Is there a role for physical activity in preventing cognitive decline in people with mild cognitive impairment?
Abstract
Mild cognitive impairment (MCI) is a common clinical syndrome that identifies people at high risk of developing dementia. Although treatments for MCI are currently unavailable, preliminary evidence has identified potential neuro-protective effects of physical activity, which may lead to improved outcomes. However, there is uncertainty regarding the effectiveness, feasibility and acceptability of this treatment strategy. These uncertainties require further investigation before physical activity interventions can be recommended for routine care.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exercise has physiological effects on the brain, endocrine system, immune system and skeletal muscle.
“Exercise has physiological effects on the brain, endocrine system, immune system and skeletal muscle (42, 117-120).”
From Frailty in elderly people (2013) · cites this paper as [120]
Cites
(1985) · Europe PMC (PubMed Central) · Cited by 9,143 · see citing works
Correlates of adults??? participation in physical activity: review and update
TROST, S. G., OWEN, N., BAUMAN, A. E., SALLIS, J. F., & BROWN, W. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200212000-00020 · Cited by 3,040 · see citing works
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290 · see citing works
Risk of dementia in diabetes mellitus: a systematic review
Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70284-2 · Cited by 2,187 · see citing works
Leisure Activities and the Risk of Dementia in the Elderly
Verghese, J., Lipton, R. B., Katz, M. J., Hall, C. B., Derby, C. A., Kuslansky, G., Ambrose, A. F., Sliwinski, M., & Buschke, H. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022252 · Cited by 1,961 · see citing works
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.397 · Cited by 1,833 · see citing works
Mitchell, A. J., & Shiri‐Feshki, M. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01326.x · Cited by 1,659 · cited 2× · see citing works
“In people aged 70 years and older, the reported prevalence of MCI ranges from 14 to 18% and the progression rate to dementia is 5–15% per year [2]; considerably greater than the 1–6% per year for people without MCI [1].”
BackgroundLautenschlager, N. T., Cox, K. L., Flicker, L., Foster, J. K., van Bockxmeer, F. M., Xiao, J., Greenop, K. R., & Almeida, O. P. (2008) · JAMA · doi:10.1001/jama.300.9.1027 · Cited by 1,637 · see citing works
Mild Cognitive Impairment: Ten Years Later
Petersen, R. C., Roberts, R. O., Knopman, D. S., Boeve, B. F., Geda, Y. E., Ivnik, R. J., Smith, G. E., & Jack, C. R. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.266 · Cited by 1,447 · see citing works
Physical activity and risk of cognitive decline: a meta-analysis of prospective studies
Sofi, F., Valecchi, D., Bacci, D., Abbate, R., Gensini, G. F., Casini, A., & Macchi, C. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02281.x · Cited by 1,210 · see citing works
Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial
Baker, L. D., Frank, L. L., Foster-Schubert, K., Green, P. S., Wilkinson, C. W., McTiernan, A., Plymate, S. R., Fishel, M. A., Watson, G. S., Cholerton, B. A., et al. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.307 · Cited by 1,171 · see citing works
Aerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017 · see citing works
Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence
Hamer, M., & Chida, Y. (2009) · Psychological Medicine · doi:10.1017/s0033291708003681 · Cited by 988 · see citing works
The neuropathology of probable Alzheimer disease and mild cognitive impairment
Schneider, J. A., Arvanitakis, Z., Leurgans, S. E., & Bennett, D. A. (2009) · Annals of Neurology · doi:10.1002/ana.21706 · Cited by 935 · see citing works
Exercise and the brain: something to chew on
van Praag, H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.007 · Cited by 599 · see citing works
Exercise protects the cardiovascular system: effects beyond traditional risk factors
Joyner, M. J., & Green, D. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179432 · Cited by 520 · see citing works
Physical Exercise, Aging, and Mild Cognitive Impairment: A Population-Based Study
