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Cited by 661Fatty Acid Research and HealthNutritional Studies and DietCardiovascular Health and Risk Factors

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women

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Hu, Frank B, Stampfer, Meir J, Manson, JoAnn E, Ascherio, Alberto, Colditz, Graham A, Speizer, Frank E, Hennekens, Charles H, Willett, Walter C·1999·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/70.6.1001
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Abstract

Background Metabolic studies suggest that saturated fatty acids differ in their effects on blood lipids.Objective The objective was to examine the associations between intakes of individual saturated fatty acids and their food sources in relation to the risk of coronary heart disease (CHD).Design This was a prospective cohort study of 80082 women in the Nurses' Health Study aged 34-59 y. Subjects had no known cardiovascular disease, cancer, hypercholesterolemia, or diabetes, and completed validated food-frequency questionnaires in 1980.Results During 14 y of follow-up, we documented 939 incident cases of major CHD events. In multivariate analyses in which age, smoking, and other covariates were controlled for, intakes of short- to medium-chain saturated fatty acids (4:0-10:0) were not significantly associated with the risk of CHD. In contrast, intakes of longer-chain saturated fatty acids (12:0-18:0) were each separately associated with a small increase in risk. The multivariate RR for a 1% energy increase from stearic acid was 1.19 (95% CI: 1.02, 1.37). The ratio of polyunsaturated to saturated fat was strongly and inversely associated with CHD risk (multivariate RR for a comparison of the highest with the lowest deciles: 0.58; 95% CI: 0.41, 0.83; P for trend < 0.0001). Conversely, higher ratios of red meat to poultry and fish consumption and of high-fat to low-fat dairy consumption were associated with significantly greater risk.Conclusion A distinction between stearic acid and other saturated fats does not appear to be important in dietary advice to reduce CHD risk, in part because of the high correlation between stearic acid and other saturated fatty acids in typical diets.

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  1. Zock, 1994, Impact of myristic acid versus palmitic acid on plasma lipids and lipoprotein levels in healthy women and men, Arterioscler Thromb, 60, 919

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Metadata

Authors
Hu, F. B., Stampfer, M. J., Manson, J. E., Ascherio, A., Colditz, G. A., Speizer, F. E., Hennekens, C. H., & Willett, W. C.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Hu, Frank B
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1999-12
Volume
70
Issue
6
Pages
1001-1008
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/70.6.1001
OpenAlex
W2150396523
Cited by
661
References
25
Citations by year
2026: 3 · 2025: 10 · 2024: 19 · 2023: 17 · 2022: 17 · 2021: 23 · 2020: 23 · 2019: 24 · 2018: 28 · 2017: 38 · 2016: 38 · 2015: 37 · 2014: 39 · 2013: 39 · 2012: 29
FWCI
9.79
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL24074, HL34594, R01HL034594)
  • National Cancer Institute (CA-40356)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
saturated fatty acids, coronary artery disease, women, stearic acid, long-chain saturated fatty acids, polyunsaturated to saturated fat ratio, dietary fat intake, food sources, red meat consumption, milk fat, Nurses' Health Study
MeSH terms
Adult, Coronary Disease, Dairy Products, Dietary Fats, Fatty Acids, Female, Follow-Up Studies, Humans, Meat, Middle Aged, Prospective Studies, Surveys and Questionnaires, Risk Factors, United States, Cohort Studies, Multivariate Analysis, Women's Health

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