Translational control in synaptic plasticity and cognitive dysfunction

Buffington, Shelly A.; Huang, Wei; Costa-Mattioli, Mauro

doi:10.1146/annurev-neuro-071013-014100

Cited by 348Neuroscience and Neuropharmacology ResearchRNA and protein synthesis mechanismsGenetics and Neurodevelopmental Disorders

Translational control in synaptic plasticity and cognitive dysfunction

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Buffington, Shelly A., Huang, Wei, Costa-Mattioli, Mauro·2014·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-071013-014100PMC PMC4721605

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Abstract

Activity-dependent changes in the strength of synaptic connections are fundamental to the formation and maintenance of memory. The mechanisms underlying persistent changes in synaptic strength in the hippocampus, specifically long-term potentiation and depression, depend on new protein synthesis. Such changes are thought to be orchestrated by engaging the signaling pathways that regulate mRNA translation in neurons. In this review, we discuss the key regulatory pathways that govern translational control in response to synaptic activity and the mRNA populations that are specifically targeted by these pathways. The critical contribution of regulatory control over new protein synthesis to proper cognitive function is underscored by human disorders associated with either silencing or mutation of genes encoding proteins that directly regulate translation. In light of these clinical implications, we also consider the therapeutic potential of targeting dysregulated translational control to treat cognitive disorders of synaptic dysfunction.

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When NMDAR activity is reduced, as with ketamine or 2R,6R-HNK, eEF2K activity falls, eEF2 becomes dephosphorylated, and translational inhibition is rapidly lifted.
“When NMDAR activity is reduced, as with ketamine or (2R,6R)-hydroxynorketamine (2R,6R-HNK), eEF2K activity falls, eEF2 becomes dephosphorylated, and translational inhibition is rapidly lifted [141,143,145].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [143]
In “Translational Control Mechanisms” (page not provided), the review says eEF2K phosphorylates eEF2, NMDAR activation increases eEF2 phosphorylation, and phosphorylated eEF2 is thought to block general translation. It does not report that reduced NMDAR activity—specifically from ketamine or (2R,6R)-HNK—lowers eEF2K activity, dephosphorylates eEF2, or rapidly lifts translational inhibition. (LLM, conf=0.84)
Experimental — accuracy not yet measured
eEF2K acts as a molecular brake on protein synthesis.
“Translational control is a central driver of rapid synaptic plasticity, with eEF2K acting as a molecular brake on protein synthesis [141,142,143].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [143]
Neuronal protein synthesis is crucial for synaptic function and memory formation, and it is dysregulated in Alzheimer's.
“Neuronal protein synthesis has been well established as crucial for synaptic function and memory formation, and it is dysregulated in Alzheimer’s (43).”
From Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis (2023) · cites this paper as [43]
Learning and long-term memory formation are improved by enhanced histone acetylation, which could be improved by HDAC inhibitors.
“The synthesis of new proteins is necessary for long-term changes in synaptic plasticity and learning (132–134). In this context, learning and long-term memory formation are improved by enhanced histone acetylation (135), which could be improved by HDAC inhibitors (HDACi).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [134]
The Introduction and Translational Control Mechanisms sections discuss protein synthesis and other mechanisms affecting long-term memory, but do not address enhanced histone acetylation or HDAC inhibitors. Searches of our copy for those terms found no passage supporting the claim attributed to this source. (LLM, conf=0.74)
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mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works
Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250 · see citing works
Upstream and downstream of mTOR
Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works
LTP and LTD
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853 · see citing works
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Sonenberg, N., & Hinnebusch, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.01.042 · Cited by 3,304 · see citing works
The mechanism of eukaryotic translation initiation and principles of its regulation
Jackson, R. J., Hellen, C. U. T., & Pestova, T. V. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2838 · Cited by 2,759 · see citing works
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706 · see citing works
Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558 · see citing works
FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072 · see citing works
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · cited 1× · see citing works
“Proteins synthesized locally in dendrites could be captured by synapses that have been “tagged” by previous activity, in what is defined as the synaptic tagging hypothesis (Frey & Morris 1997, Martin et al. 1997, Redondo & Morris 2011).”
Background
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
Vattem, K. M., & Wek, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400541101 · Cited by 1,696 · see citing works
A unifying model for mTORC1-mediated regulation of mRNA translation
Thoreen, C. C., Chantranupong, L., Keys, H. R., Wang, T., Gray, N. S., & Sabatini, D. M. (2012) · Nature · doi:10.1038/nature11083 · Cited by 1,477 · see citing works
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472 · see citing works
Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,351 · see citing works
The translational landscape of mTOR signalling steers cancer initiation and metastasis
Hsieh, A. C., Liu, Y., Edlind, M. P., Ingolia, N. T., Janes, M. R., Sher, A., Shi, E. Y., Stumpf, C. R., Christensen, C., Bonham, M. J., et al. (2012) · Nature · doi:10.1038/nature10912 · Cited by 1,313 · see citing works
TRANSLATIONAL REGULATION OFGCN4AND THE GENERAL AMINO ACID CONTROL OF YEAST
Hinnebusch, A. G. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.031805.133833 · Cited by 1,258 · see citing works
Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders
O’Roak, B. J., Vives, L., Fu, W., Egertson, J. D., Stanaway, I. B., Phelps, I. G., Carvill, G., Kumar, A., Lee, C., Ankenman, K., et al. (2012) · Science · doi:10.1126/science.1227764 · Cited by 1,240 · see citing works
Synaptic plasticity, memory and the hippocampus: a neural network approach to causality
Neves, G., Cooke, S. F., & Bliss, T. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2303 · Cited by 1,207 · see citing works
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051 · see citing works
mRNA localization: Gene expression in the spatial dimension
Martin, K. C., & Ephrussi, A. (2009) · Cell · doi:10.1016/j.cell.2009.01.044 · Cited by 1,048 · see citing works
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015 · see citing works
A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity
Kang, H., & Schuman, E. (1996) · Science · doi:10.1126/science.273.5280.1402 · Cited by 1,010 · see citing works
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
Lu, P. D., Harding, H. P., & Ron, D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408003 · Cited by 1,006 · see citing works
The epidemiology of autism: a review
FOMBONNE, E. (1999) · Psychological Medicine · doi:10.1017/s0033291799008508 · Cited by 981 · see citing works
Pten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works
Translational control of long-lasting synaptic plasticity and memory
Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944 · see citing works
Self-citation
Application of a translational profiling approach for the comparative analysis of CNS cell types
Doyle, J. P., Dougherty, J. D., Heiman, M., Schmidt, E. F., Stevens, T. R., Ma, G., Bupp, S., Shrestha, P., Shah, R. D., Doughty, M. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.029 · Cited by 912 · see citing works
Dendritic Protein Synthesis, Synaptic Plasticity, and Memory
Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 894 · see citing works
Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
Ehninger, D., Han, S., Shilyansky, C., Zhou, Y., Li, W., Kwiatkowski, D. J., Ramesh, V., & Silva, A. J. (2008) · Nature Medicine · doi:10.1038/nm1788 · Cited by 879 · see citing works
Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities
Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works
Making memories last: the synaptic tagging and capture hypothesis
Redondo, R. L., & Morris, R. G. M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2963 · Cited by 792 · see citing works
Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage.
