Our paths might cross: the role of the fungal cell wall integrity pathway in stress response and cross talk with other stress response pathways

Fuchs, Beth Burgwyn; Mylonakis, Eleftherios

doi:10.1128/ec.00193-09

Cited by 266Fungal and yeast genetics researchAntifungal resistance and susceptibilityBacterial Genetics and Biotechnology

Our paths might cross: the role of the fungal cell wall integrity pathway in stress response and cross talk with other stress response pathways

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Fuchs, Beth Burgwyn, Mylonakis, Eleftherios·2009·Eukaryotic Cell

DOI 10.1128/ec.00193-09PMC PMC2772411

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Abstract

Fungi occupy diverse environments and are subjected to many extreme conditions. Among the stressful conditions faced by fungi are pH changes, osmotic changes, thermal changes, oxide radicals, nutrient deprivation, and exposure to chemicals. These adversities can be found either in the environment or in animal and human hosts. The cell wall integrity (CWI) pathway provides a means to fortify and repair damages to the cell wall in order to withstand stressful environments. The CWI pathway in comprised of cell wall stress sensors that lead to activation of a mitogen-activated protein kinase (MAPK) cascade. Signaling through the MAPK cascade leads to expression of transcription factors that facilitate biosynthesis of cell wall components and actin organization. Given the relatively limited number of components of the CWI pathway and the very diverse stimuli, there must be a means of expanding the pathway. To manage the diverse stress conditions, the CWI pathway cross talks with other pathways or proteins, and these cross talk events enhance the signaling capabilities of the CWI pathway. Lateral influences that facilitate maintaining the cell wall under stress conditions are TOR signaling, calcineurin signaling, the high-osmolarity glycerol pathway, the cyclic AMP-protein kinase A pathway, and additional proteins. In this article, we highlight several of the cross talk events that have been described for Saccharomyces cerevisiae and several other fungi.

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From The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways (2021) · cites this paper as [34]

