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Cited by 240Cellular transport and secretionExtracellular vesicles in diseaseFungal and yeast genetics research

The Exocyst at a Glance

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Wu, Bin, Guo, Wei·2015·Journal of Cell Science
DOI 10.1242/jcs.156398PMC PMC4541039
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Abstract

The exocyst is an octameric protein complex that is implicated in the tethering of secretory vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal control of exocytosis through the exocyst has a crucial role in a number of physiological processes, such as morphogenesis, cell cycle progression, primary ciliogenesis, cell migration and tumor invasion. In this Cell Science at a Glance poster article, we summarize recent works on the molecular organization, function and regulation of the exocyst complex, as they provide rationales to the involvement of this complex in such a diverse array of cellular processes.

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  • RalA is a vesicle-bound small GTPase promoting exocytosis through interacting with the exocyst complex.

    “Reps1 and Ralbp1 form a binary complex that recognizes RalA, a vesicle-bound small guanosine triphosphatases (GTPase) promoting exocytosis through interacting with the exocyst complex.”

    From Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module (2023) · cites this paper as [7]

    The Introduction (page not provided) identifies RalA as a Ral GTPase that interacts with the exocyst subunits Sec5 and Exo84, and links RalA–Sec5 engagement to exocytic trafficking. The passages do not establish that RalA is vesicle-bound. The separate statement about Reps1 and Ralbp1 is not the part attributed to this source. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Wu, B., & Guo, W.
Affiliations
University of Pennsylvania (US)
Corresponding author
Guo, Wei
ORCID
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2015-01-01
Volume
128
Issue
16
Pages
2957-64
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
DOI
10.1242/jcs.156398
PMC
PMC4541039
OpenAlex
W2463928272
Cited by
240
References
1
Citations by year
2026: 8 · 2025: 13 · 2024: 17 · 2023: 20 · 2022: 22 · 2021: 29 · 2020: 34 · 2019: 30 · 2018: 29 · 2017: 27 · 2016: 11
FWCI
2.27
Type
journal article
Language
en
Open access
Locations
  • Journal of Cell Science (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (R01GM111128, R01GM085146, GM085146, GM111128)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
exocyst complex, exocytosis, plasma membrane, morphogenesis, cell cycle progression, primary ciliogenesis, cell migration, tumor invasion, protein complex regulation
MeSH terms
Animals, Cell Cycle, Cell Membrane, Exocytosis, Humans, Membrane Fusion, Morphogenesis, rab GTP-Binding Proteins, ral Guanine Nucleotide Exchange Factor, Vesicular Transport Proteins, Membrane Fusion Proteins

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