Martin, K. C., Casadio, A., Zhu, H.-X., Yaping, E., Rose, J. C., Chen, M. C., Bailey, C. H., & Kandel, E. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80484-5 · Cited by 752 · see citing works
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
Tang, S. J., Reis, G., Kang, H., Gingras, A.-C., Sonenberg, N., & Schuman, E. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012605299 · Cited by 734 · see citing works
Pharmacological brake-release of mRNA translation enhances cognitive memory
Sidrauski, C., Acosta‐Alvear, D., Khoutorsky, A., Vedantham, P., Hearn, B. R., Li, H., Gamache, K., Gallagher, C. M., Ang, K. K. H., Wilson, C. G. M., et al. (2013) · eLife · doi:10.7554/elife.00498 · Cited by 732 · see citing works
Protein synthesis at synaptic sites on dendrites.
Steward, O., & Schuman, E. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.299 · Cited by 731 · see citing works
The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging
Cajigas, I. J., Tushev, G., Will, T. J., tom Dieck, S., Fuerst, N., & Schuman, E. M. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.036 · Cited by 709 · see citing works
Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus
Steward, O., & Levy, W. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-03-00284.1982 · Cited by 676 · see citing works
Translational control in biology and medicine
Mathews, M. B., Sonenberg, N., & Hershey, J. W. B. (2007) · Cited by 661 · see citing works
The Restless Engram: Consolidations Never End
Dudai, Y. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150500 · Cited by 644 · see citing works
The dsRNA protein kinase PKR: Virus and cell control
García, M. A., Meurs, E. F., & Esteban, M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.03.001 · Cited by 644 · see citing works
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasisPreprint
Ruvinsky, I., Sharon, N., Lerer, T., Cohen, H., Stolovich-Rain, M., Nir, T., Dor, Y., Zisman, P., & Meyuhas, O. (2005) · Genes & Development · doi:10.1101/gad.351605 · Cited by 640 · see citing works
Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus
Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R. M., Izquierdo, I., & Medina, J. H. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.025 · Cited by 633 · see citing works
Miniature Neurotransmission Stabilizes Synaptic Function via Tonic Suppression of Local Dendritic Protein Synthesis
Sutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633 · see citing works
Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease
Lüscher, C., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.016 · Cited by 627 · see citing works
The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP
Napoli, I., Mercaldo, V., Boyl, P. P., Eleuteri, B., Zalfa, F., De Rubeis, S., Di Marino, D., Mohr, E., Massimi, M., Falconi, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.031 · Cited by 609 · see citing works
Self-citation
Mutations causing syndromic autism define an axis of synaptic pathophysiology
Auerbach, B. D., Osterweil, E. K., & Bear, M. F. (2011) · Nature · doi:10.1038/nature10658 · Cited by 592 · see citing works
Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
Ma, T., Trinh, M. A., Wexler, A. J., Bourbon, C., Gatti, E., Pierre, P., Cavener, D. R., & Klann, E. (2013) · Nature Neuroscience · doi:10.1038/nn.3486 · Cited by 571 · see citing works
Evidence that fragile X mental retardation protein is a negative regulator of translation
Laggerbauer, B. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.4.329 · Cited by 571 · see citing works
A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties
Si, K., Lindquist, S. L., & Kandel, E. R. (2003) · Cell · doi:10.1016/s0092-8674(03)01020-1 · Cited by 565 · see citing works
Dysregulation of mTOR signaling in fragile X syndrome
Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557 · see citing works
Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
Hou, L., & Klann, E. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0995-04.2004 · Cited by 527 · see citing works
Autism-related deficits via dysregulated eIF4E-dependent translational control
Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P., et al. (2013) · Nature · doi:10.1038/nature11628 · Cited by 522 · see citing works
Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
Park, S., Park, J. M., Kim, S., Kim, J.-A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.023 · Cited by 516 · see citing works
The Elongation, Termination, and Recycling Phases of Translation in EukaryotesPreprint
Dever, T. E., & Green, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013706 · Cited by 507 · see citing works
A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis
Casadio, A., Martin, K. C., Giustetto, M., Zhu, H., Chen, M., Bartsch, D., Bailey, C. H., & Kandel, E. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81653-0 · Cited by 503 · see citing works
eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory
Costa‐Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, A. C., Sossin, W. S., Kaufman, R. J., Pelletier, J., Rosenblum, K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.050 · Cited by 500 · see citing works
Self-citation
The translation of translational control by FMRP: therapeutic targets for FXS
Darnell, J. C., & Klann, E. (2013) · Nature Neuroscience · doi:10.1038/nn.3379 · Cited by 491 · see citing works
CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses
Wu, L., Wells, D., Tay, J., Mendis, D., Abbott, M.-A., Barnitt, A., Quinlan, E., Heynen, A., Fallon, J. R., & Richter, J. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80630-3 · Cited by 488 · cited 1× · see citing works
“PABP promotes the recruitment of the eIF4F complex to the 5′ end of the mRNA and promotes translation of CamKIIα and NR2A mRNAs (Huang et al. 2002, Udagawa et al. 2012, Wu et al. 1998).”
Background
Temporally graded requirement for protein synthesis following memory reactivation
Milekic, M. H., & Alberini, C. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00976-5 · Cited by 455 · see citing works
The fragile X mental retardation protein inhibits translation via interacting with mRNA
Li, Z. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.2276 · Cited by 448 · see citing works
A Neuronal Isoform of CPEB Regulates Local Protein Synthesis and Stabilizes Synapse-Specific Long-Term Facilitation in Aplysia
Si, K., Giustetto, M., Etkin, A., Hsu, R., Janisiewicz, A. M., Miniaci, M. C., Kim, J., Zhu, H., & Kandel, E. R. (2003) · Cell · doi:10.1016/s0092-8674(03)01021-3 · Cited by 432 · see citing works
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
O’Connor, T., Sadleir, K. R., Maus, E., Velliquette, R. A., Zhao, J., Cole, S. L., Eimer, W. A., Hitt, B. D., Bembinster, L. A., Lammich, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.047 · Cited by 422 · see citing works
Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at Synapses in a Mouse Model of Fragile X Syndrome
Muddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0937-07.2007 · Cited by 421 · see citing works
Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2
Costa-Mattioli, M., Gobert, D., Harding, H., Herdy, B., Azzi, M., Bruno, M., Bidinosti, M., Mamou, C. B., Marcinkiewicz, E., Yoshida, M., et al. (2005) · Nature · doi:10.1038/nature03897 · Cited by 421 · see citing works
Self-citation
TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny‐Germano, L., Batista, A. F., Sathler, L. B., Brito‐Moreira, J., Amaral, O. B., Silva, C. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.002 · Cited by 415 · see citing works
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