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
Heitman, J., Movva, N. R., & Hall, M. N. (1991) · Science · doi:10.1126/science.1715094 · Cited by 2,010 · see citing works
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Pel, H. J., de Winde, J. H., Archer, D. B., Dyer, P. S., Hofmann, G., Schaap, P. J., Turner, G., de Vries, R. P., Albang, R., Albermann, K., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1282 · Cited by 1,174 · see citing works
Cell Wall Integrity Signaling in Saccharomyces cerevisiae
Levin, D. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.262-291.2005 · Cited by 1,136 · see citing works
Novel sensing mechanisms and targets for the cAMP–protein kinase A pathway in the yeast Saccharomyces cerevisiae
Thevelein, J. M., & WINDE, J. H. D. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01538.x · Cited by 682 · see citing works
Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiae
Chen, R. E., & Thorner, J. W. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.05.003 · Cited by 618 · see citing works
Calcineurin is required for virulence of Cryptococcus neoformans
Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2576 · Cited by 516 · see citing works
The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.Preprint
Kamada, Y., Jung, U. S., Piotrowski, J., & Levin, D. E. (1995) · Genes & Development · doi:10.1101/gad.9.13.1559 · Cited by 488 · see citing works
Identification of Yeast Rho1p GTPase as a Regulatory Subunit of 1,3-β-Glucan Synthase
Qadota, H., Python, C. P., Inoue, S., Arisawa, M., Anraku, Y., Zheng, Y., Watanabe, T., Levin, D. E., & Ohya, Y. (1996) · Science · doi:10.1126/science.272.5259.279 · Cited by 445 · see citing works
Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins
Walker, L. A., Munro, C. A., de Bruijn, I., Lenardon, M. D., McKinnon, A., & Gow, N. A. R. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000040 · Cited by 445 · see citing works
A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle
Levin, D. E., Fields, F. O., Kunisawa, R., Bishop, J. M., & Thorner, J. W. (1990) · Cell · doi:10.1016/0092-8674(90)90360-q · Cited by 413 · see citing works
The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase.
Douglas, C. M., Foor, F., Marrinan, J. A., Morin, N., Nielsen, J. B., Dahl, A. M., Mazur, P., Baginsky, W., Li, W., & el-Sherbeini, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12907 · Cited by 401 · see citing works
A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae
Verna, J., Lodder, A., Lee, K., Vagts, A. J., & Ballester, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13804 · Cited by 366 · see citing works
Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect.
Levin, D. E., & Bartlett-Heubusch, E. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.5.1221 · Cited by 363 · see citing works
The plasma membrane of Saccharomyces cerevisiae: structure, function, and biogenesis
van der Rest, M. E., Kamminga, A. H., Nakano, A., Anraku, Y., Poolman, B., & Konings, W. N. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.304-322.1995 · Cited by 359 · see citing works
Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence
Sanglard, D., Ischer, F., Marchetti, O., Entenza, J., & Bille, J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03495.x · Cited by 350 · see citing works
Regulatory Mechanisms for Modulation of Signaling through the Cell Integrity Slt2-mediated Pathway in Saccharomyces cerevisiae
Martı́n, H., Rodrı́guez-Pachón, J. M., Ruiz, C., Nombela, C., & Molina, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1511 · Cited by 343 · see citing works
A downstream target of RHO1 small GTP‐binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.
Nonaka, H., Tanaka, K., Hirano, H., Fujiwara, T., Kohno, H., Umikawa, M., Mino, A., & Takai, Y. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00281.x · Cited by 341 · see citing works
Rho1p, a Yeast Protein at the Interface Between Cell Polarization and Morphogenesis
Drgonová, J., Drgon, T., Tanaka, K., KOLLÁR, R., Chen, G.-C., Ford, R. A., Chan, C. S. M., Takai, Y., & Cabib, E. (1996) · Science · doi:10.1126/science.272.5259.277 · Cited by 336 · see citing works
Yeast Osmoregulation
Hohmann, S., Krantz, M., & Nordlander, B. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)28002-4 · Cited by 316 · see citing works
MKK1 and MKK2 , Which Encode Saccharomyces cerevisiae Mitogen-Activated Protein Kinase-Kinase Homologs, Function in the Pathway Mediated by Protein Kinase C
Irie, K., Takase, M., Lee, K. S., Levin, D. E., Araki, H., Matsumoto, K., & Oshima, Y. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.3076-3083.1993 · Cited by 316 · see citing works
Dominant Mutations in a Gene Encoding a Putative Protein Kinase (BCKT) Bypass the Requirement for a Saccharomyces cerevisiae Protein Kinase C Homolog
Lee, K. S., & Levin, D. E. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.172-182.1992 · Cited by 315 · see citing works
The Hog1 Mitogen-Activated Protein Kinase Is Essential in the Oxidative Stress Response and Chlamydospore Formation inCandidaalbicans
Alonso-Monge, R., Navarro-García, F., Román, E., Negredo, A. I., Eisman, B., Nombela, C., & Pla, J. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.2.351-361.2003 · Cited by 308 · see citing works
Wsc1 and Mid2 Are Cell Surface Sensors for Cell Wall Integrity Signaling That Act through Rom2, a Guanine Nucleotide Exchange Factor for Rho1
Philip, B., & Levin, D. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.271-280.2001 · Cited by 304 · see citing works
The Yeast Phosphatidylinositol Kinase Homolog TOR2 Activates RHO1 and RHO2 via the Exchange Factor ROM2
Schmidt, A., Bickle, M., Beck, T. W., & Hall, M. N. (1997) · Cell · doi:10.1016/s0092-8674(00)81893-0 · Cited by 300 · see citing works
Signalling in the Yeasts: An Informational Cascade with Links to the Filamentous Fungi
Banuett, F. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.249-274.1998 · Cited by 297 · see citing works
IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein.
Tanaka, K., Nakafuku, M., Tamanoi, F., Kaziro, Y., Matsumoto, K., & Toh‐e, A. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.4303 · Cited by 292 · see citing works
Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase
Cyert, M. S., Kunisawa, R., Kaim, D., & Thorner, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7376 · Cited by 289 · see citing works
A Second Osmosensing Signal Transduction Pathway in Yeast
Davenport, K., Sohaskey, M. L., Kamada, Y., Levin, D. E., & Gustin, M. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.30157 · Cited by 280 · see citing works
Activation of Yeast Protein Kinase C by Rho1 GTPase
Kamada, Y., Qadota, H., Python, C. P., Anraku, Y., Ohya, Y., & Levin, D. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9193 · Cited by 280 · see citing works
Cell wall perturbation in yeast results in dual phosphorylation of the Slt2/Mpk1 MAP kinase and in an Slt2-mediated increase in FKS2–lacZ expression, glucanase resistance and thermotolerance
de Nobel, H., Ruiz, C., Martı́n, H., Morris, W. L., Brul, S., Molina, M., & Klis, F. M. (2000) · Microbiology · doi:10.1099/00221287-146-9-2121 · Cited by 269 · see citing works
Saccharomyces cerevisiae Mid2p Is a Potential Cell Wall Stress Sensor and Upstream Activator of the PKC1-MPK1 Cell Integrity Pathway
Ketela, T., Green, R., & Bussey, H. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.11.3330-3340.1999 · Cited by 263 · see citing works
TOR2 is required for organization of the actin cytoskeleton in yeast
Schmidt, A., Kunz, J., & Hall, M. N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13780 · Cited by 263 · see citing works
Genome-wide Analysis of the Response to Cell Wall Mutations in the Yeast Saccharomyces cerevisiae
Lagorce, A., Hauser, N. C., Labourdette, D., Rodriguez, C., Martin-Yken, H., Arroyo, J., Hoheisel, J. D., & François, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211604200 · Cited by 254 · see citing works
SBF Cell Cycle Regulator as a Target of the Yeast PKC-MAP Kinase Pathway
Madden, K. T., Sheu, Y.-J., Baetz, K., Andrews, B., & Snyder, M. P. (1997) · Science · doi:10.1126/science.275.5307.1781 · Cited by 250 · see citing works
Regulation of the yeast Rlm1 transcription factor by the Mpk1 cell wall integrity MAP kinase
Jung, U. S., Sobering, A. K., Romeo, M. J., & Levin, D. E. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03198.x · Cited by 237 · see citing works
Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.
Cyert, M., & Thorner, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3460 · Cited by 236 · see citing works
The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function
Kraus, P. R., Fox, D. S., Cox, G. M., & Heitman, J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03508.x · Cited by 217 · see citing works
The Fission Yeast pmk1+ Gene Encodes a Novel Mitogen-Activated Protein Kinase Homolog Which Regulates Cell Integrity and Functions Coordinately with the Protein Kinase C Pathway
Toda, T., Dhut, S., Superti‐Furga, G., Gotoh, Y., Nishida, E., Sugiura, R., & Kuno, T. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6752 · Cited by 210 · see citing works
Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae.
Ozaki, K., Tanaka, K., Imamura, H., Hihara, T., Kameyama, T., Nonaka, H., Hirano, H., Matsuura, Y., & Takai, Y. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00573.x · Cited by 209 · see citing works
Investigating the caffeine effects in the yeast Saccharomyces cerevisiae brings new insights into the connection between TOR, PKC and Ras/cAMP signalling pathways
Kuranda, K., Berre, V. L., Sokol, S., Palamarczyk, G., & François, J. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05300.x · Cited by 206 · see citing works
The sequential activation of the yeast HOG and SLT2 pathways is required for cell survival to cell wall stress
Bermejo, C., Rodríguez, E., García, R., Rodríguez-Peña, J. M., Rodríguez de la Concepción, M. L., Rivas, C., Arias, P., Nombela, C., Posas, F., & Arroyo, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0742 · Cited by 204 · see citing works
Yeast RLM1 Encodes a Serum Response Factor-Like Protein That May Function Downstream of the Mpk1 (Slt2) Mitogen-Activated Protein Kinase Pathway
Watanabe, Y., Irie, K., & Matsumoto, K. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5740 · Cited by 198 · see citing works
Activity of 1,3-β-D-Glucan Synthase Requires the GTP-binding Protein Rho1
Mazur, P., & Baginsky, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14604 · Cited by 196 · see citing works
The Saccharomyces cerevisiae MADS-Box Transcription Factor Rlm1 Is a Target for the Mpk1 Mitogen-Activated Protein Kinase Pathway
Dodou, E., & Treisman, R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.1848 · Cited by 196 · see citing works
A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants
Torres, L., Martı́n, H., García-Sáez, M. I., Arroyo, J., Molina, M., Sánchez, M., & Nombela, C. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb01993.x · Cited by 191 · see citing works
