
Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: R-SNARE, homotypic fusion, early endosomes, late endosomes, membrane trafficking, clathrin-coated pits, trans-Golgi network, endosomal membrane fusion
MeSH terms: Animals, Cell Fractionation, Cell Membrane, Cell-Free System, Coated Pits, Cell-Membrane, Membrane Fusion, Membrane Proteins, Endosomes, Synaptophysin, trans-Golgi Network, Vesicular Transport Proteins, SNARE Proteins, R-SNARE Proteins, Qa-SNARE Proteins, Rats

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The R-SNARE Endobrevin/VAMP-8 Mediates Homotypic Fusion of Early Endosomes and Late Endosomes

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