Tsukiyama–Kohara, K., Poulin, F., Kohara, M., DeMaria, C. T., Cheng, A., Wu, Z., Gingras, A., Katsume, A., Elchebly, M., Spiegelman, B. M., et al. (2001) · Nature Medicine · doi:10.1038/nm1001-1128 · Cited by 392 · see citing works
Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation
Si, K., Choi, Y., White‐Grindley, E., Majumdar, A., & Kandel, E. R. (2010) · Cell · doi:10.1016/j.cell.2010.01.008 · Cited by 385 · see citing works
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
Santini, E., Huynh, T. N., MacAskill, A. F., Carter, A. G., Pierre, P., Ruggero, D., Kaphzan, H., & Klann, E. (2012) · Nature · doi:10.1038/nature11782 · Cited by 376 · see citing works
The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)
Bhakar, A. L., Dölen, G., & Bear, M. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153138 · Cited by 370 · see citing works
mTOR complexes in neurodevelopmental and neuropsychiatric disorders
Costa-Mattioli, M., & Monteggia, L. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3546 · Cited by 367 · see citing works
Self-citation
The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP
Govindarajan, A., Israely, I., Huang, S.-Y., & Tonegawa, S. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.008 · Cited by 349 · see citing works
Making synaptic plasticity and memory last: mechanisms of translational regulationPreprint
Richter, J. D., & Klann, E. (2009) · Genes & Development · doi:10.1101/gad.1735809 · Cited by 345 · see citing works
Genomics, Intellectual Disability, and Autism
Mefford, H. C., Batshaw, M. L., & Hoffman, E. P. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1114194 · Cited by 329 · see citing works
Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis
Bateup, H. S., Johnson, C. A., Denefrio, C. L., Saulnier, J. L., Kornacker, K., & Sabatini, B. L. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.017 · Cited by 327 · see citing works
Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics
Bagni, C., Tassone, F., Neri, G., & Hagerman, R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63141 · Cited by 321 · see citing works
The Translation Repressor 4E-BP2 Is Critical for eIF4F Complex Formation, Synaptic Plasticity, and Memory in the Hippocampus
Banko, J., Poulin, F., Hou, L., Demaria, C., Sonenberg, N., & Klann, E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2423-05.2005 · Cited by 317 · see citing works
Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice
Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P., & Klann, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.022 · Cited by 316 · see citing works
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1
Cammalleri, M., Lütjens, R., Berton, F., King, A. R., Simpson, C., Francesconi, W., & Sanna, P. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2336098100 · Cited by 314 · see citing works
mTORC2 controls actin polymerization required for consolidation of long-term memory
Huang, W., Zhu, P. J., Zhang, S., Zhou, H., Stoica, L., Galiano, M., Krnjević, K., Roman, G., & Costa-Mattioli, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3351 · Cited by 307 · see citing works
Self-citation
CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation
De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.039 · Cited by 296 · see citing works
N‐methyl‐D‐aspartate receptor signaling results in Aurora kinase‐catalyzed CPEB phosphorylation and αCaMKII mRNA polyadenylation at synapses
Huang, Y.-S., Jung, M.-Y., Sarkissian, M., & Richter, J. (2002) · EMBO Journal · doi:10.1093/emboj/21.9.2139 · Cited by 290 · see citing works
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimerʼs disease
Chang, R. C. C., Wong, A. K. Y., Ng, H.-K., & Hugon, J. (2002) · NeuroReport · doi:10.1097/00001756-200212200-00011 · Cited by 289 · see citing works
mTOR signaling to translation.
Gingras, A., Raught, B., & Sonenberg, N. (2004) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-18930-2_11 · Cited by 287 · see citing works
Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events
Sutton, M. A., Wall, N. R., Aakalu, G., & Schuman, E. (2004) · Science · doi:10.1126/science.1096202 · Cited by 286 · see citing works
Altered Cortical Synaptic Morphology and Impaired Memory Consolidation in Forebrain- Specific Dominant-Negative PAK Transgenic Mice
Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280 · see citing works
Inducible Enhancement of Memory Storage and Synaptic Plasticity in Transgenic Mice Expressing an Inhibitor of ATF4 (CREB-2) and C/EBP Proteins
Chen, A. Y.-C., Muzzio, I. A., Malleret, G., Bartsch, D., Verbitsky, M., Pavlidis, P., Yonan, A. L., Vronskaya, S., Grody, M. B., Cepeda, I. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00501-4 · Cited by 276 · see citing works
Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory
Majumdar, A., Cesario, W. C., White‐Grindley, E., Jiang, H., Ren, F., Khan, M. R., Li, L., Choi, E. M.-L., Kannan, K. S., Guo, F., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.004 · Cited by 275 · see citing works
Postsynaptic Decoding of Neural Activity: eEF2 as a Biochemical Sensor Coupling Miniature Synaptic Transmission to Local Protein Synthesis
Sutton, M. A., Taylor, A. M., Ito, H. T., Pham, A., & Schuman, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.030 · Cited by 274 · see citing works
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells
Stefani, G., Fraser, C. E., Darnell, J. C., & Darnell, R. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2306-04.2004 · Cited by 274 · see citing works
Postadolescent Changes in Regional Cerebral Protein Synthesis: AnIn VivoStudy in theFmr1Null Mouse
Qin, M., Kang, J., Burlin, T. V., Jiang, C., & Smith, C. B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0093-05.2005 · Cited by 263 · see citing works
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486
Dolan, B. M., Duron, S. G., Campbell, D. A., Vollrath, B., Rao, B. S. S., Ko, H.-Y., Lin, G. G., Govindarajan, A., Choi, S.-Y., & Tonegawa, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219383110 · Cited by 260 · see citing works
Local Protein Synthesis Mediates a Rapid Increase in Dendritic Elongation Factor 1A after Induction of Late Long-Term Potentiation
Tsokas, P., Grace, E., Chan, P., Ma, T., Sealfon, S., Iyengar, R., Landau, E., & Blitzer, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0599-05.2005 · Cited by 259 · see citing works
eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchangePreprint
Pavitt, G. D., Ramaiah, K. V. A., Kimball, S. R., & Hinnebusch, A. G. (1998) · Genes & Development · doi:10.1101/gad.12.4.514 · Cited by 256 · see citing works
mRNA Localization in Neurons: A Multipurpose Mechanism?
Steward, O. (1997) · Neuron · doi:10.1016/s0896-6273(01)80041-6 · Cited by 252 · see citing works
The fragile X mental retardation protein is associated with ribosomes
Khandjian, E. W., Corbin, F., Woerly, S., & Rousseau, F. (1996) · Nature Genetics · doi:10.1038/ng0196-91 · Cited by 251 · see citing works
Cognitive deficits in Tsc1+/−mice in the absence of cerebral lesions and seizures
Goorden, S. M. I., van Woerden, G. M., van der Weerd, L., Cheadle, J. P., & Elgersma, Y. (2007) · Annals of Neurology · doi:10.1002/ana.21317 · Cited by 247 · see citing works
Targeting the endocannabinoid system in the treatment of fragile X syndrome
Busquets-Garcia, A., Gomis-González, M., Guegan, T., Agustín-Pavón, C., Pastor, A., Mato, S., Pérez-Samartín, A., Matute, C., de la Torre, R., Dierssen, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3127 · Cited by 241 · see citing works
Termination and post-termination events in eukaryotic translation