High Resistance to Oxidative Stress in the Fungal Pathogen Candida glabrata Is Mediated by a Single Catalase, Cta1p, and Is Controlled by the Transcription Factors Yap1p, Skn7p, Msn2p, and Msn4p
Cuéllar-Cruz, M., Briones-Martin-del-Campo, M., Cañas-Villamar, I., Montalvo-Arredondo, J., Riego-Ruiz, L., Castaño, I., & De Las Peñas, A. (2008) · Eukaryotic Cell · doi:10.1128/ec.00011-08 · Cited by 190 · see citing works
Calcineurin, the Ca2+/Calmodulin-Dependent Protein Phosphatase, Is Essential in Yeast Mutants with Cell Integrity Defects and in Mutants That Lack a Functional Vacuolar H+-Atpase
Garrett-Engele, P. W., Moilanen, B., & Cyert, M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4103 · Cited by 187 · see citing works
Functional Characterization of the MKC1 Gene of Candida albicans , Which Encodes a Mitogen-Activated Protein Kinase Homolog Related to Cell Integrity
Navarro-García, F., Sánchez, M., Plá, J., & Nombela, C. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2197 · Cited by 182 · see citing works
TheSaccharomyces cerevisiae genes (CMP1 andCMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B
Liu, Y., Ishii, S., Tokai, M., Tsutsumi, H., Ohki, O., Akada, R., Tanaka, K., Tsuchiya, E., Fukui, S., & Miyakawa, T. (1991) · Molecular and General Genetics MGG · doi:10.1007/bf00260706 · Cited by 177 · see citing works
Master and Commander in Fungal Pathogens: the Two-Component System and the HOG Signaling Pathway
Bahn, Y. (2008) · Eukaryotic Cell · doi:10.1128/ec.00323-08 · Cited by 175 · see citing works
TOR2 Is Part of Two Related Signaling Pathways Coordinating Cell Growth in Saccharomyces cerevisiae
Helliwell, S. B., Howald, I., Barbet, N., & Hall, M. N. (1998) · Genetics · doi:10.1093/genetics/148.1.99 · Cited by 171 · see citing works
A calcineurin-like gene ppb1 + in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning
Yoshida, T., Toda, T., & Yanagida, M. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.7.1725 · Cited by 169 · see citing works
The High Osmotic Response and Cell Wall Integrity Pathways Cooperate to Regulate Transcriptional Responses to Zymolyase-induced Cell Wall Stress in Saccharomyces cerevisiae
García, R., Rodríguez-Peña, J. M., Bermejo, C., Nombela, C., & Arroyo, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808693200 · Cited by 165 · see citing works
Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR
Cruz, M. C., Goldstein, A. L., Blankenship, J., Del Poeta, M., Perfect, J. R., McCusker, J. H., Bennani, Y. L., Cardenas, M. E., & Heitman, J. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.11.3162-3170.2001 · Cited by 159 · see citing works
Pkc1 and the Upstream Elements of the Cell Integrity Pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, Are Required for Cellular Responses to Oxidative Stress*
Vilella, F., Herrero, E., Torres, J., & de la Torre-Ruiz, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411062200 · Cited by 155 · see citing works
The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response
Valiante, V., Heinekamp, T., Jain, R., Härtl, A., & Brakhage, A. A. (2007) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2007.09.006 · Cited by 153 · see citing works
Signalling pathways in the pathogenesis of Cryptococcus
Kozubowski, L., Lee, S. C., & Heitman, J. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01273.x · Cited by 150 · see citing works
Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans
Gerik, K. J., Donlin, M. J., Soto, C. E., Banks, A. M., Banks, I. R., Maligie, M. A., Selitrennikoff, C. P., & Lodge, J. K. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04843.x · Cited by 146 · see citing works
Regulation of the Cell Integrity Pathway by Rapamycin-sensitive TOR Function in Budding Yeast
Torres‐Rosell, J., Como, C. J. D., Herrero, E., & de la Torre-Ruiz, M. Á. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205408200 · Cited by 144 · see citing works
Good fungi gone bad: The corruption of calcineurin
Fox, D. S., & Heitman, J. (2002) · BioEssays · doi:10.1002/bies.10157 · Cited by 137 · see citing works
The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans
Navarro-García, F., Eisman, B., Fiuza, S. M., Nombela, C., & Pla, J. (2005) · Microbiology · doi:10.1099/mic.0.28038-0 · Cited by 134 · see citing works
Signaling Alkaline pH Stress in the Yeast Saccharomyces cerevisiae through the Wsc1 Cell Surface Sensor and the Slt2 MAPK Pathway
Serrano, R., Martı́n, H., Casamayor, A., & Ariño, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604497200 · Cited by 129 · see citing works
Fission yeast Tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature
Available, N. A. N., Available, N. A. N., Available, N. A. N., Available, N. A. N., Available, N. A. N., Available, N. A. N., & Available, N. A. N. (2001) · Current Genetics · doi:10.1007/s002940100198 · Cited by 128 · see citing works
Regulation of the Saccharomyces cerevisiae Slt2 Kinase Pathway by the Stress-inducible Sdp1 Dual Specificity Phosphatase
Hahn, J., & Thiele, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202557200 · Cited by 126 · see citing works
The Saccharomyces cerevisiae sln1p-ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion
Singh, K. K. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00432-9 · Cited by 119 · see citing works
Spm1, a stress‐activated MAP kinase that regulates morphogenesis in S.pombe
Zaitsevskaya-Carter, T., & Cooper, J. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.6.1318 · Cited by 117 · see citing works
The calmodulin‐dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
Rasmussen, C. D., Garen, C. R., Brining, S. K., Kincaid, R. L., Means, R. L., & Means, A. R. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06544.x · Cited by 115 · see citing works
Stress-induced Response, Localization, and Regulation of the Pmk1 Cell Integrity Pathway in Schizosaccharomyces pombe
Madrid, M., Soto, T., Khong, H.-K., Franco, A., Vicente‐Soler, J., Pérez, P., Gacto, M., & Cansado, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506467200 · Cited by 115 · see citing works
PKC1 Is Essential for Protection against both Oxidative and Nitrosative Stresses, Cell Integrity, and Normal Manifestation of Virulence Factors in the Pathogenic Fungus Cryptococcus neoformans
Gerik, K. J., Bhimireddy, S. R., Ryerse, J. S., Specht, C. A., & Lodge, J. K. (2008) · Eukaryotic Cell · doi:10.1128/ec.00146-08 · Cited by 107 · see citing works
The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans
Arana, D. M., Nombela, C., Alonso‐Monge, R., & Plá, J. (2005) · Microbiology · doi:10.1099/mic.0.27723-0 · Cited by 104 · see citing works
cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae
Kuno, T., Tanaka, H., Mukai, H., Chang, C., Hiraga, K., Miyakawa, T., & Tanaka, C. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81188-x · Cited by 94 · see citing works
Stress-specific Activation Mechanisms for the “Cell Integrity” MAPK Pathway
Harrison, J. C., Zyla, T. R., Bardes, E. S. G., & Lew, D. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306110200 · Cited by 92 · see citing works
The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth
Eng, W.-K., Faucette, L. F., McLaughlin, M. M., Cafferkey, R., Koltin, Y., Morris, R. A., Young, P. R., Johnson, R. K., & Livi, G. P. (1994) · Gene · doi:10.1016/0378-1119(94)90633-5 · Cited by 86 · see citing works
IRA2 , a Second Gene of Saccharomyces cerevisiae That Encodes a Protein with a Domain Homologous to Mammalian ras GTPase-Activating Protein
Tanaka, K., Nakafuku, M., Tamanoi, F., Kaziro, Y., Matsumoto, K., & Toh‐e, A. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.4303-4313.1990 · Cited by 85 · see citing works
Regulatory Subunit (CNB1 Gene Product) of Yeast Ca2+/Calmodulin-Dependent Phosphoprotein Phosphatases Is Required for Adaptation to Pheromone
Cyert, M., & Thorner, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3460-3469.1992 · Cited by 82 · see citing works
TheCandida albicans PKC1 gene encodes a protein kinase C homolog necessary for cellular integrity but not dimorphism
Paravicini, G., Mendoza-Losana, A., Antonsson, B. E., Cooper, M., Losberger, C., & Payton, M. A. (1996) · Yeast · doi:10.1002/(sici)1097-0061(19960630)12:8 · Cited by 78 · see citing works
Susceptibility of Cryptococcus neoformans to Photodynamic Inactivation Is Associated with Cell Wall Integrity
Fuchs, B. B., Tegos, G. P., Hamblin, M. R., & Mylonakis, E. E. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00121-07 · Cited by 75 · see citing works
Self-citation
Deletion of the Aspergillus fumigatus Gene Encoding the Ras-Related Protein RhbA Reduces Virulence in a Model of Invasive Pulmonary Aspergillosis
Panepinto, J. C., Oliver, B. G., Fortwendel, J. R., Smith, D. L. H., Askew, D. S., & Rhodes, J. C. (2003) · Infection and Immunity · doi:10.1128/iai.71.5.2819-2826.2003 · Cited by 72 · see citing works
Ssk2 Mitogen-Activated Protein Kinase Kinase Kinase Governs Divergent Patterns of the Stress-Activated Hog1 Signaling Pathway in Cryptococcus neoformans
Bahn, Y., Geunes-Boyer, S., & Heitman, J. (2007) · Eukaryotic Cell · doi:10.1128/ec.00349-07 · Cited by 71 · see citing works
A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans
Tsao, C.-C., Chen, Y.-T., & Lan, C. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.11.008 · Cited by 56 · see citing works
The Rgd1p Rho GTPase-Activating Protein and the Mid2p Cell Wall Sensor Are Required at Low pH for Protein Kinase C Pathway Activation and Cell Survival in Saccharomyces cerevisiae
Claret, S. B., Gatti, X., Doignon, F., Thoraval, D. H., & Crouzet, M. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.8.1375-1386.2005 · Cited by 54 · see citing works
The calmodulin‐dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
Rasmussen, C. D., Garen, C. R., Brining, S. K., Kincaid, R. L., Means, R. L., & Means, A. R. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06703.x · Cited by 50 · see citing works
RGD1, encoding a RhoGAP involved in low-pH survival, is an Msn2p/Msn4p regulated gene in Saccharomyces cerevisiae
Gatti, X., de Bettignies, G., Claret, S. B., Doignon, F., Crouzet, M., & Thoraval, D. H. (2005) · Gene · doi:10.1016/j.gene.2005.03.034 · Cited by 22 · see citing works
The Synthetic Genetic Network around PKC1 Identifies Novel Modulators and Components of Protein Kinase C Signaling in Saccharomyces cerevisiae
Krause, S. A., Xu, H., & Gray, J. V. (2008) · Eukaryotic Cell · doi:10.1128/ec.00222-08 · Cited by 22 · see citing works
Overactivation of the Protein Kinase C-Signaling Pathway Suppresses the Defects of Cells Lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae
de Bettignies, G., Thoraval, D. H., Morel, C., Peypouquet, M., & Crouzet, M. (2001) · Genetics · doi:10.1093/genetics/159.4.1435 · Cited by 21 · see citing works
Insight into the Role of HOG Pathway Components Ssk2p, Pbs2p, and Hog1p in the Opportunistic Yeast Candida lusitaniae
Boisnard, S., Ruprich‐Robert, G., Florent, M., Silva, B. D., Chapeland‐Leclerc, F., & Papon, N. (2008) · Eukaryotic Cell · doi:10.1128/ec.00262-08 · Cited by 11 · see citing works
De las penas
Moncayo, L. A. (1977) · Cited by 9 · see citing works

