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A Novel Endocytic Recycling Signal Distinguishes Biological Responses of Trk Neurotrophin Receptors
Abstract
Endocytic trafficking of signaling receptors to alternate intracellular pathways has been shown to lead to diverse biological consequences. In this study, we report that two neurotrophin receptors (tropomyosin-related kinase TrkA and TrkB) traverse divergent endocytic pathways after binding to their respective ligands (nerve growth factor and brain-derived neurotrophic factor). We provide evidence that TrkA receptors in neurosecretory cells and neurons predominantly recycle back to the cell surface in a ligand-dependent manner. We have identified a specific sequence in the TrkA juxtamembrane region, which is distinct from that in TrkB receptors, and is both necessary and sufficient for rapid recycling of internalized receptors. Conversely, TrkB receptors are predominantly sorted to the degradative pathway. Transplantation of the TrkA recycling sequence into TrkB receptors reroutes the TrkB receptor to the recycling pathway. Finally, we link these divergent trafficking pathways to alternate biological responses. On prolonged neurotrophin treatment, TrkA receptors produce prolonged activation of phosphatidylinositol 3-kinase/Akt signaling as well as survival responses, compared with TrkB receptors. These results indicate that TrkA receptors, which predominantly recycle in signal-dependent manner, have unique biological properties dictated by its specific endocytic trafficking itinerary.
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TrkB receptors are degraded via lysosomes in a BDNF-dependent manner in cell lines such as PC12 cells and in primary neuronal cultures.
“It has been established that TrkB receptors are degraded via lysosomes in a BDNF-dependent manner in cell lines such as PC12 cells and in primary neuronal cultures (Chen et al., 2005;Huang et al., 2009).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Chen et al., 2005
BDNF can efficiently drive TrkB receptor internalization, and endocytosed TrkB receptors can either traffic to lysosomes for degradation or recycle back to the plasma membrane.
“BDNF can efficiently drive TrkB receptor internalization and endocytosed TrkB receptors could either traffic to lysosomes for degradation or recycle back to the plasma membrane (Chen et al., 2005;Huang et al., 2009).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Chen et al., 2005
Upon internalization, TrkB receptors are sorted in early endosomes either to a specialized recycling endosome compartment for reinsertion to the plasma membrane or to late endosomes and lysosomes for degradation.
“Upon internalization, TrkB receptors are sorted in early endosomes either to a specialized recycling endosome compartment for reinsertion to the plasma membrane or to late endosomes and lysosomes for degradation (Chen et al., 2005).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Chen et al., 2005
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Citations
Cites
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
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Metadata
- Authors
- Chen, Z.-Y., Ieraci, A., Tanowitz, M., & Lee, F. S.
- Affiliations
- Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021
- Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143
- Venue
- Molecular Biology of the Cell
- Published
- 2005-12
- Volume
- 16
- Issue
- 12
- Pages
- 5761-5772
- ISSN
- 1059-1524
- 1939-4586
- Cited by
- 98
- References
- 4
- Language
- en
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