Cited by 204Fungal and yeast genetics researchBacterial Genetics and BiotechnologyProtein Kinase Regulation and GTPase Signaling

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The Sequential Activation of the Yeast HOG and SLT2 Pathways Is Required for Cell Survival to Cell Wall Stress

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Bermejo, Clara, Rodríguez, Estefanía, García, Raúl, Rodríguez-Peña, Jose M., Rodríguez de la Concepción, María L., Rivas, Carmen, Arias, Patricia, Nombela, César, Posas, Francesc, Arroyo, Javier·2008·Molecular Biology of the Cell

DOI 10.1091/mbc.e07-08-0742PMC PMC2262984

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Abstract

Yeast mitogen-activated protein kinase (MAPK) signaling pathways transduce external stimuli into cellular responses very precisely. The MAPKs Slt2/Mpk1 and Hog1 regulate transcriptional responses of adaptation to cell wall and osmotic stresses, respectively. Unexpectedly, we observe that the activation of a cell wall integrity (CWI) response to the cell wall damage caused by zymolyase (β-1,3 glucanase) requires both the HOG and SLT2 pathways. Zymolyase activates both MAPKs and Slt2 activation depends on the Sho1 branch of the HOG pathway under these conditions. Moreover, adaptation to zymolyase requires essential components of the CWI pathway, namely the redundant MAPKKs Mkk1/Mkk2, the MAPKKK Bck1, and Pkc1, but it does not require upstream elements, including the sensors and the guanine nucleotide exchange factors of this pathway. In addition, the transcriptional activation of genes involved in adaptation to cell wall stress, like CRH1, depends on the transcriptional factor Rlm1 regulated by Slt2, but not on the transcription factors regulated by Hog1. Consistent with these findings, both MAPK pathways are essential for cell survival under these circumstances because mutant strains deficient in different components of both pathways are hypersensitive to zymolyase. Thus, a sequential activation of two MAPK pathways is required for cellular adaptation to cell wall damage.