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Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae
Conrad, M., Schothorst, J., Kankipati, H., Zeebroeck, G. V., Rubio‐Texeira, M., & Thevelein, J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12065 · Cited by 616 · see citing works
Regulatory circuitry governing fungal development, drug resistance, and disease.
Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576 · see citing works
PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90
LaFayette, S. L., Collins, C., Zaas, A. K., Schell, W. A., Betancourt-Quiroz, M., Gunatilaka, A. A. L., Perfect, J. R., & Cowen, L. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001069 · Cited by 329 · see citing works
Molecular mechanisms of Saccharomyces cerevisiae stress adaptation and programmed cell death in response to acetic acid
Giannattasio, S., Guaragnella, N., Ždralević, M., & Marra, E. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00033 · Cited by 197 · see citing works
The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence
Valiante, V., Macheleidt, J., Föge, M., & Brakhage, A. A. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00325 · Cited by 184 · see citing works
The high‐osmolarity glycerol (HOG) and cell wall integrity (CWI) signalling pathways interplay: a yeast dialogue between MAPK routes
Rodríguez-Peña, J. M., García, R., Nombela, C., & Arroyo, J. (2010) · Yeast · doi:10.1002/yea.1792 · Cited by 182 · see citing works
The bacterial lipopeptide iturins induce V erticillium dahliae cell death by affecting fungal signalling pathways and mediate plant defence responses involved in pathogen‐associated molecular pattern‐triggered immunity
Han, Q., Wu, F., Wang, X., Qi, H., Shi, L., Ren, A., Liu, Q., Zhao, M., & Tang, C. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12538 · Cited by 174 · see citing works
Interface of Candida albicans Biofilm Matrix-Associated Drug Resistance and Cell Wall Integrity Regulation
Nett, J. E., Sanchez, H., Cain, M. T., Ross, K. M., & Andes, D. R. (2011) · Eukaryotic Cell · doi:10.1128/ec.05126-11 · Cited by 168 · see citing works
Calcineurin-Crz1 Signaling in Lower Eukaryotes
Thewes, S. (2014) · Eukaryotic Cell · doi:10.1128/ec.00038-14 · Cited by 152 · see citing works
The cell wall and the response and tolerance to stresses of biotechnological relevance in yeasts
Ribeiro, R. A., Bourbon-Melo, N., & Sá‐Correia, I. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.953479 · Cited by 155 · see citing works
Osmolytes and their Role in Abiotic Stress Tolerance in Plants
Jogawat, A. (2019) · doi:10.1002/9781119463665.ch5 · Cited by 146 · see citing works
Cell wall integrity signalling in human pathogenic fungi: CWI signalling in pathogenic fungi
Dichtl, K., Samantaray, S., & Wagener, J. (2016) · Cellular Microbiology · doi:10.1111/cmi.12612 · Cited by 144 · see citing works
The Future of Antifungal Drug Therapy: Novel Compounds and Targets
Mota Fernandes, C., Dasilva, D., Haranahalli, K., McCarthy, J. B., Mallamo, J., Ojima, I., & Del Poeta, M. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01719-20 · Cited by 124 · see citing works
Together we are strong—cell wall integrity sensors in yeasts
Rodicio, R., & Heinisch, J. J. (2010) · Yeast · doi:10.1002/yea.1785 · Cited by 114 · see citing works
Responses of Aspergillus flavus to Oxidative Stress Are Related to Fungal Development Regulator, Antioxidant Enzyme, and Secondary Metabolite Biosynthetic Gene Expression
Fountain, J. C., Bajaj, P., Nayak, S. N., Yang, L., Pandey, M. K., Kumar, V., Jayale, A. S., Chitikineni, A., Lee, R. D., Kemerait, R. C., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02048 · Cited by 108 · see citing works
The MAP kinase Bbslt2 controls growth, conidiation, cell wall integrity, and virulence in the insect pathogenic fungus Beauveria bassiana
Luo, X., Keyhani, N. O., Yu, X., He, Z., Luo, Z., Pei, Y., & Zhang, Y. (2012) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2012.05.002 · Cited by 106 · see citing works
pH Signaling in Human Fungal Pathogens: a New Target for Antifungal Strategies
Cornet, M., & Gaillardin, C. M. (2014) · Eukaryotic Cell · doi:10.1128/ec.00313-13 · Cited by 99 · see citing works
Protein kinase C in fungi—more than just cell wall integrity
Heinisch, J. J., & Rodicio, R. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux051 · Cited by 96 · see citing works
Aspergillus fumigatus MADS-Box Transcription Factor rlmA Is Required for Regulation of the Cell Wall Integrity and Virulence
Rocha, M. C., Fabri, J. H. T. M., de Godoy, K. F., de Castro, P. A., Hori, J. I., da Cunha, A. F., Arentshorst, M., Ram, A. F. J., van den Hondel, C. A. M. J. J., Goldman, G. H., et al. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.031112 · Cited by 94 · see citing works
Coordination of the Cell Wall Integrity and High-Osmolarity Glycerol Pathways in Response to Ethanol Stress in Saccharomyces cerevisiae
Udom, N., Chansongkrow, P., Charoensawan, V., & Auesukaree, C. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.00551-19 · Cited by 90 · see citing works
Chitin and chitosan remodeling defines vegetative development and Trichoderma biocontrol
Kappel, L., Münsterkötter, M., Sipos, G., Rodríguez, C. E., & Gruber, S. G. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008320 · Cited by 88 · see citing works
Histone Deacetylases and Their Inhibition in Candida Species
Garnaud, C., Champleboux, M., Maubon, D., Cornet, M., & Govin, J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01238 · Cited by 85 · see citing works
Phosphodiesterase MoPdeH targets MoM ck1 of the conserved mitogen‐activated protein ( MAP ) kinase signalling pathway to regulate cell wall integrity in rice blast fungus M agnaporthe oryzae
Yin, Z., Tang, W., Wang, J., Liu, X., Yang, L., Gao, C., Zhang, J., Zhang, H., Zheng, X., Wang, P., et al. (2015) · Molecular Plant Pathology · doi:10.1111/mpp.12317 · Cited by 80 · see citing works
The osmosensing signal transduction pathway from Botrytis cinerea regulates cell wall integrity and MAP kinase pathways control melanin biosynthesis with influence of light
Liu, W., Soulié, M., Perrino, C., & Fillinger, S. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2010.12.004 · Cited by 79 · see citing works
Signaling and Communication in Plants
Mugnai, S. (2011) · Frontiers in artificial intelligence and applications · doi:10.3233/978-1-60750-972-1-205 · Cited by 80 · see citing works
Distribution and impact of yeast thermal tolerance permissive for mammalian infection
Robert, V., Cardinali, G., & Casadevall, A. (2015) · BMC Biology · doi:10.1186/s12915-015-0127-3 · Cited by 79 · see citing works
Lack of tRNA Modification Isopentenyl-A37 Alters mRNA Decoding and Causes Metabolic Deficiencies in Fission Yeast
Lamichhane, T. N., Blewett, N. H., Crawford, A. K., Cherkasova, V. A., Iben, J., Begley, T. J., Farabaugh, P. J., & Maraia, R. J. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00278-13 · Cited by 78 · see citing works
Global Survey of Canonical Aspergillus flavus G Protein-Coupled Receptors
Affeldt, K. J., Carrig, J., Amare, M., & Keller, N. P. (2014) · mBio · doi:10.1128/mbio.01501-14 · Cited by 77 · see citing works
Insights into regulatory roles of MAPK-cascaded pathways in multiple stress responses and life cycles of insect and nematode mycopathogens
Tong, S., & Feng, M. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9516-1 · Cited by 73 · see citing works
Fungal attacks on mammalian hosts: pathogen elimination requires sensing and tasting
Bourgeois, C., Majer, O., Frohner, I. E., Tierney, L., & Kuchler, K. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.05.004 · Cited by 71 · see citing works
Three Mitogen-Activated Protein Kinases Required for Cell Wall Integrity Contribute Greatly to Biocontrol Potential of a Fungal Entomopathogen
Chen, Y., Zhu, J. K., Ying, S., & Feng, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087948 · Cited by 70 · see citing works
Microbial stress priming: a meta‐analysis
Linares, D. R. A., Lehmann, A., & Rillig, M. C. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13223 · Cited by 68 · see citing works
Putative Calcium Channels CchA and MidA Play the Important Roles in Conidiation, Hyphal Polarity and Cell Wall Components in Aspergillus nidulans
Wang, S., Cao, J., Liu, X., Hu, H., Shi, J. R., Zhang, S., Keller, N. P., & Lü, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046564 · Cited by 64 · see citing works
Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus
Altwasser, R., Baldin, C., Weber, J., Guthke, R., Kniemeyer, O., Brakhage, A. A., Linde, J., & Valiante, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136932 · Cited by 63 · see citing works
Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling
Villa‐Garcia, M., Choi, M. S., Hinz, F. I., Gaspar, M. L., Jesch, S. A., & Henry, S. A. (2010) · Molecular Genetics and Genomics · doi:10.1007/s00438-010-0592-x · Cited by 63 · see citing works
PRO40 Is a Scaffold Protein of the Cell Wall Integrity Pathway, Linking the MAP Kinase Module to the Upstream Activator Protein Kinase C