Geda, Y. E., Roberts, R. O., Knopman, D. S., Christianson, T. J. H., Pankratz, V. S., Ivnik, R. J., Boeve, B. F., Tangalos, E. G., Petersen, R. C., & Rocca, W. A. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.297 · Cited by 371 · see citing works
van Uffelen, J. G. Z., Chinapaw, M. J. M., van Mechelen, W., & Hopman-Rock, M. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2007.044735 · Cited by 279 · see citing works
Is physical activity a potential preventive factor for vascular dementia? A systematic review
Aarsland, D., Sardahaee, F. S., Anderssen, S., Ballard, C., & the Alzheimer's Society Systematic Review group (2010) · Aging & Mental Health · doi:10.1080/13607860903586136 · Cited by 195 · see citing works
Ennezat, P. V., Malendowicz, S. L., Testa, M., Colombo, P. C., Solal, A. C., Evans, T., & LeJemtel, T. H. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01321-3 · Cited by 147 · see citing works
Role of Aerobic Fitness and Aging on Cerebral White Matter Integrity
Marks, B. L., Madden, D. J., Bucur, B., Provenzale, J. M., WHITE, L. E., Cabeza, R. E. L., & Huettel, S. A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.022 · Cited by 145 · see citing works
Effects of exercise on brain function: role of free radicals
Radak, Z. O., Kumagai, S., Taylor, A. W., Naıto, H., & Goto, S. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-081 · Cited by 141 · see citing works
Effect of Physical Activity on Cognitive Function in Older Adults at Risk for Alzheimer Disease
Lautenschlager, N. T., Cox, K. L., Flicker, L. A., Foster, J. K., BOCKXMEER, F. M. V., Xiao, J., Greenop, K. R., & Almeida, O. P. (2011) · Cited by 98 · see citing works
Pharmacomimetics of Exercise: Novel Approaches for Hippocampally- Targeted Neuroprotective Agents
Stranahan, A. M., Zhou, Y., Martin, B., & Maudsley, S. R. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709789878292 · Cited by 83 · see citing works
Making Physical Activity Accessible to Older Adults With Memory Loss: A Feasibility Study
Logsdon, R. G., McCurry, S. M., Pike, K. C., & Teri, L. L. (2009) · The Gerontologist · doi:10.1093/geront/gnp082 · Cited by 52 · see citing works
Cardiovascular Dementia - A Different Perspective
Kumari, U., & Heese, K. (2010) · The Open Biochemistry Journal · doi:10.2174/1874091x01004010029 · Cited by 27 · see citing works
Uchida, S., Suzuki, A., Kagitani, F., & Hotta, H. (2006) · The Journal of Physiological Sciences · doi:10.2170/physiolsci.sc001706 · Cited by 13 · see citing works
Association Between Lobar-Type Hemorrhage and Amyloid Angiopathy
Hill, M. D., & Silver, F. L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.10.1705 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503 · see citing works
Self-citationFiatarone Singh, M. A., Gates, N., Saigal, N., Wilson, G. C., Meiklejohn, J., Brodaty, H., Wen, W., Singh, N., Baune, B. T., Suo, C., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.09.010 · Cited by 424 · see citing works
Gates, N., Fiatarone Singh, M. A., Sachdev, P. S., & Valenzuela, M. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.02.018 · Cited by 355 · see citing works
Ji, L., Zhang, H., Potter, G. G., Zang, Y.-F., Steffens, D. C., Guo, H., & Wang, L. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00102 · Cited by 43 · see citing works
Ellis, J. L., Altenburger, P., & Lu, Y. (2019) · Journal of Geriatric Physical Therapy · doi:10.1519/jpt.0000000000000143 · Cited by 10 · see citing works
- Authors
- Barber, S. E., Clegg, A. P., & Young, J. B.
- Affiliations
- Bradford Institute for Health Research (GB)
- Corresponding author
- Barber, S. E.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11-13
- Volume
- 41
- Issue
- 1
- Pages
- 5-8
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W2154908237
- Cited by
- 52
- References
- 28
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 13 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 5
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Age and Ageing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- physical activity, mild cognitive impairment, cognitive decline, dementia prevention, neuroprotection, exercise intervention, feasibility and acceptability
- MeSH terms
- Aged, Aged, 80 and over, Dementia, Female, Humans, Male, Motor Activity, Randomized Controlled Trials as Topic, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review