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Methods in yeast genetics
Sherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,430
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Methods in yeast genetics : a Cold Spring Harbor Laboratory course manual
Amberg, D. C., Burke, D. J., & Strathern, J. N. (2005) · Cited by 1,803
Osmotic Stress Signaling and Osmoadaptation in Yeasts
Hohmann, S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.300-372.2002 · Cited by 1,773
Cell Wall Integrity Signaling in Saccharomyces cerevisiae
Levin, D. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.262-291.2005 · Cited by 1,136
A two-component system that regulates an osmosensing MAP kinase cascade in yeast
Maeda, T., Wurgler‐Murphy, S. M., & Saito, H. (1994) · Nature · doi:10.1038/369242a0 · Cited by 1,072
Cell Wall Assembly in Saccharomyces cerevisiae
Lesage, G., & Bussey, H. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00038-05 · Cited by 849
Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor
Maeda, T., Takekawa, M., & Saito, H. (1995) · Science · doi:10.1126/science.7624781 · Cited by 647
Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae.
Guarente, L., & Ptashne, M. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.4.2199 · Cited by 528
MAP kinase pathways
Qi, M., & Elion, E. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02470 · Cited by 524
Genome‐wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway
Jung, U. S., & Levin, D. E. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01667.x · Cited by 422
Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin β homologs NMD5 and XPO1
Ferrigno, P. K., Posas, F., Koepp, D. M., Saito, H., & Silver, P. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5606 · Cited by 417
Self-citation
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Roncero, C., & Durán, A. (1985) · Journal of Bacteriology · doi:10.1128/jb.163.3.1180-1185.1985 · Cited by 379
A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae
Verna, J., Lodder, A., Lee, K., Vagts, A. J., & Ballester, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13804 · Cited by 366
Regulatory Mechanisms for Modulation of Signaling through the Cell Integrity Slt2-mediated Pathway in Saccharomyces cerevisiae
Martı́n, H., Rodrı́guez-Pachón, J. M., Ruiz, C., Nombela, C., & Molina, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1511 · Cited by 343
Self-citation
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García, R., Bermejo, C., Grau, C., Pérez, R., Rodríguez-Peña, J. M., Francois, J., Nombela, C., & Arroyo, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312954200 · Cited by 338
Self-citation
Saccharomyces cerevisiae mannoproteins form an external cell wall layer that determines wall porosity
Zlotnik, H., Fernandez, M. P., Bowers, B., & Cabib, E. (1984) · Journal of Bacteriology · doi:10.1128/jb.159.3.1018-1026.1984 · Cited by 326
Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two‐component response regulator
Posas, F., & Saito, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1385 · Cited by 295
Self-citation
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Rep, M., Reiser, V., Gärtner, U., Thevelein, J. M., Hohmann, S., Ammerer, G., & Ruis, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5474 · Cited by 283
Cell wall perturbation in yeast results in dual phosphorylation of the Slt2/Mpk1 MAP kinase and in an Slt2-mediated increase in FKS2–lacZ expression, glucanase resistance and thermotolerance
de Nobel, H., Ruiz, C., Martı́n, H., Morris, W. L., Brul, S., Molina, M., & Klis, F. M. (2000) · Microbiology · doi:10.1099/00221287-146-9-2121 · Cited by 269
Saccharomyces cerevisiae Mid2p Is a Potential Cell Wall Stress Sensor and Upstream Activator of the PKC1-MPK1 Cell Integrity Pathway
Ketela, T., Green, R., & Bussey, H. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.11.3330-3340.1999 · Cited by 263
Unique and Redundant Roles for HOG MAPK Pathway Components as Revealed by Whole-Genome Expression Analysis
O’Rourke, S. M., & Herskowitz, I. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-07-0521 · Cited by 262
Genome-wide Analysis of the Response to Cell Wall Mutations in the Yeast Saccharomyces cerevisiae
Lagorce, A., Hauser, N. C., Labourdette, D., Rodriguez, C., Martin-Yken, H., Arroyo, J., Hoheisel, J. D., & François, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211604200 · Cited by 254
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Winkler, A., Arkind, C., Mattison, C. P., Burkholder, A. C., Knoche, K., & Ota, I. M. (2002) · Eukaryotic Cell · doi:10.1128/ec.1.2.163-173.2002 · Cited by 241
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Tatebayashi, K., Tanaka, K., Yang, H., Yamamoto, K., Matsushita, Y., Tomida, T., Imai, M., & Saito, H. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601796 · Cited by 238
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Reiser, V., Raitt, D. C., & Saito, H. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301099 · Cited by 234
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de Nadal, E., Alepuz, P. M., & Posas, F. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf158 · Cited by 233
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Agarwal, A. K., Rogers, P. D., Baerson, S. R., Jacob, M. R., Barker, K. S., Cleary, J. D., Walker, L. A., Nagle, D. G., & Clark, A. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306291200 · Cited by 204
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Thorsen, M. K., Di, Y., Tängemo, C., Morillas, M., Ahmadpour, D., der Does, C. V., Wagner, A., Johansson, E., Boman, J., Posas, F., et al. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-04-0315 · Cited by 195
Self-citation
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Rajavel, M., Philip, B., Buehrer, B. M., Errede, B., & Levin, D. E. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.3969 · Cited by 194
The yeast protein kinase C cell integrity pathway mediates tolerance to the antifungal drug caspofungin through activation of Slt2p mitogen-activated protein kinase signaling.
Reinoso-Martín, C., Schüller, C., Schuetzer-Muehlbauer, M., & Kuchler, K. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.6.1200-1210.2003 · Cited by 193
Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae , Rlm1, Which Has Transcriptional Activity Regulated by the Mpk1 (Slt2) Mitogen-Activated Protein Kinase Pathway
Watanabe, Y., Takaesu, G., Hagiwara, M., Irie, K., & Matsumoto, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2615 · Cited by 191
Targeting the MEF2-Like Transcription Factor Smp1 by the Stress-Activated Hog1 Mitogen-Activated Protein Kinase
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Self-citation
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Authors: Bermejo, C., Rodríguez, E., García, R., Rodríguez-Peña, J. M., Rodríguez de la Concepción, M. L., Rivas, C., Arias, P., Nombela, C., Posas, F., & Arroyo, J.
Affiliations: Universidad Complutense de Madrid (ES)
*Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain; and
Cell Signalling Unit, Department de Ciènces Experimentals I de la Salut, Universitat Pompeu Fabra (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), E-08003 Barcelona, Spain
Universitat Pompeu Fabra (ES)
ORCID: Bermejo, Clara
Rodríguez, Estefanía
García, Raúl
Rivas, Carmen
Nombela, César
Posas, Francesc
Arroyo, Javier
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 2008-03
Volume: 19
Issue: 3
Pages: 1113-1124
ISSN: 1059-1524 (ISSN-L)
1939-4586
DOI: 10.1091/mbc.e07-08-0742
PMC: PMC2262984
OpenAlex: W2103491947
Cited by: 204
References: 60
Citations by year: 2026: 11 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 7 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 16 · 2015: 18 · 2014: 17 · 2013: 7 · 2012: 15
FWCI: 7.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Biology of the Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Johns Hopkins University
Ministerio de Economía y Competitividad
Universitat de Lleida
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: HOG pathway, cell wall integrity, MAPK signaling, zymolyase, β-1,3-glucanase, cell wall stress, osmotic stress, Sho1, PKC1, Rlm1, Saccharomyces cerevisiae, stress adaptation, cell survival
MeSH terms: Adaptation, Physiological, Cell Wall, Enzyme Activation, Hydrolases, Mutation, Phosphorylation, Saccharomyces cerevisiae, Transcriptional Activation, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Saccharomyces cerevisiae Proteins, Microbial Viability

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The Sequential Activation of the Yeast HOG and SLT2 Pathways Is Required for Cell Survival to Cell Wall Stress

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