Teichert, I., Steffens, E. K., Schnaß, N., Fränzel, B., Krisp, C., Wolters, D. A., & Kück, U. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004582 · Cited by 63 · see citing works
Adaptive differentiation coincides with local bioclimatic conditions along an elevational cline in populations of a lichen-forming fungus
Grande, F. D., Sharma, R., Meiser, A., Rolshausen, G., Büdel, B., Mishra, B., Thines, M., Otte, J., Pfenninger, M., & Schmitt, I. (2017) · BMC Evolutionary Biology · doi:10.1186/s12862-017-0929-8 · Cited by 61 · see citing works
The Interactions Between Candida albicans and Mucosal Immunity
Zhou, Y., Cheng, L., Lei, Y. L., Ren, B., & Zhou, X. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.652725 · Cited by 65 · see citing works
Type 2C Protein Phosphatases in Fungi
Ariño, J., Casamayor, A., & González, A. (2010) · Eukaryotic Cell · doi:10.1128/ec.00249-10 · Cited by 62 · see citing works
Effect of cell wall integrity stress and RlmA transcription factor on asexual development and autolysis in Aspergillus nidulans
Kovács, Z., Szarka, M., Kovács, S., Boczonádi, I., Emri, T., Abe, K., Pócsi, I., & Pusztahelyi, T. (2013) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2013.02.004 · Cited by 61 · see citing works
The two-component response regulator Ssk1 and the mitogen-activated protein kinase Hog1 control antifungal drug resistance and cell wall architecture of Candida auris
Shivarathri, R., Jenull, S., Stoiber, A., Chauhan, M., Mazumdar, R., Singh, A., Nogueira, F., Kuchler, K., Chowdhary, A., & Chauhan, N. (2020) · mSphere · doi:10.1128/msphere.00973-20 · Cited by 59 · see citing works
The MAPK kinase BcMkk1 suppresses oxalic acid biosynthesis via impeding phosphorylation of BcRim15 by BcSch9 in Botrytis cinerea
Yin, Y., Wu, S., Chui, C., Ma, T., Jiang, H., Hahn, M., & Ma, Z. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007285 · Cited by 58 · see citing works
Use of atomic force microscopy (AFM) to explore cell wall properties and response to stress in the yeast Saccharomyces cerevisiae
François, J., Formosa‐Dague, C., Schiavone, M., Pillet, F., Martin‐Yken, H., & Dague, É. (2013) · Current Genetics · doi:10.1007/s00294-013-0411-0 · Cited by 58 · see citing works
Genetic Mapping of MAPK-Mediated Complex Traits Across S. cerevisiae
Treusch, S., Albert, F. W., Bloom, J. S., Kotenko, I., & Kruglyak, L. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004913 · Cited by 58 · see citing works
Survival Strategies of Yeast and Filamentous Fungi against the Antifungal Protein AFP
Ouedraogo, J., Hagen, S., Spielvogel, A., Engelhardt, S., & Meyer, V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.203588 · Cited by 58 · see citing works
Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans
Shahina, Z., El-Ganiny, A. M., Minion, J., Whiteway, M. S., Sultana, T., & Dahms, T. E. S. (2018) · Fungal Biology and Biotechnology · doi:10.1186/s40694-018-0046-5 · Cited by 57 · see citing works
Saprotrophic competitiveness and biocontrol fitness of a genetically modified strain of the plant-growth-promoting fungus Trichoderma hamatum GD12
Ryder, L. S., Harris, B. D., Soanes, D. M., Kershaw, M. J., Talbot, N. J., & Thornton, C. R. (2011) · Microbiology · doi:10.1099/mic.0.051854-0 · Cited by 55 · see citing works
Chitin Biosynthesis in Aspergillus Species
Brauer, V. S., Pessoni, A. M., Freitas, M. S., Neto, M. P. C., Ries, L. N. A., & Almeida, F. B. D. R. (2023) · Journal of Fungi · doi:10.3390/jof9010089 · Cited by 55 · see citing works
Characterization of A spergillus nidulans α‐glucan synthesis: roles for two synthases and two amylases
He, X., Li, S., & Kaminskyj, S. G. W. (2013) · Molecular Microbiology · doi:10.1111/mmi.12480 · Cited by 55 · see citing works
A Conserved Role of IQGAP1 in Regulating TOR Complex 1
Tekletsadik, Y. K., Sonn, R., & Osman, M. A. (2012) · Journal of Cell Science · doi:10.1242/jcs.098947 · Cited by 53 · see citing works
Participation of CWI, HOG and Calcineurin pathways in the tolerance of Saccharomyces cerevisiae to low pH by inorganic acid
de Lucena, R. M., Elsztein, C., Simões, D. A., & de Morais, M. A. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05362.x · Cited by 50 · see citing works
A Multi-Host Approach for the Systematic Analysis of Virulence Factors inCryptococcus neoformans
Desalermos, A. P., Tan, X., Rajamuthiah, R., Arvanitis, M., Wang, Y., Li, D., Kourkoumpetis, T. K., Fuchs, B. B., & Mylonakis, E. E. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu441 · Cited by 49 · see citing works
Self-citation
Post-Translational Modifications Drive Success and Failure of Fungal–Host Interactions
Retanal, C., Ball, B., & Geddes‐McAlister, J. (2021) · Journal of Fungi · doi:10.3390/jof7020124 · Cited by 49 · see citing works
Impact of the antifungal protein PgAFP from Penicillium chrysogenum on the protein profile in Aspergillus flavus
Delgado, J., Owens, R. A., Doyle, S., Asensio, M. A., & Núñez, F. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6731-x · Cited by 47 · see citing works
The Heat Shock Transcription Factor HsfA Is Essential for Thermotolerance and Regulates Cell Wall Integrity in Aspergillus fumigatus
Fabri, J. H. T. M., Rocha, M. C., Fernandes, C. M., Persinoti, G. F., Ries, L. N. A., da Cunha, A. F., Goldman, G. H., Poeta, M. D., & Malavazi, I. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.656548 · Cited by 48 · see citing works
Growth study under combined effects of temperature, pH and salinity and transcriptome analysis revealed adaptations of Aspergillus terreus NTOU4989 to the extreme conditions at Kueishan Island Hydrothermal Vent Field, Taiwan
Pang, K., Chiang, M., Guo, S., Shih, C.-Y., Dahms, H. U., Hwang, J., & Cha, H.-J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233621 · Cited by 46 · see citing works
Transcriptomic and molecular genetic analysis of the cell wall salvage response ofAspergillus nigerto the absence of galactofuranose synthesis
Park, J., Hulsman, M., Arentshorst, M., Breeman, M., Alazi, E., Lagendijk, E. L., Rocha, M. C., Malavazi, I., Nitsche, B. M., van den Hondel, C. A. M. J. J., et al. (2016) · Cellular Microbiology · doi:10.1111/cmi.12624 · Cited by 45 · see citing works
Involvement of the Cell Wall–Integrity Pathway in Signal Recognition, Cell-Wall Biosynthesis, and Virulence in Magnaporthe oryzae
Lu, K., Chen, R., Yang, Y., Xu, H., Jiang, J., & Li, L. (2023) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-11-22-0231-cr · Cited by 42 · see citing works
The Cell Wall Protein Ecm33 of Candida albicans is Involved in Chronological Life Span, Morphogenesis, Cell Wall Regeneration, Stress Tolerance, and Host–Cell Interaction
Gil-Bona, A., Reales‐Calderón, J. A., Parra‐Giraldo, C. M., Martínez‐López, R., Monteoliva, L., & Gil, C. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00064 · Cited by 40 · see citing works
Identification and Characterization of a Novel Issatchenkia orientalis GPI-Anchored Protein, IoGas1, Required for Resistance to Low pH and Salt Stress
Matsushika, A., Negi, K., Suzuki, T., Goshima, T., & Hoshino, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161888 · Cited by 42 · see citing works
The MAPKKK CgMck1 Is Required for Cell Wall Integrity, Appressorium Development, and Pathogenicity in Colletotrichum gloeosporioides
Fang, Y.-L., Xia, L., Wang, P., Zhu, L., Ye, J., & Huang, L. (2018) · Genes · doi:10.3390/genes9110543 · Cited by 41 · see citing works
Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs
Mount, H. O., Revie, N. M., Todd, R. T., Anstett, K., Collins, C., Costanzo, M., Boone, C., Robbins, N., Selmecki, A., & Cowen, L. E. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007319 · Cited by 34 · see citing works
A Myb Transcription Factor of Phytophthora sojae, Regulated by MAP Kinase PsSAK1, Is Required for Zoospore Development
Zhang, M., Lu, J., Tao, K. X., Ye, W., Li, A., Liu, X., Kong, L., Dong, S., Zheng, X., & Wang, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040246 · Cited by 40 · see citing works
The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways
Vu, B. G., Stamnes, M. A., Li, Y., Rogers, P. D., & Moye-Rowley, W. S. (2021) · PLOS Genetics · doi:10.1371/journal.pgen.1009582 · Cited by 39 · see citing works
Updating Insights into the Regulatory Mechanisms of Calcineurin-Activated Transcription Factor Crz1 in Pathogenic Fungi
Yang, Y. Y., Xie, P., Li, Y., Bi, Y., & Prusky, D. (2022) · Journal of Fungi · doi:10.3390/jof8101082 · Cited by 39 · see citing works
Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in Aspergillus fumigatus
de Assis, L. J., Manfiolli, A., Mattos, E., Fabri, J. H. T. M., Malavazi, I., Jacobsen, I. D., Brock, M., Cramer, R. A., Thammahong, A., Hagiwara, D., et al. (2018) · mBio · doi:10.1128/mbio.01952-18 · Cited by 38 · see citing works
The Sclerotinia sclerotiorum Slt2 mitogen-activated protein kinase ortholog, SMK3, is required for infection initiation but not lesion expansion
Bashi, Z. D., Gyawali, S., Bekkaoui, D. R., Coutu, C., Lee, L., Poon, J., Rimmer, S. R., Khachatourians, G. G., & Hegedus, D. D. (2016) · Canadian Journal of Microbiology · doi:10.1139/cjm-2016-0091 · Cited by 38 · see citing works