Jackson, R. J., Hellen, C. U. T., & Pestova, T. V. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-386497-0.00002-5 · Cited by 237 · see citing works
Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
Stoica, L., Zhu, P. J., Huang, W., Zhou, H., Kozma, S. C., & Costa-Mattioli, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014715108 · Cited by 232 · see citing works
Self-citation
CPEB3 and CPEB4 in neurons: analysis of RNA‐binding specificity and translational control of AMPA receptor GluR2 mRNA
Huang, Y., Kan, M.-C., Lin, C., & Richter, J. D. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601322 · Cited by 229 · see citing works
Identification of Process-Localized mRNAs from Cultured Rodent Hippocampal Neurons
Poon, M. M., Choi, S.-H., Jamieson, C. A. M., Geschwind, D. H., & Martin, K. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3432-06.2006 · Cited by 225 · see citing works
PTEN signaling in brain: neuropathology and tumorigenesis
Endersby, R., & Baker, S. J. (2008) · Oncogene · doi:10.1038/onc.2008.239 · Cited by 222 · see citing works
Rapamycin for treating Tuberous Sclerosis and Autism Spectrum Disorders
Ehninger, D., & Silva, A. J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.10.002 · Cited by 220 · see citing works
Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition
Zhu, P. J., Huang, W., Kalikulov, D., Yoo, J. W., Placzek, A. N., Stoica, L., Zhou, H., Bell, J. C., Friedlander, M. J., Krnjević, K., et al. (2011) · Cell · doi:10.1016/j.cell.2011.11.029 · Cited by 215 · see citing works
Self-citation
Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function
Bateup, H. S., Takasaki, K. T., Saulnier, J. L., Denefrio, C. L., & Sabatini, B. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1617-11.2011 · Cited by 204 · see citing works
Brain-derived Neurotrophic Factor Enhances Neuronal Translation by Activating Multiple Initiation Processes
Takei, N., Kawamura, M., Hara, K., Yonezawa, K., & Nawa, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103237200 · Cited by 202 · see citing works
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α
Prisco, G. V. D., Huang, W., Buffington, S. A., Hsu, C.-C., Bonnen, P. E., Placzek, A. N., Sidrauski, C., Krnjević, K., Kaufman, R. J., Walter, P., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3754 · Cited by 201 · see citing works
Self-citation
The Unstable Repeats—Three Evolving Faces of Neurological Disease
Nelson, D. L., Orr, H. T., & Warren, S. T. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.022 · Cited by 200 · see citing works
Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E., & Tassone, F. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00768.x · Cited by 198 · see citing works
Antiviral effect of the mammalian translation initiation factor 2α kinase GCN2 against RNA viruses
Berlanga, J. J., Ventoso, I., Harding, H. P., Deng, J., Ron, D., Sonenberg, N., Carrasco, L., & de Haro, C. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601073 · Cited by 196 · see citing works
Spatially restricting gene expression by local translation at synapses
Wang, D. O., Martin, K. C., & Zukin, R. S. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.005 · Cited by 187 · see citing works
Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory
Bolduc, F. V., Bell, K., Cox, H., Broadie, K. S., & Tully, T. (2008) · Nature Neuroscience · doi:10.1038/nn.2175 · Cited by 187 · see citing works
Involvement of double‐stranded RNA‐dependent protein kinase and phosphorylation of eukaryotic initiation factor‐2α in neuronal degeneration
Chang, R. C., Suen, K., Ma, C., Elyaman, W., Ng, H., & Hugon, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01237.x · Cited by 180 · see citing works
Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse
Barak, S., Liu, F., Hamida, S. B., Yowell, Q. V., Neasta, J., Kharazia, V., Janak, P. H., & Ron, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3439 · Cited by 172 · see citing works
Local Presynaptic Activity Gates Homeostatic Changes in Presynaptic Function Driven by Dendritic BDNF Synthesis
Jakawich, S. K., Nasser, H. B., Strong, M. J., McCartney, A. J., Perez, A. S., Rakesh, N., Carruthers, C. J. L., & Sutton, M. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.034 · Cited by 171 · see citing works
Mitogen-Activated Protein Kinase Upregulates the Dendritic Translation Machinery in Long-Term Potentiation by Controlling the Mammalian Target of Rapamycin Pathway
Tsokas, P., Ma, T., Iyengar, R., Landau, E. M., & Blitzer, R. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4548-06.2007 · Cited by 168 · see citing works
An RNA‐dependent protein kinase is involved in tunicamycin‐induced apoptosis and Alzheimer's disease
Onuki, R., Bando, Y., Suyama, E., Katayama, T., Kawasaki, H., Baba, T., Tohyama, M., & Taira, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600049 · Cited by 163 · see citing works
Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation
Blundell, J., Kouser, M., & Powell, C. M. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.12.004 · Cited by 162 · see citing works
Selective Modulation of Some Forms of Schaffer Collateral-CA1 Synaptic Plasticity in Mice With a Disruption of the CPEB-1 GenePreprint
Alarcón, J. M., Hodgman, R., Theis, M., Huang, Y., Kandel, E. R., & Richter, J. D. (2004) · Learning & Memory · doi:10.1101/lm.72704 · Cited by 160 · see citing works
Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein
Khaleghpour, K., Kahvejian, A., Crescenzo, G. D., Roy, G., Svitkin, Y. V., Imataka, H., O'Connor‐McCourt, M. D., & Sonenberg, N. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5200-5213.2001 · Cited by 159 · see citing works
Sustained CPEB-Dependent Local Protein Synthesis Is Required to Stabilize Synaptic Growth for Persistence of Long-Term Facilitation in Aplysia
Miniaci, M. C., Kim, J., Puthanveettil, S. V., Si, K., Zhu, H., Kandel, E. R., & Bailey, C. H. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.036 · Cited by 146 · see citing works
Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility
Trinh, M. A., Kaphzan, H., Wek, R. C., Pierre, P., Cavener, D. R., & Klann, E. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.04.010 · Cited by 146 · see citing works
Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by mTOR/4E-BP1 Signaling
Cao, R., Robinson, B., Xu, H., Gkogkas, C. G., Khoutorsky, A., Alain, T., Yanagiya, A., Nevarko, T., Liu, A. C., Amir, S., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.026 · Cited by 143 · see citing works
Bidirectional Control of mRNA Translation and Synaptic Plasticity by the Cytoplasmic Polyadenylation Complex
Udagawa, T., Swanger, S. A., Takeuchi, K., Jong Heon, K. I. M., Nalavadi, V., Shin, J., Lorenz, L. J., Zukin, R. S., Bassell, G. J., & Richter, J. D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.016 · Cited by 141 · see citing works
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Lømo, T. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010273 · Cited by 135 · see citing works
Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology
Udagawa, T., Farny, N. G., Jakovcevski, M., Kaphzan, H., Alarcón, J. M., Anilkumar, S., Ivshina, M. P., Hurt, J. A., Nagaoka, K., Nalavadi, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3353 · Cited by 134 · see citing works
eIF2α Phosphorylation-Dependent Translation in CA1 Pyramidal Cells Impairs Hippocampal Memory Consolidation without Affecting General Translation
Jiang, Z., Belforte, J. E., Lü, Y., Yabe, Y., Pickel, J. M., Smith, C. B., Je, H. S., Lu, B., & Nakazawa, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3971-09.2010 · Cited by 127 · see citing works
Analysis of Subcellularly Localized mRNAs Using in Situ Hybridization, mRNA Amplification, and Expression Profiling
