Cited by 204Fungal and yeast genetics researchBacterial Genetics and BiotechnologyProtein Kinase Regulation and GTPase Signaling

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The Sequential Activation of the Yeast HOG and SLT2 Pathways Is Required for Cell Survival to Cell Wall Stress

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Bermejo, Clara, Rodríguez, Estefanía, García, Raúl, Rodríguez-Peña, Jose M., Rodríguez de la Concepción, María L., Rivas, Carmen, Arias, Patricia, Nombela, César, Posas, Francesc, Arroyo, Javier·2008·Molecular Biology of the Cell

DOI 10.1091/mbc.e07-08-0742PMC PMC2262984

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Abstract

Yeast mitogen-activated protein kinase (MAPK) signaling pathways transduce external stimuli into cellular responses very precisely. The MAPKs Slt2/Mpk1 and Hog1 regulate transcriptional responses of adaptation to cell wall and osmotic stresses, respectively. Unexpectedly, we observe that the activation of a cell wall integrity (CWI) response to the cell wall damage caused by zymolyase (β-1,3 glucanase) requires both the HOG and SLT2 pathways. Zymolyase activates both MAPKs and Slt2 activation depends on the Sho1 branch of the HOG pathway under these conditions. Moreover, adaptation to zymolyase requires essential components of the CWI pathway, namely the redundant MAPKKs Mkk1/Mkk2, the MAPKKK Bck1, and Pkc1, but it does not require upstream elements, including the sensors and the guanine nucleotide exchange factors of this pathway. In addition, the transcriptional activation of genes involved in adaptation to cell wall stress, like CRH1, depends on the transcriptional factor Rlm1 regulated by Slt2, but not on the transcription factors regulated by Hog1. Consistent with these findings, both MAPK pathways are essential for cell survival under these circumstances because mutant strains deficient in different components of both pathways are hypersensitive to zymolyase. Thus, a sequential activation of two MAPK pathways is required for cellular adaptation to cell wall damage.

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Authors: Bermejo, C., Rodríguez, E., García, R., Rodríguez-Peña, J. M., Rodríguez de la Concepción, M. L., Rivas, C., Arias, P., Nombela, C., Posas, F., & Arroyo, J.
Affiliations: Universidad Complutense de Madrid (ES)
*Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain; and
Cell Signalling Unit, Department de Ciènces Experimentals I de la Salut, Universitat Pompeu Fabra (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), E-08003 Barcelona, Spain
Universitat Pompeu Fabra (ES)
ORCID: Bermejo, Clara
Rodríguez, Estefanía
García, Raúl
Rivas, Carmen
Nombela, César
Posas, Francesc
Arroyo, Javier
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 2008-03
Volume: 19
Issue: 3
Pages: 1113-1124
ISSN: 1059-1524 (ISSN-L)
1939-4586
DOI: 10.1091/mbc.e07-08-0742
PMC: PMC2262984
OpenAlex: W2103491947
Cited by: 204
References: 60
Citations by year: 2026: 11 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 7 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 16 · 2015: 18 · 2014: 17 · 2013: 7 · 2012: 15
FWCI: 7.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Biology of the Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Johns Hopkins University
Ministerio de Economía y Competitividad
Universitat de Lleida
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: HOG pathway, cell wall integrity, MAPK signaling, zymolyase, β-1,3-glucanase, cell wall stress, osmotic stress, Sho1, PKC1, Rlm1, Saccharomyces cerevisiae, stress adaptation, cell survival
MeSH terms: Adaptation, Physiological, Cell Wall, Enzyme Activation, Hydrolases, Mutation, Phosphorylation, Saccharomyces cerevisiae, Transcriptional Activation, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Saccharomyces cerevisiae Proteins, Microbial Viability

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The Sequential Activation of the Yeast HOG and SLT2 Pathways Is Required for Cell Survival to Cell Wall Stress

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