FvBck1, a component of cell wall integrity MAP kinase pathway, is required for virulence and oxidative stress response in sugarcane Pokkah Boeng pathogen
Zhang, C., Wang, J., Tao, H., Dang, X., Wang, Y., Chen, M., Zhai, Z., Yu, W., Xu, L., Shim, W., et al. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01096 · Cited by 37 · see citing works
Regulatory roles of phosphorylation in model and pathogenic fungi
Bataineh, M. T. A., & Kadosh, D. (2015) · Medical Mycology · doi:10.1093/mmy/myv098 · Cited by 36 · see citing works
SCWISh network is essential for survival under mechanical pressure
Delarue, M., Poterewicz, G., Hoxha, O., Choi, J., Yoo, W., Kayser, J., Holt, L. J., & Hallatschek, O. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711204114 · Cited by 36 · see citing works
Fungal tolerance to Congo red, a cell wall integrity stress, as a promising indicator of ecological niche
Lima, D. M. C. G., Costa, T. P. C., Emri, T., Pócsi, I., Pupin, B., & Rangel, D. E. N. (2021) · Fungal Biology · doi:10.1016/j.funbio.2021.03.007 · Cited by 36 · see citing works
The mitogen‐activated protein kinase CgHog1 is required for iron homeostasis, adherence and virulence in Candida glabrata
Srivastava, V. K., Suneetha, K. J., & Kaur, R. (2015) · The FEBS Journal · doi:10.1111/febs.13264 · Cited by 33 · see citing works
The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death
Nuckolls, N. L., Mok, A. C., Lange, J. J., Yi, K., Kandola, T. S., Hunn, A. M., McCroskey, S., Snyder, J. L., Núñez, M. A. B., McClain, M. L., et al. (2020) · eLife · doi:10.7554/elife.55694 · Cited by 32 · see citing works
Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction
Tóth, R., Cabral, V., Thuer, E., Bohner, F., Németh, T., Papp, C., Nimrichter, L., Attila, M. G., Vágvölgyi, C., Gabaldón, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-19453-4 · Cited by 33 · see citing works
Molecular Insights into Pathogenesis and Infection with Aspergillus fumigatus
Ghazaei, C. (2017) · Malaysian Journal of Medical Sciences · doi:10.21315/mjms2017.24.1.2 · Cited by 30 · see citing works
Comparative transcriptome and gene co-expression network analysis reveal genes and signaling pathways adaptively responsive to varied adverse stresses in the insect fungal pathogen, Beauveria bassiana
He, Z., Zhao, X., Lu, Z., Wang, H., Liu, P., Zeng, F., & Zhang, Y. (2017) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2017.12.002 · Cited by 30 · see citing works
Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance
Childers, D. S., Avelar, G. M., Bain, J. M., Larcombe, D. E., Pradhan, A., Budge, S., Heaney, H., & Brown, A. J. P. (2019) · Current topics in microbiology and immunology · doi:10.1007/82_2019_182 · Cited by 30 · see citing works
Proof-of-principle for SERS imaging of Aspergillus nidulans hyphae using in vivo synthesis of gold nanoparticles
Prusinkiewicz, M. A., Farazkhorasani, F., Dynes, J. J., Wang, J., Gough, K. M., & Kaminskyj, S. G. W. (2012) · The Analyst · doi:10.1039/c2an35620a · Cited by 30 · see citing works
Osmoregulation in Saccharomyces cerevisiae via mechanisms other than the high-osmolarity glycerol pathway
Saxena, A., & Sitaraman, R. (2016) · Microbiology · doi:10.1099/mic.0.000360 · Cited by 29 · see citing works
Understanding the effect of postharvest tomato temperatures on two toxigenic Alternaria spp. strains: growth, mycotoxins and cell‐wall integrity‐related gene expression
Cabral, L. D. C., Rodríguez, A., Delgado, J., & Patriarca, A. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9950 · Cited by 29 · see citing works
A high-throughput RNA-Seq approach to elucidate the transcriptional response of Piriformospora indica to high salt stress
Nivedita, Rawoof, A., Ramchiary, N., & Abdin, M. Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-82136-0 · Cited by 28 · see citing works
The Coupling Between Cell Wall Integrity Mediated by MAPK Kinases and SsFkh1 Is Involved in Sclerotia Formation and Pathogenicity of Sclerotinia sclerotiorum
Cong, J., Xiao, K., Jiao, W., Zhang, C., Zhang, X., Liu, J., Zhang, Y., & Pan, H. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.816091 · Cited by 28 · see citing works
Global Proteomic Profiling of the Secretome of Candida albicans ecm33 Cell Wall Mutant Reveals the Involvement of Ecm33 in Sap2 Secretion
Gil-Bona, A., Monteoliva, L., & Gil, C. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00411 · Cited by 28 · see citing works
Quantitative analysis of yeast MAPK signaling networks and crosstalk using a microfluidic device
Lee, B., Jeong, S., Jin, S. H., Mishra, R., Peter, M., Lee, C., & Lee, S. S. (2020) · Lab on a Chip · doi:10.1039/d0lc00203h · Cited by 27 · see citing works
Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2Preprint
Leskoske, K. L., Roelants, F. M., Emmerstorfer‐Augustin, A., Augustin, C. M., Si, E. P., Hill, J. M., & Thorner, J. (2018) · Genes & Development · doi:10.1101/gad.318709.118 · Cited by 27 · see citing works
Regulation of Neurospora crassa cell wall remodeling via the cot-1 pathway is mediated by gul-1
Herold, I., & Yarden, O. (2016) · Current Genetics · doi:10.1007/s00294-016-0625-z · Cited by 26 · see citing works
Physiological responses of Saccharomyces cerevisiae to industrially relevant conditions: Slow growth, low pH, and high CO2 levels
Hakkaart, X., Liu, Y., Hulst, M. B., el Masoudi, A., Peuscher, E., Pronk, J. T., van Gulik, W. M., & Daran-Lapujade, P. A. S. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27210 · Cited by 25 · see citing works
HgrA is necessary and sufficient to drive hyphal growth in the dimorphic pathogen P enicillium marneffei
Bugeja, H. E., Hynes, M. J., & Andrianopoulos, A. (2013) · Molecular Microbiology · doi:10.1111/mmi.12239 · Cited by 25 · see citing works
Mtl1 O-mannosylation mediated by both Pmt1 and Pmt2 is important for cell survival under oxidative conditions and TOR blockade
Petkova, M. I., Pujol‐Carrion, N., & de la Torre-Ruiz, M. Á. (2012) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2012.08.005 · Cited by 25 · see citing works
A Cdc42 homolog in Colletotrichum gloeosporioides regulates morphological development and is required for ROS-mediated plant infection
Wang, X., Xu, X., Liang, Y., Wang, Y., & Tian, C. (2018) · Current Genetics · doi:10.1007/s00294-018-0833-9 · Cited by 25 · see citing works
Differential response to synthetic and natural antifungals by Alternaria tenuissima in wheat simulating media: Growth, mycotoxin production and expression of a gene related to cell wall integrity
Cabral, L. D. C., Delgado, J., Patriarca, A., & Rodríguez, A. (2018) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2018.12.005 · Cited by 25 · see citing works
The DUF1996 and WSC domain‐containing protein Wsc1I acts as a novel sensor of multiple stress cues in Beauveria bassiana
Tong, S., Wang, D., Gao, B., Ying, S., & Feng, M. (2019) · Cellular Microbiology · doi:10.1111/cmi.13100 · Cited by 25 · see citing works
Tracking nickel‐adaptive biomarkers in Pisolithus albus from New Caledonia using a transcriptomic approach
Majorel, C., Hannibal, L., Soupé-Gilbert, M.-E., Carriconde, F., Ducousso, M., Lebrun, M., & Jourand, P. (2012) · Molecular Ecology · doi:10.1111/j.1365-294x.2012.05527.x · Cited by 24 · see citing works
Evaluation of Saccharomyces cerevisiae GAS1 with respect to its involvement in tolerance to low pH and salt stress
Matsushika, A., Suzuki, T., Goshima, T., & Hoshino, T. (2017) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2017.03.004 · Cited by 24 · see citing works
The stuA gene controls development, adaptation, stress tolerance, and virulence of the dermatophyte Trichophyton rubrum
Lang, E. A. S., Bitencourt, T. A., Peres, N. T. A., Lopes, L. R., Silva, L. G., Cazzaniga, R. A., Rossi, A., & Martinez-Rossi, N. M. (2020) · Microbiological Research · doi:10.1016/j.micres.2020.126592 · Cited by 24 · see citing works
cpsA regulates mycotoxin production, morphogenesis and cell wall biosynthesis in the fungus Aspergillus nidulans
Feng, X., Ramamoorthy, V., Pandit, S. S., Prieto, A., Espeso, E. A., & Calvo, A. M. (2017) · Molecular Microbiology · doi:10.1111/mmi.13682 · Cited by 23 · see citing works
Application of recyclable CRISPR/Cas9 tools for targeted genome editing in the postharvest pathogenic fungi Penicillium digitatum and Penicillium expansum
Garrigues, S., Manzanares, P., & Marcos, J. F. (2022) · Current Genetics · doi:10.1007/s00294-022-01236-0 · Cited by 23 · see citing works
Actin - a biosensor that determines cell fate in yeasts
Smethurst, D. G. J., Dawes, I. W., & Gourlay, C. W. (2013) · FEMS Yeast Research · doi:10.1111/1567-1364.12119 · Cited by 23 · see citing works
Low temperature highlights the functional role of the cell wall integrity pathway in the regulation of growth in Saccharomyces cerevisiae
Córcoles-Sáez, I., Ballester‐Tomás, L., de la Torre-Ruiz, M. Á., Prieto, J. A., & Rández‐Gil, F. (2012) · Biochemical Journal · doi:10.1042/bj20120634 · Cited by 23 · see citing works
Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shock
Kuravi, V. K., Kurischko, C., Puri, M., & Luca, F. C. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-04-0371 · Cited by 23 · see citing works