Eberwine, J. H., Belt, B. A., Kacharmina, J. E., & Miyashiro, K. (2002) · Neurochemical Research · doi:10.1023/a:1020956805307 · Cited by 122 · see citing works
Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism
Takeuchi, K., Gertner, M. J., Zhou, J., Parada, L. F., Bennett, M. V. L., & Zukin, R. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222803110 · Cited by 119 · see citing works
Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer’s disease
Page, G., Rioux Bilan, A., Ingrand, S., Lafay-Chebassier, C., Pain, S., Perault Pochat, M. C., Bouras, C., Bayer, T., & Hugon, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.047 · Cited by 116 · see citing works
Alzheimer's disease-associated reduction of polysomal mRNA translation
Langstrom, N. S., Anderson, J. P., Lindroos, H., Winbland, B., & Wallace, W. (1989) · Molecular Brain Research · doi:10.1016/0169-328x(89)90060-0 · Cited by 114 · see citing works
Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation
Hoeffer, C. A., Cowansage, K. K., Arnold, E. C., Banko, J. L., Moerke, N. J., Rodriguez, R., Schmidt, E. K., Klosi, E., Chorev, M., Lloyd, R. E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013063108 · Cited by 114 · see citing works
mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice
Antion, M., Hou, L., Wong, H., Hoeffer, C. A., & Klann, E. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00201-08 · Cited by 113 · see citing works
The mRNA for Elongation Factor 1α Is Localized in Dendrites and Translated in Response to Treatments That Induce Long-Term Depression
Huang, F.-S., Chotiner, J. K., & Steward, O. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1779-05.2005 · Cited by 112 · see citing works
Characterization of the Role of Microtubule-Associated Protein 1B in Metabotropic Glutamate Receptor-Mediated Endocytosis of AMPA Receptors in Hippocampus
Davidkova, G., & Carroll, R. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3334-07.2007 · Cited by 112 · see citing works
Reduced extinction of hippocampal-dependent memories in CPEB knockout micePreprint
Berger-Sweeney, J. E., Zearfoss, N. R., & Richter, J. D. (2006) · Learning & Memory · doi:10.1101/lm.73706 · Cited by 112 · see citing works
The role of eEF2 pathway in learning and synaptic plasticity
Taha, E., Gildish, I., Gal-Ben-Ari, S., & Rosenblum, K. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.04.015 · Cited by 111 · see citing works
Behavioral alterations in mice lacking the translation repressor 4E-BP2
Banko, J. L., Merhav, M., Stern, E., Sonenberg, N., Rosenblum, K., & Klann, E. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.08.012 · Cited by 110 · see citing works
A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding
Karim, M. M., Svitkin, Y. V., Kahvejian, A., Crescenzo, G. D., Costa‐Mattioli, M., & Sonenberg, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603701103 · Cited by 102 · see citing works
Self-citation
Drosophila CPEB Orb2A Mediates Memory Independent of Its RNA-Binding Domain
Krüttner, S., Stepien, B., Noordermeer, J. N., Mommaas, M. A., Mechtler, K., Dickson, B. J., & Keleman, K. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.028 · Cited by 101 · see citing works
13 eIF2α Phosphorylation in Cellular Stress Responses and DiseasePreprint
Ron, D., & Harding, H. (2007) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969767.48.345 · Cited by 92 · see citing works
Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission
Bidinosti, M., Ran, I., Sánchez-Carbente, M. R., Martineau, Y., Gingras, A., Gkogkas, C. G., Raught, B., Bramham, C., Sossin, W., Costa-Mattioli, M., et al. (2010) · Molecules and Cells · doi:10.1016/j.molcel.2010.02.022 · Cited by 90 · see citing works
Self-citation
Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats
Wang, X., Luo, Y.-X., He, Y.-Y., Li, F.-Q., Shi, H.-S., Xue, L.-F., Xue, Y.-X., & Lu, L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1264-10.2010 · Cited by 88 · see citing works
TOR Is Required for the Retrograde Regulation of Synaptic Homeostasis at the Drosophila Neuromuscular Junction
Penney, J., Tsurudome, K., Liao, E. H., Elazzouzi, F., Livingstone, M., González, M., Sonenberg, N., & Haghighi, A. P. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.030 · Cited by 88 · see citing works
A molecular switch for translational control in taste memory consolidation
Belelovsky, K., Elkobi, A., Kaphzan, H., Nairn, A. C., & Rosenblum, K. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04428.x · Cited by 85 · see citing works
Blocking the eIF2α Kinase (PKR) Enhances Positive and Negative Forms of Cortex-Dependent Taste Memory
Stern, E., Adaikkan, C., David, O., Sonenberg, N., & Rosenblum, K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2322-12.2013 · Cited by 79 · see citing works
Making and breaking synapses through local mRNA regulation
Swanger, S. A., & Bassell, G. J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.04.002 · Cited by 72 · see citing works
Synaptic tagging and capture in the living rat
Shires, K. L., Silva, B. M. D., Hawthorne, J. P., Morris, R., & Martin, S. J. (2012) · Nature Communications · doi:10.1038/ncomms2250 · Cited by 72 · see citing works
Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.
Khoutorsky, A., Yanagiya, A., Gkogkas, C., Fabian, M., Prager-Khoutorsky, M., Cao, R., Gamache, K., Bouthiette, F., Parsyan, A., Sorge, R., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.025 · Cited by 70 · see citing works
Retrograde changes in presynaptic function driven by dendritic mTORC1
Henry, F. E., McCartney, A. J., Neely, R., Perez, A. S., Carruthers, C., Stuenkel, E., Inoki, K., & Sutton, M. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2149-12.2012 · Cited by 68 · see citing works
Targeted treatment trials for tuberous sclerosis and autism: no longer a dream
Şahin, M. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.04.008 · Cited by 66 · see citing works
Deletion of the eIF2α Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer’s Disease
Devi, L., & Ohno, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077335 · Cited by 66 · see citing works
An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation
Dyer, J. R., Michel, S. H., Lee, W., Castellucci, V. F., Wayne, N. L., & Sossin, W. S. (2003) · Nature Neuroscience · doi:10.1038/nn1018 · Cited by 63 · see citing works
Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K micePreprint
Gildish, I., Manor, D., David, O., Sharma, V. K., Williams, D., Agarwala, U., Wang, X., Kenney, J. W., Proud, C. G., & Rosenblum, K. (2012) · Learning & Memory · doi:10.1101/lm.023937.111 · Cited by 62 · see citing works
Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures
Couturier, J., Paccalin, M., Morel, M., Terro, F., Milin, S., Pontcharraud, R., Fauconneau, B., & Page, G. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-72 · Cited by 61 · see citing works
Selective Regulation of GluA Subunit Synthesis and AMPA Receptor-Mediated Synaptic Function and Plasticity by the Translation Repressor 4E-BP2 in Hippocampal Pyramidal Cells
Ran, I., Gkogkas, C. G., Vasuta, C., Tartas, M., Khoutorsky, A., Laplante, I., Parsyan, A. E., Nevarko, T., Sonenberg, N., & Lacaille, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3264-12.2013 · Cited by 49 · see citing works
PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
Morel, M., Couturier, J., Lafay‐Chebassier, C., Paccalin, M., & Page, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00849.x · Cited by 47 · cited 1× · see citing works
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript PKR-eIF2α signaling is also implicated in AD (Morel et al. 2009).”
Background
Interaction of Double-stranded RNA-dependent Protein Kinase (PKR) with the Death Receptor Signaling Pathway in Amyloid β (Aβ)-treated Cells and in APPSLPS1 Knock-in Mice
Couturier, J., Morel, M., Pontcharraud, R., Gontier, V., Fauconneau, B., Paccalin, M., & Page, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041954 · Cited by 44 · see citing works
Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation
Hoeffer, C. A., Santini, E., Ma, T., Arnold, E. C., Whelan, A., Wong, H., Pierre, P., Pelletier, J., & Klann, E. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00342.2012 · Cited by 37 · see citing works
Compartment-specific, differential regulation of eukaryotic elongation factor 2 and its kinase within Aplysia sensory neurons
Weatherill, D. B., McCamphill, P. K., Pethoukov, E., Dunn, T. W., Fan, X., & Sossin, W. S. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07251.x · Cited by 30 · see citing works
Ribosomal Protein S6 Kinase Is a Critical Downstream Effector of the Target of Rapamycin Complex 1 for Long-term Facilitation in Aplysia
Weatherill, D. B., Dyer, J., & Sossin, W. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.071142 · Cited by 30 · see citing works

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The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works
The integrated stress response: From mechanism to disease
Costa-Mattioli, M., & Walter, P. (2020) · Science · doi:10.1126/science.aat5314 · Cited by 1,617 · see citing works
Self-citation
ER stress and the unfolded protein response in neurodegeneration
Hetz, C. A., & Saxena, S. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.99 · Cited by 1,006 · see citing works
Advancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827 · see citing works
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Decoding Neural Representational Spaces Using Multivariate Pattern Analysis
Haxby, J. V., Connolly, A. C., & Guntupalli, J. S. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170325 · Cited by 717 · see citing works
Is Alzheimer’s disease a type 3 diabetes? A critical appraisal
Kandimalla, R., Thirumala, V., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.018 · Cited by 621 · see citing works
Dynamic Axonal Translation in Developing and Mature Visual Circuits
Shigeoka, T., Jung, H., Jung, J., Turner-Bridger, B., Ohk, J., Lin, J. Q., Amieux, P. S., & Holt, C. E. (2016) · Cell · doi:10.1016/j.cell.2016.05.029 · Cited by 458 · see citing works
Ribosome Footprint Profiling of Translation throughout the Genome
Ingolia, N. T. (2016) · Cell · doi:10.1016/j.cell.2016.02.066 · Cited by 404 · see citing works
The Neurobiology of Language Beyond Single Words
Peter Hagoort, A., & Indefrey, P. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-013847 · Cited by 403 · see citing works
Soluble amyloid-Î² oligomers as synaptotoxins leading to cognitive impairment in Alzheimerâ€™s disease
Ferreira, S. T., Lourenco, M. V., Oliveira, M. M., & De Felice, F. G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00191 · Cited by 373 · see citing works
Biological roles of adenine methylation in RNA
Boulias, K., & Greer, E. L. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00534-0 · Cited by 353 · see citing works
The m6A epitranscriptome: transcriptome plasticity in brain development and function
Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0244-z · Cited by 330 · see citing works
Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury
Chou, A., Krukowski, K., Jopson, T. D., Zhu, P., Costa‐Mattioli, M., Walter, P., & Rosi, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707661114 · Cited by 253 · see citing works
Self-citation
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
Jiang, C.-C., Lin, L., Long, S., Ke, X., Fukunaga, K., Lu, Y., & Han, F. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01081-0 · Cited by 272 · see citing works
Translation deregulation in human disease
Tahmasebi, S., Khoutorsky, A., Mathews, M. B., & Sonenberg, N. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0034-x · Cited by 255 · see citing works
Modeling fragile X syndrome in the Fmr1 knockout mouse
Kazdoba, T. M., Leach, P. T., Silverman, J. L., & Crawley, J. N. (2014) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2014.01024 · Cited by 241 · see citing works
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 230 · see citing works
Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration
Baudry, M., & Bi, X. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.01.007 · Cited by 223 · see citing works
The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease
Tran, S. M.-S., & Mohajeri, M. H. (2021) · Nutrients · doi:10.3390/nu13030732 · Cited by 207 · see citing works
Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
Spinelli, M., Fusco, S., Mainardi, M., Scala, F., Natale, F., Lapenta, R., Mattera, A., Rinaudo, M., Puma, D. D. L., Ripoli, C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02221-9 · Cited by 208 · see citing works
Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization
Nakahata, Y., & Yasuda, R. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00029 · Cited by 209 · see citing works
Regulation of mRNA Translation in Neurons—A Matter of Life and Death
Kapur, M., Monaghan, C. E., & Ackerman, S. L. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.057 · Cited by 200 · see citing works
Presynaptic protein synthesis is required for long-term plasticity of GABA release
Younts, T. J., Monday, H. R., Dudok, B., Klein, M. E., Jordan, B., Katona, I., & Castillo, P. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.040 · Cited by 180 · see citing works
Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons
Descalzi, G., Gao, V., Steinman, M. Q., Suzuki, A., & Alberini, C. M. (2019) · Communications Biology · doi:10.1038/s42003-019-0495-2 · Cited by 188 · see citing works
De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability
Küry, S., van Woerden, G. M., Besnard, T., Proietti Onori, M., Latypova, X., Towne, M. C., Cho, M. T., Prescott, T. E., Ploeg, M. A., Sanders, S., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.10.003 · Cited by 185 · see citing works
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism
Huber, K. M., Klann, E., Costa-Mattioli, M., & Zukin, R. S. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2656-15.2015 · Cited by 167 · see citing works
Self-citation
Molecular mechanisms underlying alcohol-drinking behaviours
Ron, D., & Barak, S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.85 · Cited by 165 · see citing works
Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease
Mercado, G., Castillo, V., Soto, P., López, N., Axten, J. M., Sardi, S. P., Hoozemans, J. J. M., & Hetz, C. A. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.004 · Cited by 176 · see citing works
Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome
Zhu, P., Khatiwada, S., Cui, Y., Reineke, L. C., Dooling, S. W., Kim, J., Li, W., Walter, P., & Costa‐Mattioli, M. (2019) · Science · doi:10.1126/science.aaw5185 · Cited by 169 · see citing works
Self-citation
The unfolded protein response in neurodegenerative disorders – therapeutic modulation of the PERK pathway
Hughes, D., & Mallucci, G. R. (2018) · FEBS Journal · doi:10.1111/febs.14422 · Cited by 171 · see citing works
Molecular mechanisms of neuroplasticity: An expanding universe
Gulyaeva, N. V. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917030014 · Cited by 163 · see citing works
Exercise training improves motor skill learning via selective activation of mTOR
Chen, K., Zheng, Y., Wei, J., Ouyang, H., Huang, X., Zhang, F., Lai, C. S. W., Ren, C., So, K., & Zhang, L. (2019) · Science Advances · doi:10.1126/sciadv.aaw1888 · Cited by 163 · see citing works
Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes.