The Fungal Cell Wall Integrity Pathway
Molina, M., & Martín, H. (2023) · MDPI eBooks · doi:10.3390/books978-3-0365-6972-7
Cell wall integrity signalling in human pathogenic fungi: CWI signalling in pathogenic fungi
Dichtl, K., Samantaray, S., & Wagener, J. (2016) · Cellular Microbiology · doi:10.1111/cmi.12612 · Cited by 144 · see citing works
Hilfe für gestresste Hefen: der Zellwand-Integritätsweg
Schweisthal, S., Sterk, C. C., & Heinisch, J. J. (2016) · BIOspektrum · doi:10.1007/s12268-016-0664-5
Not just the wall: the other ways to turn the yeast CWI pathway on
Jiménez‐Gutiérrez, E., Alegría‐Carrasco, E., Sellers-Moya, Á., Molina, M., & Martı́n, H. (2019) · International Microbiology · doi:10.1007/s10123-019-00092-2 · Cited by 59 · see citing works
Involvement of the Cell Wall–Integrity Pathway in Signal Recognition, Cell-Wall Biosynthesis, and Virulence in Magnaporthe oryzae
Lu, K., Chen, R., Yang, Y., Xu, H., Jiang, J., & Li, L. (2023) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-11-22-0231-cr · Cited by 42 · see citing works