Woo, E., Sansing, L. H., Arnsten, A. F. T., & Datta, D. (2021) · Chronic Stress · doi:10.1177/24705470211029254 · Cited by 159 · see citing works
Region-specific RNA m 6 A methylation represents a new layer of control in the gene regulatory network in the mouse brain
Chang, M., Lv, H., Zhang, W., Ma, C., He, X., Zhao, S., Zhang, Z.-W., Zeng, Y., Song, S., Niu, Y., et al. (2017) · Open Biology · doi:10.1098/rsob.170166 · Cited by 160 · see citing works
Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis
Tudor, J. C., Davis, E. J., Peixoto, L., Wimmer, M. E., van Tilborg, E., Park, A. J., Poplawski, S. G., Chung, C. W., Havekes, R., Huang, J., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aad4949 · Cited by 158 · see citing works
Genome-wide identification and differential analysis of translational initiation
Zhang, P., He, D., Xu, Y., Hou, J., Pan, B.-F., Wang, Y., Liu, T., Davis, C. M., Ehli, E. A., Tan, L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01981-8 · Cited by 154 · see citing works
Measuring Consciousness in Severely Damaged Brains
Gosseries, O., Di, H., Laureys, S., & Boly, M. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170339 · Cited by 153 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
A Mitocentric View of Parkinson's Disease
Haelterman, N. A. T., Yoon, W. H., Sandoval, H., Jaiswal, M., Shulman, J. M., & Bellen, H. J. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014317 · Cited by 138 · see citing works
Polyphenols and neuroprotection: therapeutic implications for cognitive decline
Caruso, G., Torrisi, S. A., Mogavero, M. P., Currenti, W., Castellano, S., Godos, J., Ferri, R., Galvano, F., Leggio, G. M., Grosso, G., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108013 · Cited by 140 · see citing works
Translational Control in the Brain in Health and Disease
Sossin, W. S., & Costa-Mattioli, M. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032912 · Cited by 138 · see citing works
Self-citation
ER Proteostasis Control of Neuronal Physiology and Synaptic Function
Martínez, G., Khatiwada, S., Costa-Mattioli, M., & Hetz, C. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.05.009 · Cited by 126 · see citing works
Self-citation
Retinal energy metabolism in health and glaucoma
Casson, R. J., Chidlow, G., Crowston, J. G., Williams, P. A., & Wood, J. P. M. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100881 · Cited by 129 · see citing works
The Role of RNA Binding Proteins for Local mRNA Translation: Implications in Neurological Disorders
Thelen, M. P., & Kye, M. J. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00161 · Cited by 125 · see citing works
Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease
Felice, F. G. D., & Lourenco, M. V. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00094 · Cited by 120 · see citing works
Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency
Chen, C.-J., Sgritta, M., Mays, J., Zhou, H., Lucero, R., Park, J., Wang, I.-C., Park, J. H., Kaipparettu, B. A., Stoica, L., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0608-y · Cited by 121 · see citing works
Self-citation
Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice
Beckelman, B. C., Yang, W., Kasica, N. P., Zimmermann, H. R., Zhou, X., Keene, C. D., Ryazanov, A. G., & Ma, T. (2019) · Journal of Clinical Investigation · doi:10.1172/jci122954 · Cited by 112 · see citing works
RNA-binding proteins balance brain function in health and disease
Schieweck, R., Ninkovic, J., & Kiebler, M. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00047.2019 · Cited by 104 · see citing works
De-centralizing the Central Dogma: mRNA translation in space and time
Bourke, A. M., Schwarz, A., & Schuman, E. M. (2023) · Molecular Cell · doi:10.1016/j.molcel.2022.12.030 · Cited by 106 · see citing works
Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP
Majumder, P., Chu, J.-F., Chatterjee, B., Swamy, K. B. S., & Shen, C.-K. J. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1603-8 · Cited by 100 · see citing works
Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease
Ahmad, F., Singh, K., Das, D., Gowaikar, R., Shaw, E., Ramachandran, A., Rupanagudi, K. V., Kommaddi, R., Bennett, D., & Ravindranath, V. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6860 · Cited by 80 · see citing works
TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-Operation with FMRP and Staufen1: A Mechanistic View
Chu, J.-F., Majumder, P., Chatterjee, B., Huang, S., & Shen, C.-K. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2019.10.061 · Cited by 97 · see citing works
Reduced protein synthesis in schizophrenia patient-derived olfactory cells
English, J. A., Fan, Y., Föcking, M., Lopez, L. M., Hryniewiecka, M., Wynne, K. J., Dicker, P., Matigian, N., Cagney, G., Mackay‐Sim, A., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.119 · Cited by 96 · see citing works
Regulation of translation initiation factor eIF2B at the hub of the integrated stress response
Pavitt, G. D. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1491 · Cited by 92 · see citing works
Differential regulation of local mRNA dynamics and translation following long-term potentiation and depression
Donlin-Asp, P., Polisseni, C., Klimek, R., Heckel, A., & Schuman, E. M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017578118 · Cited by 92 · see citing works
The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons
Beckley, J. T., Laguesse, S., Phamluong, K., Morisot, N., Wegner, S. A., & Dorit Ron, A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2254-15.2016 · Cited by 89 · see citing works
Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α
Kabir, Z. D., Che, A., Fischer, D. K., Rice, R. C., Rizzo, B. K., Byrne, M., Glass, M. J., García, N. V. D. M., & Rajadhyaksha, A. M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.124 · Cited by 86 · see citing works
Single-molecule insights into mRNA dynamics in neurons
Buxbaum, A. R., Yoon, Y. J., Singer, R. H., & Park, H. Y. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.05.005 · Cited by 86 · see citing works
Metabolic Dysfunction in Alzheimer’s Disease: From Basic Neurobiology to Clinical Approaches
Clarke, J. R., Ribeiro, F. C., Frozza, R. L., Felice, F. G. D., & Lourenco, M. V. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179911 · Cited by 88 · see citing works
Macromolecular transport in synapse to nucleus communication
Panayotis, N., Karpova, A., Kreutz, M. R., & Fainzilber, M. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.12.001 · Cited by 81 · see citing works
Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition
Lang, D. G., Schott, B. H., van Ham, M., Morton, L., Kulikovskaja, L., Herrera‐Molina, R., Pielot, R., Klawonn, F., Montag, D., Jänsch, L., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1242-1 · Cited by 76 · see citing works
Small Molecules to Improve ER Proteostasis in Disease
Gonzalez‐Teuber, V., Albert‐Gascó, H., Auyeung, V. C., Papa, F. R., Mallucci, G. R., & Hetz, C. A. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.07.003 · Cited by 77 · see citing works
Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2
daSilva, L. L. P., Wall, M. J., de Almeida, L. P., Wauters, S. C., Januário, Y. C., Müller, J., & Corrêa, S. A. L. (2016) · eNeuro · doi:10.1523/eneuro.0144-15.2016 · Cited by 74 · see citing works
Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
Kapur, M., Ganguly, A., Nagy, G., Adamson, S. I., Chuang, J. H., Frankel, W. N., & Ackerman, S. L. (2020) · Neuron · doi:10.1016/j.neuron.2020.07.023 · Cited by 75 · see citing works
Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response
Johnson, J. L., Stoica, L., Liu, Y., Zhu, P., Bhattacharya, A., Buffington, S. A., Huq, R., Eissa, N. T., Larsson, O. S., Porse, B. T., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.027 · Cited by 77 · see citing works
Self-citation
Control of the eIF4E activity: structural insights and pharmacological implications
Romagnoli, A., D’Agostino, M., Ardiccioni, C., Maracci, C., Motta, S., Teana, A. L., & Marino, D. D. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03938-z · Cited by 70 · see citing works
eIF4E-Dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity
Uttam, S., Wong, C., Price, T. J., & Khoutorsky, A. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00470 · Cited by 75 · see citing works
Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes
Lourenco, M. V., Ferreira, S. T., & Felice, F. G. D. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.003 · Cited by 71 · see citing works
Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgene
Pitcher, M. R., Herrera, J. A., Buffington, S. A., Kochukov, M. Y., Merritt, J. K., Fisher, A., Schanen, N. C., Costa‐Mattioli, M., & Neul, J. L. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv030 · Cited by 70 · see citing works
Self-citation
Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions
Zakirova, Z., Fanutza, T., Bonet, J., Readhead, B., Zhang, W., Yi, Z., Beauvais, G., Zwaka, T. P., Ozelius, L. J., Blitzer, R. D., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007169 · Cited by 71 · see citing works
Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses
Berthoux, C., Barre, A., Bockaert, J., Marin, P., & Bécamel, C. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy064 · Cited by 68 · see citing works
A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density
Liu, S., Zhou, L., Yuan, H., Vieira, M., Sanz-Clemente, A., Badger, J. D., Lu, W., Traynelis, S. F., & Roche, K. W. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0827-16.2017 · Cited by 69 · see citing works
Abundance of ribosomal RNA gene copies in the genomes of schizophrenia patients
Chestkov, I. V., Jestkova, E. M., Ershova, E. S., Голимбет, В. Е., Лежейко, Т. В., NIu, K., Porokhovnik, L. N., Lyapunova, N. A., Izhevskaya, V. L., Kutsev, S. I., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.01.001 · Cited by 71 · see citing works
Drosophila as a Model for Infectious Diseases
Harnish, J. M., Link, N., & Yamamoto, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052724 · Cited by 69 · see citing works
The UPR and synaptic dysfunction in neurodegeneration
Freeman, O. J., & Mallucci, G. R. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.029 · Cited by 64 · see citing works
Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss
Tiwari, S. S., Mizuno, K., Ghosh, A., Aziz, W., Troakes, C., Daoud, J., Golash, V., Noble, W., Hortobágyi, T., & Giese, K. P. (2016) · Brain · doi:10.1093/brain/aww205 · Cited by 65 · see citing works
Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine
Huang, W., Placzek, A. N., Viana Di Prisco, G., Khatiwada, S., Sidrauski, C., Krnjević, K., Walter, P., Dani, J. A., & Costa-Mattioli, M. (2016) · eLife · doi:10.7554/elife.12052 · Cited by 64 · see citing works
Self-citation
Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1
Matias, I. C. P., Diniz, L. P., Buosi, A. S., Neves, G. A., Stipursky, J., & Gomes, F. C. A. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00184 · Cited by 64 · see citing works
Alcohol‐dependent molecular adaptations of the NMDA receptor system
Morisot, N., & Dorit Ron, A. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12363 · Cited by 61 · see citing works
The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress
Kim, S., Kim, D. K., Jeong, S., & Lee, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115894 · Cited by 67 · see citing works
eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures
Heise, C., Taha, E., Murru, L., Ponzoni, L., Cattaneo, A., Guarnieri, F. C., Montani, C., Mossa, A., Vezzoli, E., Ippolito, G., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw075 · Cited by 62 · see citing works
Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes
Schörnig, M., Ju, X.-C., Fast, L., Ebert, S., Weigert, A., Kanton, S., Schaffer, T., Kasri, N. N., Treutlein, B., Peter, B. M., et al. (2021) · eLife · doi:10.7554/elife.59323 · Cited by 62 · see citing works
Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
Fusco, S., Spinelli, M., Cocco, S., Ripoli, C., Mastrodonato, A., Natale, F., Rinaudo, M., Livrizzi, G., & Grassi, C. (2019) · Nature Communications · doi:10.1038/s41467-019-12793-3 · Cited by 61 · see citing works
Protein Translation and Psychiatric Disorders
Laguesse, S., & Dorit Ron, A. (2019) · The Neuroscientist · doi:10.1177/1073858419853236 · Cited by 59 · see citing works
Meet the players: local translation at the synapse
Moya, S. M. F., Bauer, K. E., & Kiebler, M. A. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00084 · Cited by 55 · see citing works
Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward
Laguesse, S., Morisot, N., Shin, J. H., Liu, F., Adrover, M. F., Sakhai, S. A., Lopez, M. F., Phamluong, K., Griffin, W. C., Becker, H. C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.037 · Cited by 58 · see citing works
The effects of proteasomal inhibition on synaptic proteostasis
Hakim, V., Cohen, L. D., Zuchman, R., Ziv, T., & Ziv, N. E. (2016) · The EMBO Journal · doi:10.15252/embj.201593594 · Cited by 52 · see citing works
Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders
Liu, Y., Chu, J. M. T., You, R., Zhang, Y., Chang, R. C., & Wong, G. T. C. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02483-1 · Cited by 52 · see citing works
The malleable brain: plasticity of neural circuits and behavior – a review from students to students
Schaefer, N., Rotermund, C., Blumrich, E., Lourenco, M. V., Joshi, P., Hegemann, R. U., Jamwal, S., Ali, N., Romero, E. M. G., Sharma, S., et al. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14107 · Cited by 50 · see citing works
Micro-RNAs in cognition and cognitive disorders: Potential for novel biomarkers and therapeutics
Woldemichael, B. T., & Mansuy, I. M. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.11.021 · Cited by 49 · see citing works
mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors
Liu, F., Laguesse, S., Legastelois, R., Morisot, N., Hamida, S. B., & Dorit Ron, A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.12 · Cited by 47 · see citing works
UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function
Notaras, M. J., Allen, M., Longo, F., Volk, N. L., Tóth, M., Jeon, N. L., Klann, E., & Colak, D. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0547-5 · Cited by 50 · see citing works
Life at Low Copy Number: How Dendrites Manage with So Few mRNAs
Kosik, K. S. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.002 · Cited by 44 · see citing works
The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis
Menon, S., Goldfarb, D., Ho, C. T., Cloer, E. W., Boyer, N. P., Hardie, C., Bock, A. J., Johnson, E. C., Anil, J., Major, M. B., et al. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-10-0622 · Cited by 46 · see citing works
Translational control of auditory imprinting and structural plasticity by eIF2α
Batista, G., Johnson, J. L., Dominguez, E. N., Costa‐Mattioli, M., & Peña, J. L. (2016) · eLife · doi:10.7554/elife.17197 · Cited by 46 · see citing works
Self-citation
Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function
Longo, F., Mancini, M., Ibraheem, P. L., Aryal, S., Mesini, C., Patel, J. C., Penhos, E., Rahman, N., Mamcarz, M., Santini, E., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01099-w · Cited by 47 · see citing works
Acupuncture attenuates cognitive deficits and increases pyramidal neuron number in hippocampal CA1 area of vascular dementia rats
Li, F., Yan, C.-Q., Lin, L.-T., Li, H., Zeng, X., Liu, Y., Du, S., Zhu, W. X., & Liu, C. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0656-x · Cited by 45 · see citing works
Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception
Mazziotti, R. M., Baroncelli, L., Ceglia, N., Chelini, G., Sala, G. D., Magnan, C., Napoli, D., Putignano, E., Silingardi, D., Tola, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15488 · Cited by 45 · see citing works
Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke
Wang, H., Gaur, U., Xiao, J., Xu, B., Xu, J., & Zheng, W. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.26230 · Cited by 46 · see citing works

Translational Control of Synaptic Plasticity and Memory
Khoutorsky, A., Gkogkas, C. G., & Sonenberg, N. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3991-2_14 · Cited by 1 · see citing works
Translational control of long-lasting synaptic plasticity and memory
Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944 · see citing works
Self-citation
Chapter 8 Translational Regulatory Mechanisms in Synaptic Plasticity and Memory Storage
Costa‐Mattioli, M., Sonenberg, N., & Richter, J. D. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)90008-4 · Cited by 43 · see citing works
Self-citation
Translational control of synaptic plasticity and learning and memoryPreprint
Klann, E., & Richter, J. D. (2007) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969767.48.485 · Cited by 21 · see citing works
Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs
Santini, E., & Klann, E. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00076 · Cited by 32 · see citing works

Authors: Buffington, S. A., Huang, W., & Costa-Mattioli, M.
Affiliations: Baylor College of Medicine (US)
Department of Neuroscience, Memory and Brain Research Center, Baylor College of Medicine, Houston, Texas 77030;, ,
ORCID: Buffington, Shelly A.
Huang, Wei
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2014-07-08
Volume: 37
Issue: 1
Pages: 17-38
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-071013-014100
PMC: PMC4721605
OpenAlex: W2120053143
Cited by: 348
References: 166
Citations by year: 2026: 17 · 2025: 23 · 2024: 21 · 2023: 20 · 2022: 24 · 2021: 36 · 2020: 36 · 2019: 30 · 2018: 43 · 2017: 33 · 2016: 33 · 2015: 21 · 2014: 11
FWCI: 3.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Defense
Searle Scholars Program
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke (R01NS076708)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: translational regulation, synaptic plasticity, long-term potentiation, long-term depression, hippocampus, mRNA translation, memory formation, cognitive impairment, synaptic dysfunction
MeSH terms: Animals, Cognition Disorders, Hippocampus, Humans, Models, Biological, Nerve Tissue Proteins, Neuronal Plasticity, Protein Biosynthesis, Signal Transduction

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