Authors: Fuchs, B. B., & Mylonakis, E.
Affiliations: Harvard University (US)
ORCID: Fuchs, Beth Burgwyn
Mylonakis, Eleftherios
Venue: Eukaryotic Cell
Publisher: American Society for Microbiology
Published: 2009-11
Volume: 8
Issue: 11
Pages: 1616-1625
ISSN: 1535-9778 (ISSN-L)
1535-9786
DOI: 10.1128/ec.00193-09
PMC: PMC2772411
OpenAlex: W2136493024
Cited by: 266
References: 87
Citations by year: 2026: 17 · 2025: 14 · 2024: 12 · 2023: 9 · 2022: 21 · 2021: 17 · 2020: 22 · 2019: 12 · 2018: 22 · 2017: 16 · 2016: 17 · 2015: 20 · 2014: 17 · 2013: 12 · 2012: 14
FWCI: 0.97
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Eukaryotic Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R21AI079569, R01AI075286)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: stress response, MAPK signaling, pathway crosstalk, TOR signaling, calcineurin signaling, high-osmolarity glycerol pathway, cAMP/protein kinase A pathway, transcription factors, actin organization, cell wall biosynthesis, Saccharomyces cerevisiae, pH stress, osmotic stress, oxidative stress, nutrient deprivation
MeSH terms: Cell Wall, Fungal Proteins, Fungi, Saccharomyces cerevisiae, Stress, Physiological, Signal Transduction, Receptor Cross-Talk

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Our paths might cross: the role of the fungal cell wall integrity pathway in stress response and cross talk with other stress response pathways

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